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Keywords: lac repressor
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Articles

Exploitation of the Escherichia coli lac operon promoter for controlled recombinant protein production

Douglas F. Browning, Rita E. Godfrey, Kirsty L. Richards, Colin Robinson, Stephen J.W. Busby
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (2): 755–763.
https://doi.org/10.1042/BST20190059
Published: 10 April 2019
... 17 3 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bacterial transcription initiation Escherichia coli lac promoter lac repressor recombinant protein production tac promoter Most of the recombinant protein...
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Articles

Structural insights into the role of architectural proteins in DNA looping deduced from computer simulations

Wilma K. Olson, Michael A. Grosner, Luke Czapla, David Swigon
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (2): 559–564.
https://doi.org/10.1042/BST20120341
Published: 21 March 2013
... of various proteins. For example, the Escherichia coli Lac repressor protein binds DNA operators, separated by 92 or 401 bp, and suppresses the formation of gene products involved in the metabolism of lactose. The system also includes several highly abundant architectural proteins, such as the histone-like...
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