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Keywords: lysosome
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Articles
Biochem Soc Trans (2022) 50 (6): 1773–1783.
Published: 09 December 2022
..., but rather mitochondria are engulfed directly by lysosomes, mediating mitochondrial secretion. As FNZ results in parkinsonism, we propose that excessive mitolysosome exocytosis is the cause. Correspondence: Xingguo Liu ( liu_xingguo@gibh.ac.cn ) 27 9 2022 14 11 2022 25 11 2022 ©...
Articles
Biochem Soc Trans (2018) 46 (2): 207–215.
Published: 22 February 2018
...Ana Serrano-Puebla; Patricia Boya Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the intracellular degradation of macromolecules. Damage of these organelles often results in lysosomal membrane permeabilization (LMP) and the release into the cytoplasm of the soluble...
Articles
Biochem Soc Trans (2016) 44 (2): 546–553.
Published: 11 April 2016
... ) and IP 3 receptor (IP 3 R) on the endoplasmic reticulum (ER). A less understood, parallel Ca 2+ signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca 2+ release from acidic Ca 2+ stores [e.g. endo-lysosomes, secretory vesicles...
Articles
Biochem Soc Trans (2016) 44 (1): 177–184.
Published: 09 February 2016
... lysosome neurodegeneration PIKfyve Vac14 Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. They regulate multiple pathways, including organization of the cytoskeleton, cellular motility, endocytosis and provide spatial and temporal...
Articles
Biochem Soc Trans (2015) 43 (3): 384–389.
Published: 01 June 2015
.... 1 To whom correspondence should be addressed (email Anthony.morgan@pharm.ox.ac.uk ) . 12 11 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 NAADP TPC Ca 2+ lysosome endosome Ca 2+ mobilization from intracellular stores is an ancient...
Articles
Biochem Soc Trans (2014) 42 (5): 1460–1464.
Published: 18 September 2014
...Ana M. Villamil Giraldo; Hanna Appelqvist; Thomas Ederth; Karin Öllinger Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes...
Articles
Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
... also allows them to direct Ca 2+ to specific intracellular targets that include other IP 3 Rs, mitochondria and Ca 2+ -regulated channels and enzymes. IP 3 Rs also interact functionally with lysosomes because Ca 2+ released by IP 3 Rs, but not that entering cells via store-operated Ca 2+ entry pathways...
Articles
Biochem Soc Trans (2013) 41 (6): 1495–1502.
Published: 20 November 2013
... disrupts lysosomal function and Ca 2+ homoeostasis, both of which are considered strong pathogenic factors in FAD. Loss of PS1 function compromises assembly and proton-pumping activity of the vacuolar-ATPase on lysosomes, leading to defective lysosomal acidification and marked impairment of autophagy...
Articles
Biochem Soc Trans (2013) 41 (6): 1509–1512.
Published: 20 November 2013
...Ryan P. McGlinchey; Jennifer C. Lee Mutations in the GBA1 gene, encoding the enzyme glucocerebrosidase, cause the lysosomal storage disorder GD (Gaucher’s disease), and are associated with the development of PD (Parkinson's disease) and other Lewy body disorders. Interestingly, GBA1 variants...
Articles
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
... proteins in lysosomes. 1 To whom correspondence should be addressed (email ana-maria.cuervo@einstein.yu.edu ). 2 7 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 aging autophagy chaperone lysosome neurodegeneration proteotoxicity Intracellular...
Articles
Biochem Soc Trans (2013) 41 (4): 951–955.
Published: 18 July 2013
... and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity. The heterodimeric Rag GTPases localize mTORC1 to lysosomes by their amino-acid-dependent interaction with the lysosomal Ragulator complex. Rheb is also thought to reside on lysosomes to activate mTORC1...
Articles
Biochem Soc Trans (2013) 41 (2): 475–490.
Published: 21 March 2013
... (email r.c.may@bham.ac.uk ). 4 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 intracellular survival lysosome macrophage pathogen phagocytosis phagosome Phagocytosis is arguably one of the most important processes in biology. From single-celled...
Articles
Biochem Soc Trans (2012) 40 (5): 1147–1151.
Published: 19 September 2012
... leucine-rich repeat kinase 2 (LRRK2) lysosome membrane Parkinson's disease LRRK2 is a ubiquitously expressed [ 1 ] member of the ROCO protein family [ 2 ]. It is composed of an active serine/threonine kinase domain with sequence similarities to the RIPKs (receptor-interacting protein kinases...
Articles
Biochem Soc Trans (2012) 40 (1): 153–157.
Published: 19 January 2012
...Sandip Patel; Eugen Brailoiu NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent Ca 2+ -mobilizing messenger implicated in many Ca 2+ -dependent cellular processes. It is highly unusual in that it appears to trigger Ca 2+ release from acidic organelles such as lysosomes. These signals...
Articles
Biochem Soc Trans (2011) 39 (5): 1533–1537.
Published: 21 September 2011
... similarities to the mammalian intrinsic pathway was conserved in yeast. Recently, lysosomes have also emerged as central players in mammalian apoptosis. Following LMP (lysosomal membrane permeabilization), lysosomal proteases such as cathepsins B, D and L are released into the cytosol and can trigger...
