1-27 of 27
Keywords: leucine-rich repeat kinase 2 (LRRK2)
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles

The unconventional G-protein cycle of LRRK2 and Roco proteins

Available to Purchase
Susanne Terheyden, Laura M. Nederveen-Schippers, Arjan Kortholt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1611–1616.
https://doi.org/10.1042/BST20160224
Published: 02 December 2016
...Susanne Terheyden; Laura M. Nederveen-Schippers; Arjan Kortholt Mutations in the human leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of hereditary Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins, which are characterized by the presence of a Ras of complex...
View articletitled, The unconventional G-protein cycle of LRRK2 and Roco proteins
Open the PDF for The unconventional G-protein cycle of LRRK2 and Roco proteins in another window
Articles

Two-pore channels at the intersection of endolysosomal membrane traffic

Available to Purchase
Jonathan S. Marchant, Sandip Patel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 434–441.
https://doi.org/10.1042/BST20140303
Published: 01 June 2015
... to endolysosomal trafficking dysfunction. 1 Correspondence may be addressed to either author (email [email protected] or [email protected] ) . 18 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 Ca 2+ lysosomes leucine-rich repeat kinase 2 (LRRK2) NAADP...
View articletitled, Two-pore channels at the intersection of endolysosomal membrane traffic
Open the PDF for Two-pore channels at the intersection of endolysosomal membrane traffic in another window
Articles

Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease

Available to Purchase
Pilar Rivero-Ríos, Patricia Gómez-Suaga, Belén Fernández, Jesús Madero-Pérez, Andrew J. Schwab, Allison D. Ebert, Sabine Hilfiker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 390–395.
https://doi.org/10.1042/BST20140301
Published: 01 June 2015
...Pilar Rivero-Ríos; Patricia Gómez-Suaga; Belén Fernández; Jesús Madero-Pérez; Andrew J. Schwab; Allison D. Ebert; Sabine Hilfiker Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene comprise the most common cause of familial Parkinson's disease (PD), and variants increase the risk...
View articletitled, Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease
Open the PDF for Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease in another window
Articles

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

Available to Purchase
Joel E. Beevers, Tara M. Caffrey, Richard Wade-Martins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1503–1508.
https://doi.org/10.1042/BST20130194
Published: 20 November 2013
... Biochemical Society 2013 autophagy dopaminergic neuron induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) mitochondrion Parkinson’s disease (PD) Autophagy is the process by which cells degrade damaged proteins and organelles, and is further induced by starvation...
View articletitled, Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease
Open the PDF for Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease in another window
Articles

The synaptic function of LRRK2

Available to Purchase
Seongsoo Lee, Yuzuru Imai, Stephan Gehrke, Song Liu, Bingwei Lu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1047–1051.
https://doi.org/10.1042/BST20120113
Published: 19 September 2012
... be addressed (email [email protected] ). 27 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 Drosophila leucine-rich repeat kinase 2 (LRRK2) microtubule dynamics mitochondrial transport neuromuscular junction synaptic growth Despite decades...
View articletitled, The synaptic function of LRRK2
Open the PDF for The synaptic function of LRRK2 in another window
Articles

Cellular effects of LRRK2 mutations

Available to Purchase
Mark R. Cookson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1070–1073.
https://doi.org/10.1042/BST20120165
Published: 19 September 2012
... inclusion body leucine-rich repeat kinase 2 (LRRK2) neurite Parkinson's disease The identification of dominant mutations in LRRK2 (leucine-rich repeat kinase 2) by two groups in 2004 [ 1 , 2 ], together with the subsequent demonstration of a segregating variant in the same gene in the first...
View articletitled, Cellular effects of LRRK2 mutations
Open the PDF for Cellular effects of LRRK2 mutations in another window
Articles

MASL1: a neglected ROCO protein

Available to Purchase
Sybille Dihanich
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1090–1094.
https://doi.org/10.1042/BST20120127
Published: 19 September 2012
... ] or functions to which no link has yet been established. 1 email [email protected] 1 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 leucine-rich repeat kinase 2 (LRRK2) malignant fibrous histiocytoma amplified sequences with leucine-rich...
View articletitled, MASL1: a neglected ROCO protein
Open the PDF for MASL1: a neglected ROCO protein in another window
Articles

LRRK2 and vesicle trafficking

Available to Purchase
Giovanna Sanna, Maria Grazia Del Giudice, Claudia Crosio, Ciro Iaccarino
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1117–1122.
https://doi.org/10.1042/BST20120117
Published: 19 September 2012
... The Authors Journal compilation © 2012 Biochemical Society 2012 cytoskeleton endocytosis exocytosis leucine-rich repeat kinase 2 (LRRK2) More unequivocal are the experimental results on the LRKK2 intracellular localization. Different experimental approaches have demonstrated that LRRK2...
View articletitled, LRRK2 and vesicle trafficking
Open the PDF for LRRK2 and vesicle trafficking in another window
Articles

