...Magali Walravens; Ine Koeken; Tom Vanden Berghe Pathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic...

...Yeping Wu; Ye-Wheen Lim; Robert G. Parton Oxidative stress is a feature of many disease conditions. Oxidative stress can activate a number of cellular pathways leading to cell death, including a distinct iron-dependent pathway involving lipid peroxidation, termed ferroptosis, but cells have evolved...

...Helene Nehring; Svenja Meierjohann; Jose Pedro Friedmann Angeli Lipid peroxidation has been associated with a wide array of (patho)physiological conditions. Remarkably, in the last few years, a novel cell death modality termed ferroptosis was recognized as a process initiated by iron-dependent...

...+ -influx to astrocytes [ 13 ]. amyloid astrocyte glutathione lipid peroxidation NADPH oxidase poly(ADP-ribose) polymerase (PARP) Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes a progressive and irreversible loss of higher brain functions and ultimately...

... is available for lipid peroxidation products, including TBARSs (thiobarbituric acid-reactive substances), lipid hydroperoxides, hydroxylated fatty acids, volatile hydrocarbons, aldehydes and cholesterol auto-oxidation products, protein carbonyls, aldehyde-modified proteins, oxidatively damaged DNA and total...

.... Investigation of potential mechanisms by which lack of dietary vitamin E may lead to clinically relevant pathological changes in colon tissue was conducted using gene expression profiling strategies on vitamin E-sufficient and -deficient rats. Morphological changes and increased indices of lipid peroxidation...

... sphingomyelinase activity, sphingomyelin and ceramide contents, and the level of lipid peroxide products (conjugated dienes), in the cerebral cortex, hippocampus and cerebellum of rats within 3 h and 7 days of intracerebral injection of A-β and TNF-α. A single injection of A-β and TNF-α has been shown to increase...

... lipid peroxidation low-density lipoprotein vitamin E Abbreviations used: LDL, low-density lipoprotein; HPODE, hydroperoxyoctadecadienoate; MPO, myeloperoxidase; apoB, apolipoprotein B-100. 156 Biochemical Society Transactions (2004) Volume 32, part 1 Antioxidants and atherosclerosis E...

... carbonyl compound N ε -(carboxymethyl)lysine N ε -(carboxyethyl)lysine lipid peroxidation Abbreviations used: AGE, advanced glycation end product; ALE, advanced lipoxidation end product; CEL, N ∊ -(carboxyethyl)lysine; CML, N ∊ -(carboxymethyl)lysine; DBI, double bond index; FA, fatty...

... of the antioxidant glutathione, indicating the role of oxidative stress in their toxicity. K562 cells loaded with eicosapentaenoic acid, a fatty acid particularly susceptible to oxidation, were also more sensitive to the toxic effects of the Fe complexes, and toxicity was proportional to lipid peroxidation. Thus...

... mechanisms by which CLA-enriched milk fat exerts its anti-carcinogenic effects. An oxidative mechanism appears to be involved in its growth-suppressive effects, since supplementation of growth culture medium with CLA (17–71.5 μM) made breast cancer cells more susceptible to lipid peroxidation. Studies have...

... 2001 Biochemical Society 2001 antioxidants atherogenesis LDL lipid peroxidation apo B, apolipoprotein B LDL, low-density lipoprotein oxLDL, oxidized LDL PUFA, polyunsaturated fatty acid Biochemical Society Transactions (200 I), Volume 29, part 2 Lipoprotein oxidation...