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1-11 of 11
Keywords: ligand binding
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Articles
State of the structure address on MET receptor activation by HGF
Available to PurchaseEdmond M. Linossi, Gabriella O. Estevam, Masaya Oshima, James S. Fraser, Eric A. Collisson, Natalia Jura
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 645–661.
Published: 16 April 2021
... HGF/MET signaling is a driver of many cancers and contributes to drug resistance to several approved therapeutics targeting other RTKs, making MET itself an important drug target. In RTKs, homeostatic receptor signaling is dependent on autoinhibition in the absence of ligand binding and orchestrated...
Articles
The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 154–158.
Published: 29 January 2013
... and validity of these approaches. This work is only the beginning of efforts to utilize these insights for the development of drugs targeting the orthosteric ligand-binding site of members of this important family. G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms...
Articles
Conformational dynamics and thermodynamics of protein–ligand binding studied by NMR relaxation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 419–423.
Published: 21 March 2012
...Mikael Akke Protein conformational dynamics can be critical for ligand binding in two ways that relate to kinetics and thermodynamics respectively. First, conformational transitions between different substates can control access to the binding site (kinetics). Secondly, differences between free...
Articles
Interactions of the c-di-GMP riboswitch with its second messenger ligand
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 647–651.
Published: 22 March 2011
... ligand binding riboswitch signalling Other binding pocket nucleotides, specifically those in the J1/2 segment, are tolerant of mutation except in cases in which the sequence becomes complementary to other regions in the RNA and promotes misfolding of the riboswitch. The clearest example...
Articles
Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor Fluorescence techniques can provide complementary insights into the environment of indicators that can be situated at distinct sites throughout...
Articles
Family Resemblances? Ligand Binding and Activation of Family A and B G-Protein-Coupled Receptors
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 707–708.
Published: 20 July 2007
...D.R. Poyner; M. Wheatley In April 2007, the Biochemical Society held a meeting to compare and contrast ligand binding and activation of Family A and B GPCRs (G-protein-coupled receptors). Being the largest class, Family A GPCRs usually receive the most attention, although a previous Biochemical...
Articles
Structural features of the low-density lipoprotein receptor facilitating ligand binding and release
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 721–723.
Published: 26 October 2004
... intramolecular contacts between the propeller domain and the central LA repeats of the ligand-binding domain, suggesting that the receptor changes its overall shape from extended to closed, in response to pH. Here we discuss how the LDLR uses flexibility and rigidity of linkers between modules to facilitate...
Articles
The development of chromatography for the characterization of protein interactions: a personal perspective
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 1010–1014.
Published: 01 October 2003
... the introduction of frontal gel filtration for the study of protein self-association to the characterization of ligand binding by the biosensor variant of quantitative affinity chromatography. 1 e-mail [email protected] Intermolecular Associations in 2D and 3D, a Biochemical Society Focused...
Articles
X-ray crystallographic studies of protein–ligand interactions
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 973–979.
Published: 01 October 2003
... be addressed (e-mail [email protected] ). Intermolecular Associations in 2D and 3D, a Biochemical Society Focused Meeting held at University of Nottingham, 19–20 June 2003 18 May 2003 © 2003 Biochemical Society 2003 electron density ligand binding multiple isomorphous replacement...
Articles
Structure and mechanism of the oestrogen receptor
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 56–59.
Published: 01 February 2003
...E.H. Kong; A.C.W. Pike; R.E. Hubbard We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex...
Articles
Structural aspects of agonism and antagonism in the oestrogen receptor
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (4): 396–400.
Published: 01 August 2000
...A. C. W. Pike; A. M. Brzozowski; J. Walton; R. E. Hubbard; T. Bonn; J-Å. Gustafsson; M. Carlquist We have determined the three-dimensional structures of both α- and β-forms of the ligand-binding domain of the oestrogen receptor (ER) in complexes with a range of receptor agonists and antagonists...