... © 2008 Biochemical Society 2008 glucose-stimulated insulin secretion insulin secretion lipotoxicity pancreatic β-cell protein kinase C (PKC) Type 2 diabetes The PKC (protein kinase C) family of serine/threonine protein kinases comprises a total of ten isoforms, and is subdivided...

... progress in the field of ER stress in pancreatic β-cells. Recent advances in the understanding of lipotoxic ER stress and β-cell recovery from ER stress are discussed. The ER stress response is an important adaptive cellular signalling response in cells with high secretory activity. It aims to balance...

... of ROS and are also the primary target of oxidative attacks. The present review presents the current knowledge of lipotoxicity related to oxidative stress in the context of mitochondrial function in the β-cell. Pancreatic β-cells are poised to sense glucose and other nutrient secretagogues to regulate...

... LSHM-CT-2006-518153 and STREP SaveBeta contract 036903 in the Framework Programme 6 (FP6) of the European Community] and by the Fonds National de la Recherche Scientifique (FNRS) – Fonds de la Recherche Scientifique Médicale (FRSM). Owing to space restrictions, many papers on lipotoxicity in Type 2...

... in mitochondrial function in adipose cells seems to result in an inappropriate scavenging of fatty acids by β-oxidation. As a consequence, a systemic overload with fatty acids occurs, leading to an enhanced decline in β-cell function due to lipotoxicity. 1 To whom correspondence should be addressed...