...-liquid phase separation state caused by these repeat RNAs and repeat polypeptides, as well as potential therapeutic approaches against repeat expansion diseases. liquid-liquid phase separation neurodegeneration RAN translation repeat expansion diseases The human genome contains many simple...

...Pinaki Swain; Stephanie C. Weber Biomolecular condensates comprise a diverse and ubiquitous class of membraneless organelles. Condensate assembly is often described by liquid–liquid phase separation. While this process explains many key features, it cannot account for the compositional...

... different conditions, their biological functions and physical properties are poorly understood. Recent intriguing data suggest that liquid–liquid phase separation (LLPS) represents an important mechanism seeding the formation and defining the function of RNPBs. In this review, we discuss how LLPS...