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Keywords: mass spectrometry
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2025) 53 (01): 303–314.
Published: 12 February 2025
...-throughput studies characterizing brain PPIs, using affinity purification, proximity labeling, co-fractionation, and chemical cross-linking mass spectrometry methods, as well as yeast two-hybrid assays. We present the current state of the field, discuss challenges, and highlight promising future directions...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2439–2453.
Published: 10 December 2024
...Siyuan Kong; Wei Zhang; Weiqian Cao Recent advances in mass spectrometry (MS)-based methods have significantly expanded the capabilities for quantitative glycoproteomics, enabling highly sensitive and accurate quantitation of glycosylation at intact glycopeptide level. These developments have...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 627–637.
Published: 04 April 2024
... of this ubiquitination modification. Despite many biochemical or proteomic approaches available for ubiquitination detection, mass-spectrometry stood out to be the most efficient and transformative technology to read this complex modification script. Here in this review, we have discussed how different ubiquitin codes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1569–1582.
Published: 01 December 2022
... that linoleic acid (LA) and α-linolenic acid (ALA), possessing unsaturations on the ω-6 and ω-3 carbon, respectively, are essential fatty acids that cannot be produced by mammalian enzymatic systems ( Figure 1 ) [ 10 ]. bioactive lipid linoleic acid lipid mediators mass spectrometry octadecanoid...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1057–1067.
Published: 13 June 2022
... for the analytical tools used to investigate these systems of increased size and complexity, such as Native Mass Spectrometry, which has always been an important tool for structural biology. Scientific advance and recent developments, such as new ways to mimic a cell membrane for a membrane protein, have caused...
Articles
Thomas Peters, Robert Creutznacher, Thorben Maass, Alvaro Mallagaray, Patrick Ogrissek, Stefan Taube, Lars Thiede, Charlotte Uetrecht
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 347–359.
Published: 23 December 2021
... structures of VP1 protruding domain dimers, so called P-dimers, complexed with different HBGAs have been solved to atomic resolution. Corresponding binding affinities have been determined for HBGAs and other glycans exploiting different biophysical techniques, with mass spectrometry (MS) and nuclear magnetic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
... interactors. Recent advances in mapping direct interactors of histone PTMs as well as local chromatin interactomes will be highlighted, with a focus on mass-spectrometry based workflows that continue to illuminate histone-mediated PPIs in unprecedented detail. Much of our knowledge of the hPTM landscape has...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1643–1662.
Published: 20 July 2021
...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. glycobiology glycomics glycoproteomics mass spectrometry multi-omics proteomics Protein post-translational modifications (PTMs) enable the cell to produce...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1241–1250.
Published: 07 May 2021
... have been characterised in detail by a range of mass spectrometry techniques, including direct infusion and liquid chromatography mass spectrometry, there are relatively few reports of comprehensive analyses of oxidised phospholipids in disease states. Oxidised phospholipid species are widely thought...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 55–69.
Published: 25 January 2021
...Kay-Hooi Khoo The nature of protein glycosylation renders cellular glycomics a very challenging task in having to deal with all the disparate glycans carried on membrane glycoproteins. Rapid mapping by mass spectrometry analysis provides only a coarse sketch of the glycomic complexity based...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 161–186.
Published: 13 January 2021
...Anastasia Chernykh; Rebeca Kawahara; Morten Thaysen-Andersen Facilitated by advances in the separation sciences, mass spectrometry and informatics, glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling new insights into the complex glycoproteome. While...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
...Charles Eldrid; Konstantinos Thalassinos Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1953–1966.
Published: 20 October 2020
...Lindsay K. Pino; Jacob Rose; Amy O'Broin; Samah Shah; Birgit Schilling Research into the basic biology of human health and disease, as well as translational human research and clinical applications, all benefit from the growing accessibility and versatility of mass spectrometry (MS)-based...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 945–954.
