... and G-protein coupled receptors and the relative differences in exposure of extracellular loops and domains that can be targeted by antibodies Shown here are a voltage-gated calcium channel (VGCC), the P2X4 ligand-gated ion channel and a GPCR, CXCR4. A structure of an IgG is shown to scale. Structures...

... involvement of ligand-gated ion channels in the process of epileptogenesis. 1 To whom correspondence should be addressed (email [email protected] ). 31 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 adult neurogenesis hippocampus...

...Sarah C.R. Lummis The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABA A and GABA C receptors...

...S.C.R. Lummis The 5-HT 3 (5-hydroxytryptamine) receptor is a typical member of the Cys-loop family of ligand-gated ion channels. No atomic resolution structures of these proteins have yet been published, and thus structure–function relationships in this family of proteins have been largely...

...C.N. Connolly; K.A. Wafford The Cys-loop receptors constitute an important superfamily of LGICs (ligand-gated ion channels) comprising receptors for acetylcholine, 5-HT 3 (5-hydroxytryptamine; 5-HT 3 receptors), glycine and GABA (γ-aminobutyric acid; GABA A receptors). A vast knowledge...