... and blood, including circulating lymphocytes. Lymphocytes are a very heterogeneous group of white blood cells, consisting of subtypes that have different functions in immunity. Importantly, exercise drastically changes the lymphocyte composition in blood by increasing the numbers of some subsets, while...

...Martin Turner; Elena Vigorito miRs (microRNAs) post-transcriptionally regulate gene expression mainly by repressing translation or by inducing mRNA degradation. Dicer, an enzyme responsible for miR biogenesis, is required for T-cell function, suggesting regulatory roles for miRs in lymphocytes...

... of p110γ-knockout mice have shown an essential function for this isoform in chemotaxis of neutrophils and macrophages both in vitro and in vivo . However, the roles of p110γ and other PI3K enzymes and regulatory subunits in lymphocyte motility have been more difficult to discern. Recent studies...

... cycle 25) domain. RasGRP1 also possesses a DAG (diacylglycerol)-binding C1 domain and a pair of EF hands that bind calcium. RasGRP1 is selectively expressed in lymphocytes as well as in some cells of the brain, kidney and skin. Functional analysis supports the hypothesis that RasGRP1 serves to couple...

... receptor ligand identification lymphocyte natural killing 1 Correspondence should be addressed at Hlavova 8, CZ-12840 Praha 2, Czech Republic (email [email protected] ). 2 7 2004 © 2004 The Biochemical Society 2004 NK cells natural killer cells We...

...D.A. Fruman The PI3K (phosphoinositide 3-kinase) signalling pathway promotes proliferation and transformation in many cell types. This is particularly well illustrated by studies of primary lymphocytes and their leukaemic counterparts. PI3K activation is required for proliferation of T cells and B...

...) lymphocyte mast cell neutrophil phosphoinositide 3-kinase (PI 3-kinase) Abbreviations used: ARDS, acute respiratory distress syndrome; Bad, Bcl-2/Bcl-X L -antagonist, causing cell death; Bcl-2, B-cell leukaemia/lymphoma 2; COPD, chronic obstructive pulmonary disease; EPO, eosinophil peroxidase...

.... In this study we have established long-PCR banks of the mitochondrial genome from peripheral lymphocytes for an elderly cohort of 716 individuals with a range of measured aging phenotypes, and we have established assays for three widely reported mutations: the 4977 bp and 8048 bp deletions and point mutation...

... Biochemical Society 2003 immunity lipid kinase lymphocyte phenotype phosphoinositide Abbreviations used: BcR, B-cell receptor; Btk, Bruton's tyrosine kinase; GPCR, G-protein-coupled receptor; IBD, inflammatory bowel disease; IL, interleukin; PH, pleckstrin homology; PI3K, phosphoinositide...