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling

Available to Purchase
Patricia Gómez-Suaga, Grant C. Churchill, Sandip Patel, Sabine Hilfiker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1140–1146.
https://doi.org/10.1042/BST20120138
Published: 19 September 2012
... of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease Nat. Rev. Neurosci. 2010 11 791 797 8 Greggio E. Cookson M.R. Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions ASN NEURO 2009 1 art:e00002.doi:10.1042/AN20090007 9 Berwick D.C...
View articletitled, A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling
Open the PDF for A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling in another window
Articles

Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins

Available to Purchase
Shani Bialik, Adi Kimchi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1052–1057.
https://doi.org/10.1042/BST20120155
Published: 19 September 2012
... kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment J. Neurochem. 2009 111 703 715 33 Drolet R.E. Sanders J.M. Kern J.T. Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions J...
View articletitled, Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins
Open the PDF for Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins in another window
Articles

Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?

Available to Purchase
Laura Civiero, Luigi Bubacco
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1095–1101.
https://doi.org/10.1042/BST20120123
Published: 19 September 2012
.... Jain S. Ding J. Syed A. The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation J. Biol. Chem. 2008 283 16906 16914 24 Nichols R.J. Dzamko N. Morrice N.A. Campbell D.G. Deak M...
View articletitled, Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?
Open the PDF for Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions? in another window
Articles

LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease

Available to Purchase
Yulan Xiong, Valina L. Dawson, Ted M. Dawson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1074–1079.
https://doi.org/10.1042/BST20120093
Published: 19 September 2012
... be addressed (email [email protected] ). 28 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) GTPase kinase leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease ArfGAP1 ADP...
View articletitled, LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease
Open the PDF for LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease in another window
Articles

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

Available to Purchase
Daniel C. Berwick, Kirsten Harvey
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1123–1128.
https://doi.org/10.1042/BST20120122
Published: 19 September 2012
... genetics of Parkinson's disease leucine-rich repeat kinase 2 (LRRK2) neurodegeneration Parkinson's disease treatment Wnt signalling PD (Parkinson's disease) is the second most prevalent neurodegenerative disease worldwide. Individuals with PD present with typical motor symptoms...
View articletitled, The importance of Wnt signalling for neurodegeneration in Parkinson's disease
Open the PDF for The importance of Wnt signalling for neurodegeneration in Parkinson's disease in another window
Articles

LRRK2 and autophagy: a common pathway for disease

Available to Purchase
Claudia Manzoni
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1147–1151.
https://doi.org/10.1042/BST20120126
Published: 19 September 2012
.... Koeman J. Swiatek P.J. Giordano T.J. West A.B. Resau J.H. Teh B.T. MacKeigan J.P. Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas Proc. Natl. Acad. Sci. U.S.A. 2011 108 1439...
View articletitled, LRRK2 and autophagy: a common pathway for disease
Open the PDF for LRRK2 and autophagy: a common pathway for disease in another window
Articles

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease

Available to Purchase
Elisa Greggio
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1058–1062.
https://doi.org/10.1042/BST20120054
Published: 19 September 2012
... orchestrated by LRRK2 and deregulated under pathological conditions. 1 email [email protected] 7 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophosphorylation GTPase leucine-rich repeat kinase 2 (LRRK2) moesin Parkinson's disease tau...
View articletitled, Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease
Open the PDF for Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease in another window
Articles

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models

Available to Purchase
Maximilian Sloan, Javier Alegre-Abarrategui, Richard Wade-Martins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1080–1085.
https://doi.org/10.1042/BST20120151
Published: 19 September 2012
... I. Kaganovich A. Beilina A. Taymans J.-M. Daniels V. Lewis P. Jain S. Ding J. Syed A. The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation J. Biol. Chem. 2008 283 16906 16914...
View articletitled, Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models
Open the PDF for Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models in another window
Articles

Phosphorylation of LRRK2: from kinase to substrate

Available to Purchase
Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1102–1110.
https://doi.org/10.1042/BST20120128
Published: 19 September 2012
... leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease phosphorylation In summary, accumulating evidence suggests that understanding cellular LRRK2 phosphorylation is crucial to obtain more insight into the function as well as dysfunction of LRRK2. However, to date, many questions remain...
View articletitled, Phosphorylation of LRRK2: from kinase to substrate
Open the PDF for Phosphorylation of LRRK2: from kinase to substrate in another window
Articles

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2

Available to Purchase
Youren Tong, Jie Shen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1042–1046.
https://doi.org/10.1042/BST20120112
Published: 19 September 2012
... to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease Biochemistry 2007 46 1380 1388 14 Smith W.W. Pei Z. Jiang H. Moore D.J. Liang Y. West A.B. Dawson V.L. Dawson T.M. Ross C.A. Leucine-rich repeat kinase 2 (LRRK2...
View articletitled, Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2
Open the PDF for Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2 in another window
Articles

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

Available to Purchase
Patrick A. Lewis, Dario R. Alessi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1039–1041.
https://doi.org/10.1042/BST20120178
Published: 19 September 2012
...). 2 Correspondence may be addressed to either author (email [email protected] or [email protected] ). 13 7 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer inflammatory bowel disease leprosy leucine-rich repeat kinase 2 (LRRK2...
View articletitled, Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease
Open the PDF for Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease in another window
Articles

