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Keywords: ligand binding
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Biochem Soc Trans (2021) 49 (2): 645–661.
Published: 16 April 2021
... HGF/MET signaling is a driver of many cancers and contributes to drug resistance to several approved therapeutics targeting other RTKs, making MET itself an important drug target. In RTKs, homeostatic receptor signaling is dependent on autoinhibition in the absence of ligand binding and orchestrated...
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Biochem Soc Trans (2013) 41 (1): 154–158.
Published: 29 January 2013
... receptor demonstrate the utility and validity of these approaches. This work is only the beginning of efforts to utilize these insights for the development of drugs targeting the orthosteric ligand-binding site of members of this important family. G-Protein-Coupled Receptors: from Structural...
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Biochem Soc Trans (2011) 39 (2): 647–651.
Published: 22 March 2011
... compilation © 2011 Biochemical Society 2011 bis-(3′–5′)-cyclic dimeric GMP (c-di-GMP) guanine ligand binding riboswitch signalling The dinucleotide c-di-GMP [bis-(3′–5′)-cyclic dimeric guanosine monophosphate] functions as an important second messenger signalling molecule in bacteria. Many...
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Biochem Soc Trans (2003) 31 (5): 1010–1014.
Published: 01 October 2003
... the introduction of frontal gel filtration for the study of protein self-association to the characterization of ligand binding by the biosensor variant of quantitative affinity chromatography. 1 e-mail d.winzor@mailbox.uq.edu.au Intermolecular Associations in 2D and 3D, a Biochemical Society Focused...
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Biochem Soc Trans (2003) 31 (5): 973–979.
Published: 01 October 2003
... be addressed (e-mail r.palmer@pgen.net ). Intermolecular Associations in 2D and 3D, a Biochemical Society Focused Meeting held at University of Nottingham, 19–20 June 2003 18 May 2003 © 2003 Biochemical Society 2003 electron density ligand binding multiple isomorphous replacement...
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Biochem Soc Trans (2003) 31 (1): 56–59.
Published: 01 February 2003
...E.H. Kong; A.C.W. Pike; R.E. Hubbard We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex...
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Biochem Soc Trans (2000) 28 (4): 396–400.
Published: 01 August 2000
...A. C. W. Pike; A. M. Brzozowski; J. Walton; R. E. Hubbard; T. Bonn; J-Å. Gustafsson; M. Carlquist We have determined the three-dimensional structures of both α- and β-forms of the ligand-binding domain of the oestrogen receptor (ER) in complexes with a range of receptor agonists and antagonists...