...-canonical reader. These proteins play a crucial role in determining RNA stability: YTHDFs mainly promote mRNA degradation through different cytoplasmic pathways, whereas IGF2BPs function to maintain mRNA stability. Additionally, YTHDC1 functions within the nucleus to degrade or protect certain m 6...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . embryogenesis mRNA mRNA stability oogenesis translation Immediately after fertilization, embryos rely on components of maternal origin for development. In metazoans, transcription stops...

.... In this review, we discuss the links between translation and mRNA stability, with an emphasis on emerging data suggesting that codon optimality may regulate mRNA degradation. In addition to its role in quality control, NMD regulates the expression of hundreds of normal transcripts that mimic the aberrant...

... 2 (MK2), regulating target genes at a post-transcriptional level, inhibiting deadenylation, increasing mRNA stability and/or increasing its translational efficiency [ 41 ]. Tight regulation of MAPK p38 signalling is critical to prevent ectopic, excessive or unprovoked inflammation. An important...

... ) 19 4 2016 23 5 2016 26 5 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 DIS3L2 human disease mRNA stability RNA degradation virus–host interactions XRN1 Ribonucleases are key enzymes involved in the control...

...Christopher Tiedje; Alexey Kotlyarov; Matthias Gaestel TTP (tristetraprolin) is an RNA-binding protein which regulates mRNA stability or translation or both. The molecular mechanisms which are responsible and which discriminate between regulation of mRNA stability and translation are not completely...

... uncharacterized mechanisms of zinc-regulated transcription in mammalian cells. In addition, recent findings reveal a role for effects of zinc on mRNA stability in the regulation of specific zinc transporters. Our studies on the regulation of the human gene SLC30A5 (solute carrier 30A5), which codes for the zinc...

... that may be involved in that process. 1 To whom correspondence should be addressed (email [email protected] ). 22 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase...

... is induced rapidly and transiently in response to a plethora of stimuli; (ii) COX - 2 mRNA stability and translational efficiency is governed by multiple regulatory elements within the 3′-untranslated region; (iii) specific microRNAs and RNA-binding proteins influence COX - 2 mRNA stability; and (iv...

... regulation methionine biosynthesis mRNA stability nascent polypeptide S -adenosylmethionine 1 Present address: Center for Plant Molecular Genetics and Breeding Research, Seoul National University, Seoul 151-742, South Korea. 2 Present address: Delaware Biotechnology Institute...