Cellular reprogramming: a new approach to modelling Parkinson's disease

Available to Purchase
Elizabeth M. Hartfield, Hugo J.R. Fernandes, Jane Vowles, Sally A. Cowley, Richard Wade-Martins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1152–1157.
https://doi.org/10.1042/BST20120159
Published: 19 September 2012
... Biochemical Society 2012 induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease reprogramming The generation and differentiation of human iPSCs into neuronal cells is a field in fast expansion, not only for PD, but also for other neurodegenerative...
View articletitled, Cellular reprogramming: a new approach to modelling Parkinson's disease
Open the PDF for Cellular reprogramming: a new approach to modelling Parkinson's disease in another window
Articles

Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease

Available to Purchase
José M. Bravo-San Pedro, Rubén Gómez-Sánchez, Mireia Niso-Santano, Elisa Pizarro-Estrella, Rosa A. González-Polo, José M. Fuentes
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1129–1133.
https://doi.org/10.1042/BST20120095
Published: 19 September 2012
... domains and functional insights Trends Neurosci. 2006 29 286 293 12 Greggio E. Zambrano I. Kaganovich A. Beilina A. Taymans J.-M. Daniels V. Lewis P. Jain S. Ding J. Syed A. The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2...
View articletitled, Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease
Open the PDF for Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease in another window
Articles

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations

Available to Purchase
Ryan D. Mills, Terrence D. Mulhern, Heung-Chin Cheng, Janetta G. Culvenor
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1086–1089.
https://doi.org/10.1042/BST20120088
Published: 19 September 2012
... PSI-BLAST position-specific iterative basic local alignment search tool ROC Ras of complex proteins armadillo ankyrin GTPase leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease WD40 In 2004, two landmark reports first identified mutations in the large multi-domain...
View articletitled, Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations
Open the PDF for Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations in another window
Articles

The GTPase function of LRRK2

Available to Purchase
Jean-Marc Taymans
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1063–1069.
https://doi.org/10.1042/BST20120133
Published: 19 September 2012
... venues. 1 email [email protected] 11 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 G-protein cycle GTPase leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease Ras of complex proteins (ROC) LRRK2 (leucine-rich repeat...
View articletitled, The GTPase function of LRRK2
Open the PDF for The GTPase function of LRRK2 in another window
Articles

Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2

Available to Purchase
Elisa Belluzzi, Elisa Greggio, Giovanni Piccoli
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1111–1116.
https://doi.org/10.1042/BST20120124
Published: 19 September 2012
... therapeutic intervention. 1 Correspondence may be addressed to either of these authors (email [email protected] or [email protected] ). 2 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 dopamine leucine-rich repeat kinase 2 (LRRK2) Parkinson's...
View articletitled, Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2
Open the PDF for Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2 in another window
Articles

Pharmacological inhibition of LRRK2 cellular phosphorylation sites provides insight into LRRK2 biology

Available to Purchase
Jing Zhao, Spencer B. Hermanson, Coby B. Carlson, Steven M. Riddle, Kurt W. Vogel, Kun Bi, R. Jeremy Nichols
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1158–1162.
https://doi.org/10.1042/BST20120137
Published: 19 September 2012
... To whom correspondence should be addressed (email [email protected] ). 24 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 14-3-3 protein high-throughput screening leucine-rich repeat kinase 2 (LRRK2) phosphorylation Parkinson's disease...
View articletitled, Pharmacological inhibition of LRRK2 cellular phosphorylation sites provides insight into LRRK2 biology
Open the PDF for Pharmacological inhibition of LRRK2 cellular phosphorylation sites provides insight into LRRK2 biology in another window
Articles

An emerging role for LRRK2 in the immune system

Available to Purchase
Nicolas Dzamko, Glenda M. Halliday
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1134–1139.
https://doi.org/10.1042/BST20120119
Published: 19 September 2012
.... Jiang H. Moore D.J. Liang Y. West A.B. Dawson V.L. Dawson T.M. Ross C.A. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration Proc. Natl. Acad. Sci. U.S.A. 2005 102 18676 18681 4 Jaleel M. Nichols R.J...
View articletitled, An emerging role for LRRK2 in the immune system
Open the PDF for An emerging role for LRRK2 in the immune system in another window
Articles

A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2 , SNCA and MAPT BAC-transgenic mice

Available to Purchase
Sara J. Johnson, Richard Wade-Martins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 862–867.
https://doi.org/10.1042/BST0390862
Published: 20 July 2011
... chromosome transgenics (BAC transgenics) leucine-rich repeat kinase 2 (LRRK2) microtubule-associated protein tau neurodegeneration Parkinson's disease Protein distribution was investigated in BAC- WT LRRK2 transgenic mice using Western blotting and immunohistochemistry, and LRRK2 was found...
View articletitled, A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2 , SNCA and MAPT BAC-transgenic mice
Open the PDF for A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2 , SNCA and MAPT BAC-transgenic mice in another window