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Keywords: mRNA translation
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Biochem Soc Trans (2024) 52 (1): 481–490.
Published: 22 February 2024
... Commons Attribution License 4.0 (CC BY-NC-ND) . Coronaviruses COVID-19 mRNA translation Nsp1 SARS-CoV-2 viral infection In recent years, the emergence of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, has drawn significant attention to the intricate interactions...
Biochem Soc Trans (2020) 48 (6): 2565–2578.
Published: 27 November 2020
... in their function: modulating their composition, size, density, and the network-like architecture in relation to the metabolic demands of the cell. Here, we review the recent research on the post-transcriptional regulation of mitochondrial composition focusing on mRNA localization, mRNA translation, protein import...
Biochem Soc Trans (2017) 45 (2): 353–364.
Published: 13 April 2017
...Laura Hidalgo; Chad M. Swanson Human immunodeficiency virus type 1 (HIV-1) mRNA translation is a complex process that uses the host translation machinery to synthesise viral proteins. Several mechanisms for HIV-1 mRNA translation initiation have been proposed including (1) cap-dependent, eIF4E...
Biochem Soc Trans (2017) 45 (1): 213–221.
Published: 15 February 2017
... growth mRNA translation mTORC1 mTOR TOP motif Over the last several decades, a series of potential TOP regulators have been proposed. Among the most recent candidates are the T-cell intracellular antigen 1 (TIA1) and TIA1-related (TIAR) RNA-binding proteins. These translation repressors...
Biochem Soc Trans (2015) 43 (3): 328–332.
Published: 01 June 2015
..., the stage in mRNA translation that consumes almost all the energy and amino acids consumed by protein synthesis. In addition to activation by Ca/CaM, eEF2K is also regulated by an array of other regulatory inputs, which include inhibition by the nutrient- and growth-factor activated signalling pathways...
Biochem Soc Trans (2014) 42 (4): 1229–1237.
Published: 11 August 2014
... Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. development gametogenesis mRNA stability and mRNA localization mRNA translation neuron poly(A)-binding...
Biochem Soc Trans (2013) 41 (4): 923–926.
Published: 18 July 2013
... signalling to drive cell growth and proliferation. 1 email C.G.Proud@soton.ac.uk 20 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 eukaryotic elongation factor 2 (eEF2) mammalian target of rapamycin complex 1 (mTORC1) mRNA translation ribosome...
Biochem Soc Trans (2010) 38 (6): 1598–1601.
Published: 24 November 2010
... the transcription of protein-encoding mRNAs and the tRNAs and rRNA which mediate mRNA translation into protein. Myc proteins also up-regulate translation by increasing addition of the 7-methylguanosine cap (methyl cap) to the 5′ end of pre-mRNA. Addition of the methyl cap increases the rate at which transcripts...
Biochem Soc Trans (2008) 36 (3): 528–530.
Published: 21 May 2008
... in cancers of these tissues. Musashi has been primarily implicated as a repressor of target mRNAs in stem cell populations. However, little is known about the mechanism by which Musashi exerts mRNA translational control or how Musashi function is regulated. Recent findings in oocytes of the frog, Xenopus...
Biochem Soc Trans (2006) 34 (2): 213–216.
Published: 20 March 2006
... synthesis and mRNA translation. Since eIF2B is required for all translation initiation events, this mechanism promotes overall protein synthesis. Conversely, eIF2B is activated by insulin [ 4 ]. This involves a change in the phosphorylation of its largest ϵ-subunit, which contains the catalytic domain...
Biochem Soc Trans (2001) 29 (4): 541–547.
Published: 01 August 2001
... Society 2001 amino acids glucose initiation factor mRNA translation protein synthesis AMP-k, AMP-activated protein kinase CHO, Chinese hamster ovary D-PBS, Dulbecco's phosphate-buffered saline eEF, eukaryotic elongation factor eEF2k, eEF2 kinase elF, eukaryotic initiation factor 4E...