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1-17 of 17
Keywords: liver
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 579–590.
Published: 05 March 2021
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. liver pancreas reprogramming transcription factor transdifferentiation The history of cell reprogramming, or the manipulation of cellular identity, spans a century of technological and conceptual...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 609–616.
Published: 22 May 2014
... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 liver metaplasia pancreas reprogramming transdifferentiation Figure 1 Proposed mechanism for dexamethasone-dependent transdifferentiation of pancreatic B13 cells into hepatocyte-like cells Dexamethasone (Dex...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 133–138.
Published: 19 January 2012
...David C. Clarke; Douglas A. Lauffenburger Inflammation is a key physiological response to infection and injury and, although usually beneficial, it can also be damaging to the host. The liver is a prototypical example in this regard because inflammation helps to resolve liver injury, but it also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1553–1557.
Published: 24 November 2010
... of differentiation. miR - 122 is a highly liver-specific miRNA that is important in hepatitis C virus infection, cholesterol metabolism and hepatocellular carcinoma. In the present review, we discuss the effects of miR - 122 on liver physiology and pathology. Recent evidence of pathways involved in the regulation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1233–1238.
Published: 19 November 2008
...Svetlana Lutsenko Wilson's disease is a severe human disorder of copper homoeostasis. The disease is associated with various mutations in the ATP7B gene that encodes a copper-transporting ATPase, and a massive accumulation of copper in the liver and several other tissues. The most frequent disease...
Articles
Nuria Martínez-López, Marta Varela-Rey, Usue Ariz, Nieves Embade, Mercedes Vazquez-Chantada, David Fernandez-Ramos, Laura Gomez-Santos, Shelly C. Lu, Jose M. Mato, Maria L. Martinez-Chantar
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 848–852.
Published: 19 September 2008
... in methionine metabolism occur in several animal models of alcoholic liver injury, and it is also altered in patients with liver disease. Both high and low levels of SAMe predispose to liver injury. In this regard, knockout mouse models have been developed for the enzymes responsible for SAMe synthesis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 920–929.
Published: 19 September 2008
... of NADPH oxidases. Several NOX isoforms are expressed in the liver and pancreatic β-cells. There is now evidence that inappropriate activation of NOX enzymes may damage the liver and pancreatic β-cells. In the context of the metabolic syndrome, the emerging epidemic of non-alcoholic steatohepatitis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1171–1174.
Published: 25 October 2007
.... Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action. 1 To whom correspondence should be addressed...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1175–1179.
Published: 25 October 2007
... resistance liver trans-sulfuration Since the observation, by McCully [ 1 ], of severe arteriosclerotic lesions in children with HHcy (hyperhomocysteinaemia) and homocysteinuria, a large number of studies have linked moderate HHcy to atherosclerotic disease. Mean plasma tHcy [total Hcy (homocysteine...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 440–441.
Published: 22 May 2007
... types of remnants. These findings indicate that the type of fat in the diet directly affects VLDL lipid secretion on delivery to the liver in chylomicron remnants. 1 To whom correspondence should be addressed (email [email protected] ). 18 12 2007 © 2007 Biochemical Society 2007...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1119–1123.
Published: 25 October 2006
...M.C. Wright The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (2): 371–374.
Published: 01 April 2005
...B. Leighton; A. Atkinson; M.P. Coghlan The monomeric enzyme GK (glucokinase) has a low affinity for glucose and, quantitatively, is largely expressed in the liver and pancreatic β-cells, playing a key ‘glucose sensing’ role to regulate hepatic glucose balance and insulin secretion. Mutations of GK...
Articles
CD36-dependent fatty acid uptake regulates expression of peroxisome proliferator activated receptors
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 311–315.
Published: 01 February 2005
... peripherally, while it appears impaired in the liver [Goudriaan, Dahlmans, Teusink, Ouwens, Febbraio, Maassen, Romijn, Havekes, and Voshol (2003) J. Lipid. Res. 44 , 2270–2277; and Hajri, Han, Bonen and Abumrad (2002) J. Clin. Invest. 109 , 1381–1389]. Tissues such as muscle, which normally express high levels...
Articles
Conditionally immortalized cell lines as model systems for high-throughput biology in drug discovery
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 800–802.
Published: 01 August 2002
... representative of the tissue from which they derive. 1 To whom correspondence should be addressed, at Xcellsyz Ltd (E-mail [email protected] ) 9 4 2002 © 2002 Biochemical Society 2002 adipocytes liver muscle t-antigen Biochemical Society Transactions (2002) Volume 30, part 4...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (2): 51–54.
Published: 01 April 2002
...David Tosh; Chia-Ning Shen; Jonathan M. W. Slack Transdifferentiation is the name used to describe the conversion of one differentiated cell type to another. During development, the liver and pancreas arise from the same region of the endoderm and cells from the two organs can transdifferentiate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 547–552.
Published: 01 August 2001
...P. Ferré; M. Foretz; D. Azzout-Marniche; D. Bécard; F. Foufelle Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expression...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 272–278.
Published: 01 May 2001
... interactions to the longer term. We discuss potential targets for substrate-mediated transcriptional regulation in relation to selective PDK isoform expression and the influence of altered PDK isoform expression in fuel sensing, selection and utilization. heart liver muscle peroxisome-proliferator...