Articles
Biochem Soc Trans (2010) 38 (6): 1417–1419.
Published: 24 November 2010
...Paul R. Pryor; Sally A. Raines Lysosomes form part of our innate immunity and are an important line of defence against microbes, viruses and parasites. Although it is more than 50 years since de Duve discovered lysosomes, it is only in more recent years that we are slowly unravelling the molecular...
Articles
Biochem Soc Trans (2010) 38 (6): 1469–1473.
Published: 24 November 2010
... with lysosomes, leading to degradation of the internalized proteins. Four ESCRT complexes interact to concentrate cargo on the endosomal membrane, induce membrane curvature to form an intraluminal bud and finally pinch off the bud through a membrane-scission event to produce the intraluminal vesicle. Recent work...
Articles
Biochem Soc Trans (2010) 38 (6): 1479–1483.
Published: 24 November 2010
...Nikolaj H.T. Petersen; Thomas Kirkegaard Lysosomes, with their arsenal of catabolic enzymes and crucial metabolic housekeeping functions are experiencing a revived research interest after having lived a rather quiet life for the last few decades. With the discovery of the interaction...
Articles
Biochem Soc Trans (2010) 38 (6): 1413–1416.
Published: 24 November 2010
...J. Paul Luzio; Sally R. Gray; Nicholas A. Bright The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us...
Articles
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
...Paul Saftig; Bernd Schröder; Judith Blanz Whereas we have a profound understanding about the function and biogenesis of the protein constituents in the lumen of the lysosomal compartment, much less is known about the functions of proteins of the lysosomal membrane. Proteomic analyses...
Articles
Biochem Soc Trans (2010) 38 (6): 1424–1431.
Published: 24 November 2010
... the endoplasmic reticulum, the major site of action of the other two principal Ca 2+ -mobilizing messengers, Ins P 3 and cADPR (cADP-ribose). Studies of the messenger roles of NAADP and the function of TPCs highlight the novel role of lysosomes and other organelles of the endocytic pathway as messenger-regulated...
Articles
Biochem Soc Trans (2009) 37 (5): 1019–1021.
Published: 21 September 2009
...J. Paul Luzio; Michael D.J. Parkinson; Sally R. Gray; Nicholas A. Bright In mammalian cells, endocytosed cargo that is internalized through clathrin-coated pits/vesicles passes through early endosomes and then to late endosomes, before delivery to lysosomes for degradation by proteases. Late...
Articles
Biochem Soc Trans (2009) 37 (1): 178–180.
Published: 20 January 2009
... vesicles of MVBs (multivesicular bodies). We have focussed on studying the ESCRT requirements for delivery of MHC class I to lysosomes following polyubiquitination by the Kaposi's sarcoma-associated herpesvirus protein K3. Down-regulation of polyubiquitinated cell-surface MHC class I in HeLa cells stably...
Articles
Biochem Soc Trans (2009) 37 (1): 151–155.
Published: 20 January 2009
..., cytoskeletal remodelling, protein folding and proteolysis. The AAA Vps (vacuolar protein sorting) 4 is central to traffic to lysosomes, retroviral budding and mammalian cell division. It dissociates ESCRTs (endosomal sorting complexes required for transport) from endosomal membranes, enabling their recycling...
Articles
Biochem Soc Trans (2007) 35 (5): 1088–1091.
Published: 25 October 2007
...J.P. Luzio; N.A. Bright; P.R. Pryor The passage of endocytosed receptor-bound ligands and membrane proteins through the endocytic pathway of mammalian cells to lysosomes occurs via early and late endosomes. The latter contain many luminal vesicles and are often referred to as MVBs (multivesicular...
Articles
Biochem Soc Trans (2007) 35 (2): 343–348.
Published: 20 March 2007
... were observed. 1 To whom correspondence should be addressed (email enzo.agostinelli@uniroma1.it ). 25 10 2006 © 2007 The Biochemical Society 2007 hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell The cytotoxicity of BSAO (bovine serum...
Articles
Biochem Soc Trans (2006) 34 (5): 922–926.
Published: 25 October 2006
... model for NAADP-induced Ca 2+ signalling is presented. 1 email antony.galione@pharm.ox.ac.uk 3 8 2006 © 2006 The Biochemical Society 2006 bafilomycin Ca 2+ store endoplasmic reticulum inositol 1,4,5-trisphosphate (IP 3 ) lysosome nicotinic acid–adenine dinucleotide...
Articles
Biochem Soc Trans (2006) 34 (3): 340–342.
Published: 22 May 2006
... endoplasmic reticulum membrane contact site lysosome nuclear envelope nucleus–vacuole junction yeast The ER (endoplasmic reticulum) is closely associated with a number of functionally distinct organelles, including mitochondria, Golgi, peroxisomes, vacuoles/lysosomes and the plasma membrane...
Articles
Biochem Soc Trans (2001) 29 (4): 488–493.
Published: 01 August 2001
... that a GHR truncated at residue 369 can enter the cells in the presence of a proteasome inhibitor, but that the subsequent lysosomal degradation of GH is blocked. Lysosomal inhibitors prolong the half-life of both receptor and ligand. Experiments with antibodies against different receptor tail sections show...