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Keywords: macrophage
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Articles
Biochem Soc Trans (2018) 46 (3): 631–639.
Published: 09 May 2018
... phosphatidylserine (PS) is well established on apoptotic cells [ 43 , 44 ] and EV. Given the immune-modulating role of PS on AC (promoting AC uptake [ 45 , 46 ] and driving TGF-β1 and IL-10 production from macrophages [ 47 , 48 ]), it seems likely that this exposed PS will also be an active component of ACdEV...
Articles
Biochem Soc Trans (2015) 43 (4): 740–744.
Published: 03 August 2015
...Lisardo Boscá; Silvia González-Ramos; Patricia Prieto; María Fernández-Velasco; Marina Mojena; Paloma Martín-Sanz; Susana Alemany Macrophages are present in a large variety of locations, playing distinct functions that are determined by its developmental origin and by the nature of the activators...
Articles
Biochem Soc Trans (2014) 42 (2): 244–249.
Published: 20 March 2014
... context are several observations that TGR5 signalling curbs the inflammatory response of macrophages via interfering with NF-κB (nuclear factor κB) activity. In line with this, recent animal studies also suggest that TGR5 could be exploited as a potential target for intervention in a number of...
Articles
Biochem Soc Trans (2013) 41 (4): 927–933.
Published: 18 July 2013
... remodelling and wound healing. Myeloid phagocytes such as monocytes, macrophages or dendritic cells are at the basis of controlling these immune responses in all tissues of the body. In the present review, we summarize recent studies demonstrating that mTOR [mammalian (or mechanistic) target of rapamycin...
Articles
Biochem Soc Trans (2013) 41 (2): 475–490.
Published: 21 March 2013
... groups of pathogens have evolved mechanisms to avoid killing by phagocytic cells. The present review discusses a key innate immune cell, the macrophage, and highlights the myriad mechanisms microbes have established to escape phagocytic killing. 1 To whom correspondence should be addressed...
Articles
Biochem Soc Trans (2013) 41 (1): 268–272.
Published: 29 January 2013
...-kr.edu.pl ). 21 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 macrophage microvesicle monocyte tumour Questions concerning interactions of tumour cells with monocytes are currently a subject of many major studies. Monocytes and macrophages derived...
Articles
Biochem Soc Trans (2011) 39 (5): 1166–1168.
Published: 21 September 2011
... differentiation, whereas Myo9b has been shown to play an important role in the regulation of macrophage shape and motility. 1 To whom correspondence should be addressed (email baehler@uni-muenster.de ). 7 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell...
Articles
Biochem Soc Trans (2011) 39 (5): 1288–1292.
Published: 21 September 2011
... 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 electrochemical detection isolated mitochondrion macrophage optical nanosensor reactive oxygen species (ROS) superoxide dismutase (SOD) ROS (reactive oxygen species) such as superoxide (O 2 – ) play a...
Articles
Biochem Soc Trans (2009) 37 (1): 185–189.
Published: 20 January 2009
... subsequent assembly and release of infectious virus particles, is co-coordinated through interactions between the viral structural proteins and cellular proteins. In the present paper, we consider how these events occur during HIV production in macrophages. In these cells, virus assembly appears to occur on...
Articles
Biochem Soc Trans (2008) 36 (3): 340–342.
Published: 21 May 2008
.... Indeed, analysis of β-cells from patients with Type 2 diabetes displays increased IL-1β (interleukin 1β) expression. Furthermore, increased islet-associated macrophages are observed in human Type 2 diabetic patients and in most animal models of diabetes. Importantly, increased numbers of macrophages are...
Articles
Biochem Soc Trans (2007) 35 (6): 1453–1455.
Published: 23 November 2007
.../macrophages and dendritic cells. TLR2-mediated cell activation in response to endogenous and exogenous agents is proatherogenic in hyperlipidaemic mice. 1 To whom correspondence should be addressed (email lcurtiss@scripps.edu ). 1 8 2007 © The Authors Journal compilation © 2007...
Articles
Biochem Soc Trans (2007) 35 (3): 437–439.
Published: 22 May 2007
... which have shown that CMRs influence vascular function via interactions with cells of the artery wall, including endothelial cells and macrophages, and also highlighted the part played by CMRs in the development of premature atherosclerosis in conditions such as the metabolic syndrome, which are an...
Articles
Biochem Soc Trans (2007) 35 (2): 284–287.
Published: 20 March 2007
... have both direct and indirect effects on macrophage function. This mini-review highlights a mechanism through which oxidative stress via the production of reactive carbonyls alters the ECM (extracellular matrix) environment of macrophages, thereby altering their behaviour. Carbonyl modification of ECM...
Articles
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
...G. Chinetti; J.C. Fruchart; B. Staels PPARs (peroxisome-proliferator-activated receptors) and LXRs (liver X receptors) are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Since the macrophage plays an important role in host...
Articles
Biochem Soc Trans (2006) 34 (6): 1028–1031.
Published: 25 October 2006
... 2006 © 2006 The Biochemical Society 2006 immune response inflammation interleukin-10 (IL-10) macrophage sepsis signal transducer and activator of transcription 3 (STAT3) Both the adaptive and innate arms of the mammalian immune response have developed multiple extrinsic and...
Articles
Biochem Soc Trans (2005) 33 (1): 198–199.
Published: 01 February 2005
...P.C. Mills; D.J. Richardson; J.C.D. Hinton; S. Spiro Salmonella possesses multiple enzymes that utilize NO as a substrate, and could therefore contribute to the organism's ability to resist nitrosative killing by macrophages. Flavorubredoxin is an oxygen-sensitive enzyme that reduces NO to nitrous...
Articles
Biochem Soc Trans (2004) 32 (3): 496–498.
Published: 01 June 2004
...I.P. Fairbairn Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis . A greater understanding of these observations will lead to new...
Articles
Biochem Soc Trans (2004) 32 (1): 134–138.
Published: 01 February 2004
... pro-atherogenic properties of in vitro oxidized lipoproteins, such as stimulation of chemotaxis and sterol accumulation in macrophages, adhesion molecule expression on endothelial cells and apoptosis of several cell types. It was supported by detection of oxidation products in lesion lipoproteins...
Articles
Biochem Soc Trans (2002) 30 (4): 774–777.
Published: 01 August 2002
...H. Bowen; T. E. Biggs; S. T. Baker; E. Phillips; V. H. Perry; D. A. Mann; C. H. Barton The Nrampl (natural resistance-associated macrophage protein 1) gene modulates the growth of intracellular pathogens and encodes a divalent cation transporter within lysosomes/late endosomes of macrophages...
Articles
Biochem Soc Trans (2002) 30 (2): 98–102.
Published: 01 April 2002
... matrix metalloproteinases are expressed in association with COPD in humans. Application of genetargeted macrophage elastase and neutrophil elastase to a mouse model of cigarette-smoke-induced emphysema has uncovered roles for these proteinases in airspace enlargement, and has identified many interactions...
Articles
Biochem Soc Trans (2001) 29 (6): 853–859.
Published: 01 November 2001
... immune system. 1 e-mail bruce@scripps.edu 13 7 2001 © 2001 Biochemical Society 2001 endotoxin infection innate immunity lipopoly-saccharide macrophage Toll-like receptors IL, interleukin LPS, lipopolysaccharide TLR, Toll-like receptor TNF, tumour necrosis factor...