Published: 15 May 2020
...Lisa M. Jones Mass spectrometry (MS) has long been used to study proteins mainly via sequence identification and quantitation of expression abundance. In recent years, MS has emerged as a tool for structural biology. Intact protein structural analysis has been enabled by the development of methods...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 317–326.
Published: 03 February 2020
... analysis, desorption electrospray ionisation and nanospray desorption electrospray ionisation. Similarly, developments in native mass spectrometry allow protein–protein and protein–ligand complexes to be ionised and analysed. Identification and characterisation of these large ions involves a suite...
Articles
In Collection
Protein structure and function
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
...Timothy M. Allison; Cherine Bechara Mass spectrometry (MS) provides an impressive array of information about the structure, function and interactions of proteins. In recent years, many new developments have been in the field of native MS and these exemplify a new coming of age of this field...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
..., autoimmunity and neurodegeneration, demonstrating the importance of ubiquitylation. Therefore, enzymes of the ubiquitin system are considered highly attractive drug targets. In recent years, mass spectrometry (MS)-based techniques have become increasingly important in the deciphering of the ubiquitin system...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 251–260.
Published: 15 February 2017
... and models derived from mass spectrometry (MS) datasets were correct. With recent advances in structure determination, many of the most challenging complexes that we studied over the years have become tractable by other structural biology approaches enabling such comparisons to be made. Moreover...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 983–994.
Published: 09 October 2015
... with mass spectrometry (MS) (XF–MS), which provide residue-specific information on the solvent accessibility of proteins. In combination with both low- and high-resolution data from other structural biology approaches, it is capable of providing valuable insights into dynamics of membrane proteins, which...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1698–1703.
Published: 17 November 2014
... will require novel analytical and quantitative approaches. References 1 Jeffery C.J. Moonlighting proteins Trends Biochem. Sci. 1999 24 8 11 10.1016/S0968-0004(98)01335-8 10087914 2 Jeffery C.J. Mass spectrometry and the search for moonlighting proteins Mass Spectrom. Rev...
Articles
Robert J. Beynon, Stuart D. Armstrong, Guadalupe Gómez-Baena, Victoria Lee, Deborah Simpson, Jennifer Unsworth, Jane L. Hurst
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 837–845.
Published: 11 August 2014
... caused by the stable isotope labelling. Stable-isotope-labelled peptides are also known as AQUA peptides [ 28 – 30 ]. © The Authors Journal compilation © 2014 Biochemical Society 2014 major urinary protein (MUP) mass spectrometry stable isotope QconCAT The polymorphic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1107–1111.
Published: 11 August 2014
... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 coenzyme A enzymatic assay HPLC mass spectrometry unesterified coenzyme A (CoASH) Since the discovery of CoA (coenzyme A) by Fritz Lipmann over 60 years ago, various methods have been developed to isolate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 791–797.
Published: 11 August 2014
... for Activiomics Ltd. 2 To whom correspondence should be addressed (email [email protected] ). 21 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 acquired resistance cancer mass spectrometry phosphoproteomics signalling plasticity systems biology...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
...) are quantified using 25 μg of protein, 10 μg of DNA or 5 μl of physiological fluid. Protein and nucleotide AGE (advanced glycation end-product) assay protocols resistant to interferences is described. dicarbonyl stress glycation mass spectrometry methylglyoxal 3-nitrotyrosine oxidative stress 8...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 450–456.
Published: 20 March 2014
... (AGE) diabetic complication glycaemic fluctuation mass spectrometry metformin methylglyoxal The present review discusses three areas where studies of AGEs (advanced glycation end-products) and their precursors have helped to shed light on important diagnostic and therapeutic areas relating...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 145–150.
Published: 23 January 2014
... spectrometry (HDX-MS) mass spectrometry protein dynamics protein kinase Kinase domains have an inherent flexibility that allows them to transition between activation states in a highly regulated manner. The MAPK (mitogen-activated protein kinase) ERK2 (extracellular-signal-regulated kinase 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 1089–1095.
