...Prasida Holla; Jyoti Bhardwaj; Tuan M. Tran Despite having the highest risk of progressing to severe disease due to lack of acquired immunity, the youngest children living in areas of highly intense malaria transmission have long been observed to be infected at lower rates than older children...

...Claire Dunican; Clare Andradi-Brown; Stefan Ebmeier; Athina Georgiadou; Aubrey J. Cunnington The blood transcriptome of malaria patients has been used extensively to elucidate the pathophysiological mechanisms and host immune responses to disease, identify candidate diagnostic and prognostic...

...Takahiro Ishizaki; Sophia Hernandez; Martina S. Paoletta; Theo Sanderson; Ellen S.C. Bushell The ∼30 Mb genomes of the Plasmodium parasites that cause malaria each encode ∼5000 genes, but the functions of the majority remain unknown. This is due to a paucity of functional annotation from sequence...

...Petar P. S. Calic; Mahta Mansouri; Peter J. Scammells; Sheena McGowan Malaria continues to be a global health threat, affecting approximately 219 million people in 2018 alone. The recurrent development of resistance to existing antimalarials means that the design of new drug candidates must...

... ) or Davide M. Ferraris ( [email protected] ) 16 12 2019 10 3 2020 16 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer drug discovery and design malaria NAD biology NAD dehydrogenases tuberculosis...

...Marco Biddau; Lilach Sheiner Malaria continues to be one of the leading causes of human mortality in the world, and the therapies available are insufficient for eradication. Severe malaria is caused by the apicomplexan parasite Plasmodium falciparum . Apicomplexan parasites, including...

... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antibiotics infection malaria proteoglycan Glycans represent one of the most diverse classes of biological macromolecules. They are a major part of the biomass of every organism...

... including mediating replication of a number of pathogenic RNA viruses, and in the development of the parasite responsible for malaria. Key to the regulation of PI4Ks is their regulation by a variety of both host and viral protein-binding partners. We review herein our current understanding of the structure...

... simulate effects of drug-induced inhibition of reaction steps on the whole-body physiology. We illustrate the approach for glucose metabolism in malaria patients, by merging two detailed kinetic models for glucose metabolism in the parasite Plasmodium falciparum and the human red blood cell with a coarse...

...Kevin J. Saliba; Christina Spry Malaria kills more than half a million people each year. There is no vaccine, and recent reports suggest that resistance is developing to the antimalarial regimes currently recommended by the World Health Organization. New drugs are therefore needed to ensure malaria...

... of 10% serum. Recent studies have reported plasma stable pantothenamides that were active against the malaria parasite Plasmodium falciparum . We conclude that VNN inhibitors and pantothenate derivatives that target enzymes in the CoA (coenzyme A) biosynthetic pathway may have potential use as novel...

...Bertrand Arnou; Cédric Montigny; Jens Preben Morth; Poul Nissen; Christine Jaxel; Jesper V. Møller; Marc le Maire The disease malaria, caused by the parasite Plasmodium falciparum , remains one of the most important causes of morbidity and mortality in sub-Saharan Africa. In the absence...

...Ming Kalanon; Geoffrey I. McFadden Malaria, which is caused by species of the parasite genus Plasmodium , remains a major global health problem. A vestigial plastid homologous with the chloroplasts of plants and algae was discovered in malaria and related parasites from the phylum Apicomplexa...

...Srabasti J. Chakravorty; Katie R. Hughes; Alister G. Craig Cytoadherence of PRBCs ( Plasmodium falciparum -infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive...

...S. Günther; P.J. McMillan; L.J.M. Wallace; S. Müller The human malaria parasite Plasmodium falciparum possesses a single mitochondrion and a plastid-like organelle called the apicoplast. Both organelles contain members of the KADH (α-keto acid dehydrogenase) complexes – multienzyme complexes...

... tuberculosis and Helicobacter pylori . The pathway is also essential in the malaria vector Plasmodium falciparum . During the last few years, the genes, enzymes, intermediates and mechanisms of the biosynthetic route have been elucidated by a combination of comparative genomics, enzymology, advanced NMR...

... sleeping sickness, Chagas' disease, leishmaniasis and malaria. These enzymes exhibit features that differ significantly between the parasites and the human host. Therefore it is conceivable that exploitation of such differences can lead to the design of new inhibitors that will selectively kill...