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Keywords: ligand binding
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Biochem Soc Trans (2021) 49 (2): 645–661.
Published: 16 April 2021
... HGF/MET signaling is a driver of many cancers and contributes to drug resistance to several approved therapeutics targeting other RTKs, making MET itself an important drug target. In RTKs, homeostatic receptor signaling is dependent on autoinhibition in the absence of ligand binding and orchestrated...
Biochem Soc Trans (2013) 41 (1): 154–158.
Published: 29 January 2013
... for enhancement of binding affinity. Such insights will be useful in the rational development of drugs acting at this important group of targets. GPCR (G-protein-coupled receptor) ligand binding receptor conformation Class B GPCRs (G-protein-coupled receptors) share heptahelical topology...
Biochem Soc Trans (2012) 40 (2): 419–423.
Published: 21 March 2012
...Mikael Akke Protein conformational dynamics can be critical for ligand binding in two ways that relate to kinetics and thermodynamics respectively. First, conformational transitions between different substates can control access to the binding site (kinetics). Secondly, differences between free...
Biochem Soc Trans (2011) 39 (2): 647–651.
Published: 22 March 2011
... this occurs through a conformational change in the ligand-binding domain that leads to the stabilization of one of several mutually exclusive secondary structures in the downstream element [ 17 , 18 ]. 8 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 bis-(3′–5...
Biochem Soc Trans (2007) 35 (4): 707–708.
Published: 20 July 2007
...D.R. Poyner; M. Wheatley In April 2007, the Biochemical Society held a meeting to compare and contrast ligand binding and activation of Family A and B GPCRs (G-protein-coupled receptors). Being the largest class, Family A GPCRs usually receive the most attention, although a previous Biochemical...
Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor The superfamily of guanine nucleotide-binding protein (G-protein)-coupled receptors represents the largest group of cell membrane receptors...
Biochem Soc Trans (2004) 32 (5): 721–723.
Published: 26 October 2004
... intramolecular contacts between the propeller domain and the central LA repeats of the ligand-binding domain, suggesting that the receptor changes its overall shape from extended to closed, in response to pH. Here we discuss how the LDLR uses flexibility and rigidity of linkers between modules to facilitate...
Biochem Soc Trans (2003) 31 (5): 973–979.
Published: 01 October 2003
... be addressed (e-mail r.palmer@pgen.net ). Intermolecular Associations in 2D and 3D, a Biochemical Society Focused Meeting held at University of Nottingham, 19–20 June 2003 18 May 2003 © 2003 Biochemical Society 2003 electron density ligand binding multiple isomorphous replacement...
Biochem Soc Trans (2003) 31 (5): 1010–1014.
Published: 01 October 2003
... the introduction of frontal gel filtration for the study of protein self-association to the characterization of ligand binding by the biosensor variant of quantitative affinity chromatography. 1 e-mail d.winzor@mailbox.uq.edu.au Intermolecular Associations in 2D and 3D, a Biochemical Society Focused...
Biochem Soc Trans (2003) 31 (1): 56–59.
Published: 01 February 2003
...E.H. Kong; A.C.W. Pike; R.E. Hubbard We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex...
Biochem Soc Trans (2000) 28 (4): 396–400.
Published: 01 August 2000
...A. C. W. Pike; A. M. Brzozowski; J. Walton; R. E. Hubbard; T. Bonn; J-Å. Gustafsson; M. Carlquist We have determined the three-dimensional structures of both α- and β-forms of the ligand-binding domain of the oestrogen receptor (ER) in complexes with a range of receptor agonists and antagonists...