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Keywords: ligand
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Biochem Soc Trans (2015) 43 (5): 1095–1103.
Published: 09 October 2015
...-signalling complexes remain unperturbed. In this mini-review, we discuss how small molecules can reveal rate-limiting signalling outputs and functions of Tribs in cells and intact organisms, perhaps serving as guides for the development of new drugs. We predict that appropriate small molecule TRIB ligands...
Biochem Soc Trans (2004) 32 (3): 407–411.
Published: 01 June 2004
... cell anchorage and movement, but prevents aberrant trafficking and aggregation. Following ligand engagement, integrin signalling imposes a spatial constraint on the assembly of signalling complexes and controls the transduction of mechanical force to the cytoskeleton. This transmembrane passage...