1-17 of 17
Keywords: liver
Close
Sort by
Articles
Biochem Soc Trans (2021) 49 (2): 579–590.
Published: 05 March 2021
... a transformative agreement with JISC. liver pancreas reprogramming transcription factor transdifferentiation The history of cell reprogramming, or the manipulation of cellular identity, spans a century of technological and conceptual innovation across developmental biology, biochemistry...
Articles
Articles
Biochem Soc Trans (2012) 40 (1): 133–138.
Published: 19 January 2012
...David C. Clarke; Douglas A. Lauffenburger Inflammation is a key physiological response to infection and injury and, although usually beneficial, it can also be damaging to the host. The liver is a prototypical example in this regard because inflammation helps to resolve liver injury, but it also...
Articles
Biochem Soc Trans (2010) 38 (6): 1553–1557.
Published: 24 November 2010
... of differentiation. miR - 122 is a highly liver-specific miRNA that is important in hepatitis C virus infection, cholesterol metabolism and hepatocellular carcinoma. In the present review, we discuss the effects of miR - 122 on liver physiology and pathology. Recent evidence of pathways involved in the regulation...
Articles
Biochem Soc Trans (2008) 36 (6): 1233–1238.
Published: 19 November 2008
...Svetlana Lutsenko Wilson's disease is a severe human disorder of copper homoeostasis. The disease is associated with various mutations in the ATP7B gene that encodes a copper-transporting ATPase, and a massive accumulation of copper in the liver and several other tissues. The most frequent disease...
Articles
Articles
Biochem Soc Trans (2008) 36 (5): 848–852.
Published: 19 September 2008
... in methionine metabolism occur in several animal models of alcoholic liver injury, and it is also altered in patients with liver disease. Both high and low levels of SAMe predispose to liver injury. In this regard, knockout mouse models have been developed for the enzymes responsible for SAMe synthesis...
Articles
Biochem Soc Trans (2007) 35 (5): 1171–1174.
Published: 25 October 2007
.... Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action. 1 To whom correspondence should be addressed...
Articles
Biochem Soc Trans (2007) 35 (5): 1175–1179.
Published: 25 October 2007
... ]. 1 To whom correspondence should be addressed (email [email protected] ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 betaine cystathionine β-synthase diabetes insulin resistance liver trans-sulfuration Since the observation, by McCully...
Articles
Articles
Biochem Soc Trans (2006) 34 (6): 1119–1123.
Published: 25 October 2006
...M.C. Wright The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic...
Articles
Biochem Soc Trans (2005) 33 (2): 371–374.
Published: 01 April 2005
...B. Leighton; A. Atkinson; M.P. Coghlan The monomeric enzyme GK (glucokinase) has a low affinity for glucose and, quantitatively, is largely expressed in the liver and pancreatic β-cells, playing a key ‘glucose sensing’ role to regulate hepatic glucose balance and insulin secretion. Mutations of GK...
Articles
Biochem Soc Trans (2005) 33 (1): 311–315.
Published: 01 February 2005
... peripherally, while it appears impaired in the liver [Goudriaan, Dahlmans, Teusink, Ouwens, Febbraio, Maassen, Romijn, Havekes, and Voshol (2003) J. Lipid. Res. 44 , 2270–2277; and Hajri, Han, Bonen and Abumrad (2002) J. Clin. Invest. 109 , 1381–1389]. Tissues such as muscle, which normally express high levels...
Articles
Biochem Soc Trans (2002) 30 (4): 800–802.
Published: 01 August 2002
... representative of the tissue from which they derive. 1 To whom correspondence should be addressed, at Xcellsyz Ltd (E-mail [email protected] ) 9 4 2002 © 2002 Biochemical Society 2002 adipocytes liver muscle t-antigen Biochemical Society Transactions (2002) Volume 30, part 4...
Articles
Biochem Soc Trans (2002) 30 (2): 51–54.
Published: 01 April 2002
...David Tosh; Chia-Ning Shen; Jonathan M. W. Slack Transdifferentiation is the name used to describe the conversion of one differentiated cell type to another. During development, the liver and pancreas arise from the same region of the endoderm and cells from the two organs can transdifferentiate...
Articles
Biochem Soc Trans (2001) 29 (4): 547–552.
Published: 01 August 2001
...P. Ferré; M. Foretz; D. Azzout-Marniche; D. Bécard; F. Foufelle Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expression...
Articles
Biochem Soc Trans (2001) 29 (2): 272–278.
Published: 01 May 2001
...-mail [email protected] ) 13 11 2000 © 2001 Biochemical Society 2001 heart liver muscle peroxisome-proliferator-activated receptor α pyruvate dehydrogenase pyruvate dehydrogenase kinase CPT, carnitine palmitoyltransferase FA, fatty acid PDC, pyruvate dehydrogenase complex PDK...