... influenza macrophage necroptosis pyroptosis Correspondence: Larisa I. Labzin ( [email protected] ) 1 11 2022 13 1 2023 16 1 2023 © 2023 The Author(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...

... of developing plaques and, despite recruitment of monocytes and macrophages to clear dying cells, the inflammation fails to resolve and progresses [ 4 , 5 ]. In this case, monocyte recruitment is a driving disease as, once recruited, the monocytes are exposed to the toxic environment and, importantly, become...

...Lisardo Boscá; Silvia González-Ramos; Patricia Prieto; María Fernández-Velasco; Marina Mojena; Paloma Martín-Sanz; Susana Alemany Macrophages are present in a large variety of locations, playing distinct functions that are determined by its developmental origin and by the nature of the activators...

... in this context are several observations that TGR5 signalling curbs the inflammatory response of macrophages via interfering with NF-κB (nuclear factor κB) activity. In line with this, recent animal studies also suggest that TGR5 could be exploited as a potential target for intervention in a number...

... remodelling and wound healing. Myeloid phagocytes such as monocytes, macrophages or dendritic cells are at the basis of controlling these immune responses in all tissues of the body. In the present review, we summarize recent studies demonstrating that mTOR [mammalian (or mechanistic) target of rapamycin...

... groups of pathogens have evolved mechanisms to avoid killing by phagocytic cells. The present review discusses a key innate immune cell, the macrophage, and highlights the myriad mechanisms microbes have established to escape phagocytic killing. 4 2 2013 © The Authors Journal compilation ©...

...-kr.edu.pl ). 21 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 macrophage microvesicle monocyte tumour Questions concerning interactions of tumour cells with monocytes are currently a subject of many major studies. Monocytes and macrophages derived...

... and differentiation, whereas Myo9b has been shown to play an important role in the regulation of macrophage shape and motility. 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2011 Biochemical Society 2011 cell migration epithelium...

... a porous, bio-inert polyacrylamide nanostructure, enabling passive monitoring of free radical flux within the intracellular environment. Alexa Fluor® 568 (λ ex 578 nm and λ em 603 nm) was used as the non-responsive reference dye. Successful delivery of the nanosensors into NR8383 rat alveolar macrophage...

..., and the subsequent assembly and release of infectious virus particles, is co-coordinated through interactions between the viral structural proteins and cellular proteins. In the present paper, we consider how these events occur during HIV production in macrophages. In these cells, virus assembly appears to occur...

.... Indeed, analysis of β-cells from patients with Type 2 diabetes displays increased IL-1β (interleukin 1β) expression. Furthermore, increased islet-associated macrophages are observed in human Type 2 diabetic patients and in most animal models of diabetes. Importantly, increased numbers of macrophages...

.../macrophages and dendritic cells. TLR2-mediated cell activation in response to endogenous and exogenous agents is proatherogenic in hyperlipidaemic mice. 1 To whom correspondence should be addressed (email [email protected] ). 1 8 2007 © The Authors Journal compilation © 2007...

... which have shown that CMRs influence vascular function via interactions with cells of the artery wall, including endothelial cells and macrophages, and also highlighted the part played by CMRs in the development of premature atherosclerosis in conditions such as the metabolic syndrome, which...

... have both direct and indirect effects on macrophage function. This mini-review highlights a mechanism through which oxidative stress via the production of reactive carbonyls alters the ECM (extracellular matrix) environment of macrophages, thereby altering their behaviour. Carbonyl modification of ECM...

...G. Chinetti; J.C. Fruchart; B. Staels PPARs (peroxisome-proliferator-activated receptors) and LXRs (liver X receptors) are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Since the macrophage plays an important role in host...

... lineage cells and is most robustly expressed in macrophages and dendritic cells, accounting for the cell-specific effects of IL-10 [ 17 ]. The IL-10R is composed of two chains: the IL-10Rα chain that is responsible for docking STAT3 and the IL-10Rβ chain that is a shared subunit with other members...

...P.C. Mills; D.J. Richardson; J.C.D. Hinton; S. Spiro Salmonella possesses multiple enzymes that utilize NO as a substrate, and could therefore contribute to the organism's ability to resist nitrosative killing by macrophages. Flavorubredoxin is an oxygen-sensitive enzyme that reduces NO to nitrous...

...I.P. Fairbairn Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis . A greater understanding of these observations will lead to new...

... by the pro-atherogenic properties of in vitro oxidized lipoproteins, such as stimulation of chemotaxis and sterol accumulation in macrophages, adhesion molecule expression on endothelial cells and apoptosis of several cell types. It was supported by detection of oxidation products in lesion lipoproteins...

...H. Bowen; T. E. Biggs; S. T. Baker; E. Phillips; V. H. Perry; D. A. Mann; C. H. Barton The Nrampl (natural resistance-associated macrophage protein 1) gene modulates the growth of intracellular pathogens and encodes a divalent cation transporter within lysosomes/late endosomes of macrophages...

... and matrix metalloproteinases are expressed in association with COPD in humans. Application of genetargeted macrophage elastase and neutrophil elastase to a mouse model of cigarette-smoke-induced emphysema has uncovered roles for these proteinases in airspace enlargement, and has identified many interactions...

.... 1 e-mail [email protected] 13 7 2001 © 2001 Biochemical Society 2001 endotoxin infection innate immunity lipopoly-saccharide macrophage Toll-like receptors IL, interleukin LPS, lipopolysaccharide TLR, Toll-like receptor TNF, tumour necrosis factor Signal...