...-derived vacuole with a sterol-rich membrane containing host and bacterial proteins. The CCV membrane itself serves as a barrier to protect the bacteria from the host’s innate immune response, and the lipid and protein content directly influence both the CCV luminal environment and interactions between...

... summarized how anionic lipids have come to be involved in viral fusion and how the endosomal resident anionic lipid BMP has become increasingly implicated as an important cofactor for those viruses that fuse via the endocytic pathway. Correspondence: Jinwoo Lee ( [email protected] ) 11 11 2024...

... the use of RMs for aqueous proteins. Protein-optimized RM formulations enabled encapsulation of challenging membrane associated protein types, including lipidated proteins, transmembrane proteins, and peripheral membrane proteins. Improvements in biological accuracy of RMs using phospholipid-based...

... 2i/LIF medium has provided solutions to some of these challenges, prolonged culturing of these cells, especially female ESCs, raises concerns related to genome integrity. This review discusses the pivotal role of lipids in genome stability and pluripotency of stem cells. Notably, the introduction...

... first, then present new information on how this important cycle forms a central regulatory node connecting fatty acyl and phospholipid metabolism and how its altered regulation may present new opportunities for therapeutic intervention in human disease. lipids membranes phospholipids MBOATs...

...Ryan Brady; Nicola J. Harris; Grant A. Pellowe; Samuel Gulaidi Breen; Paula J. Booth Membrane proteins need to fold with precision in order to function correctly, with misfolding potentially leading to disease. The proteins reside within a hydrophobic lipid membrane and must insert...

... with signaling at the plasma membrane, PI(3,4)P 2 is gaining increasing traction as a signaling lipid and has been implicated in controlling Akt activity throughout the endomembrane system. This has clear implications for the phosphorylation of both freely diffusible substrates and those localized to discrete...

...Monica Napolitano The G protein-coupled receptors (GPCRs) constitute a large superfamily of seven transmembrane-spanning receptors that are activated by several classes of ligands, including bioactive lipids. GPCRs are attractive therapeutic targets for the treatment of human diseases...

...Tamako Nishimura; Nobuhiro Morone; Shiro Suetsugu Lipid membranes are structural components of cell surfaces and intracellular organelles. Alterations in lipid membrane shape are accompanied by numerous cellular functions, including endocytosis, intracellular transport, and cell migration. Proteins...

...John L. Harwood Lipids are key molecules for membranes, energy storage and signalling. I have been privileged to have worked in such a diverse field and in organisms from microbes to humans. Here I will describe some of those contrasting areas which range from environmental impacts to food...

...Endre Kiss-Toth; Guillermo Velasco; Warren S. Pear 1 To whom correspondence should be addressed (email [email protected] ) . 2 6 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer lipids metabolism signalling tribbles ubiquitin...

...J. Shepherd The evidence linking cholesterol levels in the blood to vascular risk is now incontrovertible and the introduction of HMG CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitor (or statin) therapy into clinical practice has now revolutionized the management of lipid disorders...

...A. Smaoui; A. Chérif Cotton plants ( Gossypium hirsutum L. cv. S4) were grown and irrigated with increasing salt concentrations: 0, 50, 100 and 150 mM NaCl. Lipids from developing seeds, at stages of 3, 4, 5 and 6 weeks after anthesis, were analysed. High salt dose (150 mM NaCl) affected...

...Z. Várkonyi; O. Zsiros; T. Farkas; G. Garab; Z. Gombos Acyl-lipid desaturation introduces double bonds (unsaturated bonds) at specifically defined positions of fatty acids that are esterified to the glycerol backbone of membrane glycerolipids. Desaturation patterns of the glycerolipids...