...) is enhanced by Nrf2 in cancers and aids their growth. PPP has also been found to be up-regulated in non-cancer tissues and other pathways, such as de novo lipogenesis, have been found to be repressed after activation of the Nrf2 pathway. The importance of these Nrf2-regulated metabolic pathways in cancer...

... of this molecule. These findings reveal new mechanisms by which processes such as growth, lipogenesis and insulin resistance can be differentially regulated and may suggest novel strategies for treating insulin-linked diseases. 1 To whom correspondence should be addressed (email [email protected]...

... on the Bioscience of Lipids, a meeting held at Keble College, Oxford, 7–11 September 2003 7 September 2003 © 2004 Biochemical Society 2004 hepatocyte nuclear factor-4 (HNF-4) lipid metabolism lipogenesis sterol regulatory element-binding protein 1c (SREBP-1c) Abbreviations used...

...-related protein gluconeogenesis hepatocyte nuclear factor 4α lipogenesis sterol-regulatory-element-binding protein-1c Abbreviations used: ACC, acetyl-CoA carboxylase; AICAR, 5-amino-4-imidazolecarboxamide riboside; AMPK, AMP-activated protein kinase; b-HLH-LZ, basic domain–helix–loop–helix...

... adipocyte differentiation fatty acid oxidation lipogenesis DR, direct repeat GLUT, glucose transporter LBD, ligand-binding domain PGD 2 , prostaglandin D 2 PI 3 -kinase, phosphatidylinositol 3-kinase PPAR, peroxisome proliferator-activated receptor PPRE, peroxisome proliferator-response...

... of each SREBP isoform and how the actions of each SREBP isoform enable cells to tightly regulate lipid homoeostasis. SREBP structure and activation SREBPs belong to the basic-helix-loop-helix- leucine zipper (bHLH-Zip) family of transcrip- ~~ ~ Key words: cholesterol, fatty acids, lipogenesis...

...J. Kopecký; M. Rossmeisl; P. Flachs; K. Bardová; P. Brauner Metabolism of white adipose tissue is involved in the control of body fat content. In vitro experiments indicated a dependence of lipogenesis on mitochondrial ATP production, as well as a reciprocal link between hormonal effects...