... microenvironment. In turn, proteins such as lipid-metabolizing enzymes and lipid-transfer proteins control metabolism and trafficking of membrane lipids, resulting in complex networks of lipids and proteins [ 3 , 4 ]. In the past century, studies have revealed dozens of lipid-metabolizing enzymes...

... ]. Correspondence: Eric A. Ortlund ( [email protected] ) 8 7 2024 2 8 2024 5 8 2024 coenzyme A lipid metabolism lipid transfer Lipids perform multiple essential cellular roles that include metabolic signaling, energy storage, and membrane formation. Lipids are distributed...

...). Published by Portland Press Limited on behalf of the Biochemical Society 2023 acid-base balance chronic kidney disease gluconeogenesis inflammation lipid metabolism renal physiology Chronic kidney disease (CKD) is clinically defined as reduced kidney function or a structural abnormality...

.... In view of the emerging role of circadian regulation in maintaining lipid homeostasis, in this review, we summarize the current knowledge on lipid metabolic pathways controlled by the mammalian circadian system. Furthermore, we review the emerging connection between the development of human metabolic...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . lipid metabolism lipid-binding domains membranes phosphatidylinositol polyunsaturated fatty acids signalling Phosphoinositides (PIPn) are a family of eight phospholipids (PI, PI3P, PI4P, PI5P, PI(4,5)P 2 , PI(3,4)P 2...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ATP-binding cassette transporters cardiovascular disease cholesterol transport lipid metabolism sitosterolemia structural biology ABCG5 and ABCG8 genes are situated head-to-head on opposite strands...

... TRIB1 locus as being significantly associated with multiple plasma lipid traits and cardiovascular disease (CVD) in humans. The involvement of TRIB1 in hepatic lipid metabolism has been validated through viral-mediated hepatic overexpression of the gene in mice; increasing levels of TRIB1 decreased...

.... Clevers H. Cell biology. The unusual case of porcupine Science 2012 337 922 923 10.1126/science.1228179 22923569 Figure 2 Mechanisms underlying MBOAT acyl donor selectivity Wnt fatty acylation by the Porcn enzyme is modelled here. intercellular signalling lipid...

... Cdc48/VCP/p97 endoplasmic-reticulum–mitochondria encounter structure (ERMES) lipid metabolism mitochondria mitophagy small GTPase The communication between organelles of the secretory pathway is an essential part of the life of any eukaryote. Transport containers are formed at one organelle...

... the experimental evidence for histone variant functions in lipid metabolism. 1 Correspondence may be addressed to either of these authors (email [email protected] or [email protected] / [email protected] ) . 30 4 2014 © The Authors Journal compilation © 2014...

... complement system disease modelling genome-wide association study (GWAS) lipid metabolism The recent advances in AD (Alzheimer's disease) genetics brought several new players to the pathways involved in this already complex disease. Currently, many groups are working to understand the individual...

... [email protected] ). 27 6 2006 © 2006 The Biochemical Society 2006 adrenal gland cholesterol corticosterone lipid metabolism liver X receptor (LXR) nuclear receptor The nuclear hormone receptor superfamily is a large family of transcription factors consisting of 48...

..., regulation of neutral lipid metabolism, control of signalling cascades, regulation of secretory vesicle generation, and function in the microtubule-based motility of endo/lysosomes. Some of these functions could involve ERJ and non-vesicular transport of lipids, but this is unlikely to be the unifying...

... homology to Sec14p and together they form the Sec14p family of lipid-transfer proteins. It is a diverse group of proteins with distinct subcellular localizations and varied physiological functions related to lipid metabolism and membrane trafficking. Sfh1p is the most homologous protein to Sec14p...

... factor linking the clinical manifestations of the metabolic syndrome. 1 To whom correspondence should be addressed (email [email protected] ). 20 6 2005 © 2005 The Biochemical Society 2005 energy balance homoeostasis insulin resistance lipid metabolism mouse model...

... correspondence should be addressed (email [email protected] ). 31 5 2005 © 2005 The Biochemical Society 2005 biosynthetic pathway co-regulation ergosterol lipid metabolism long-chain fatty acid sphingolipid Sterols are essential structural and regulatory components...

... College, Oxford, 7–11 September 2003 5 August 2003 © 2004 Biochemical Society 2004 bile acid gene transcription glucose metabolism lipid metabolism nuclear receptor Abbreviations used: ABCA1, ATP binding cassette A1; BARE, bile acid-responsive element; CYP7A1...

... on the Bioscience of Lipids, a meeting held at Keble College, Oxford, 7–11 September 2003 7 September 2003 © 2004 Biochemical Society 2004 hepatocyte nuclear factor-4 (HNF-4) lipid metabolism lipogenesis sterol regulatory element-binding protein 1c (SREBP-1c) Abbreviations used...

... be addressed (e-mail [email protected] ) 26 6 2000 © 2000 Biochemical Society 2000 lipid metabolism protein interactions LOX, lipoxygenase PP2A, protein phosphatase 2A HMM, high-molecular-mass FC, fusicoccin 13-HPOD, 13-hydroxy-9Z,11 E-octadecadieonic acid 9-HPOD, 9...