... cell proliferation mRNA degradation yeast In eukaryotes, cytoplasmic mRNA decay is initiated by removal of the poly(A) tail. This first step in the turnover pathway is unique in that it is reversible and some transcripts can be readenylated and returned to polysomes. CCR4 (CC chemokine...

... 2010 Biochemical Society 2010 endonuclease mRNA degradation nonsense-mediated mRNA decay premature translation-termination codon (PTC) The cascade of events during gene expression involves a series of complex and tightly linked steps from transcription of the DNA-encoded genetic...

..., as mRNAs can also exit P-bodies and re-initiate translation [ 16 , 17 ]. A second class of mRNAs linked to P-bodies contain AREs in their 3′-UTRs (untranslated regions). AREs are found in many cytokine and proto-oncogene mRNAs, and by mediating rapid mRNA degradation they potently inhibit gene...

... that cells undergo in response to iron deficit and the regulatory mechanisms that allow these adaptive responses. In the present article, we summarize recent work on genome-wide metabolic reprogramming in response to iron deficiency, mediated by specific mRNA degradation mechanisms that allow S. cerevisiae...

... sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation Cell 1986 46 659 667 6 Chen C.-Y.A. Shyu A.-B. AU-rich elements: characterization and importance in mRNA degradation Trends Biochem. Sci. 1995 20 465 470 7 Bakheet T...

... the exosome and a 5′–3′-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation...

.... This article reviews the pathways and enzymes that control mRNA turnover in eukaryotic cells and discusses their mechanisms of control. © 2006 The Biochemical Society 2006 gene expression mRNA turnover mRNA degradation post-transcriptional control ribonuclease The development of a single...