Published: 18 July 2013
... A. Jensen O.N. Peck S.C. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry Mol. Cell. Proteomics 2003 2 1234 1243 50 Reinders J. Sickmann A. State-of-the-art in phosphoproteomics Proteomics...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1233–1239.
Published: 21 September 2011
... [email protected] ). 24 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 chlorinated phospholipid inflammation mass spectrometry oxidized phospholipid (oxPL) precursor ion scanning Toll-like receptor (TLR) DNPH 2,4-dinitrophenylhydrazine ER...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1217–1220.
Published: 21 September 2011
... area. 1 To whom correspondence should be addressed (email [email protected] ). 19 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 biomolecular damage cell signalling fluorescence free radical mass spectrometry measurement The present...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1348–1352.
Published: 21 September 2011
[email protected] ). 29 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 mass spectrometry proteomics systems biology traditional Chinese medicine two-dimensional protein electrophoresis In conclusion, application of proteomics in TCM studies is still...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1240–1246.
Published: 21 September 2011
... lipoxygenase (LOX) mass spectrometry polyunsaturated fatty acid (PUFA) PUFAs (polyunsaturated fatty acids) are important bioactive nutrients that exert a plethora of biological effects through their ability to alter the composition of cellular membranes, activate gene transcription and signalling...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1334–1340.
Published: 21 September 2011
... Society 2011 congenital disorder of glycosylation congenital neutropenia glycogen storage disease 1b (GSD 1b) mass spectrometry matrix-assisted laser-desorption ionization–time-of-flight (MALDI–TOF) N-glycan Glycans attached to proteins and lipids on the surfaces of immune cells serve...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1260–1267.
Published: 21 September 2011
... dibromobimane (DBB) glutaredoxin (Grx) mass spectrometry thiol oxidation thioredoxin (Trx) Cellular proteins can undergo a diverse array of post-translational modifications that include the addition of lipids, phosphate, sugars and oxidant moieties. Specific modifications can occur preferentially...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1307–1313.
Published: 24 September 2010
... that decorate many of these sugars. 14 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 bacterium flagellin glycoproteomics glycosylation mass spectrometry pilin Similar to the aforementioned Ps. aeruginosa strains, the plant pathogen Ps. syringae has...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 883–887.
Published: 26 July 2010
... Journal compilation © 2010 Biochemical Society 2010 interaction proteomics mass spectrometry protein complex tandem affinity purification More than the proteins themselves, multimeric protein complexes constitute the fundamental and functional units of the proteome [ 1 , 2 ]. Indeed, most...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 905–909.
Published: 22 July 2009
... © The Authors Journal compilation © 2009 Biochemical Society 2009 desorption/ionization on silicon (DIOS) laser desorption mass spectrometry matrix-assisted laser-desorption ionization (MALDI) surface-assisted laser-desorption ionization (SALDI) Biological systems, particularly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1064–1068.
Published: 25 October 2007
... firing [ 12 , 13 ], and play a neuroprotective role under diverse hyperexcitable conditions [ 14 ]. calcineurin electrical signalling ion channel mass spectrometry neuron protein kinase Kv2.1 channels consist of four α-subunit polypeptides, each composed of six membrane-spanning...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (2): 251–256.
Published: 20 March 2006
... The Biochemical Society 2006 antimicrobial peptide defensin mass spectrometry The mammalian innate immune system produces a large array of weapons to protect the host from the constant attack which it is under from micro-organisms [ 1 ]. One important family is the cationic AMPs (antimicrobial...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1476–1478.
Published: 01 December 2003
... correlations into metabolomic networks and their relationships with the underlying biochemical pathways. data mining mass spectrometry metabolic networks metabolomics 1 To whom correspondence should be addressed (e-mail [email protected] ). Unravelling Nature's Networks...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (4): 810–814.
Published: 01 August 2003
..., the nasal and oral mucosa are constantly challenged by different environmental factors, such as micro- organisms, allergens, irritating particles and chemicals, that Key words: epoxy chemical, lipopolysaccharide, mass spectrometry, nasal lavage fluid, PLUNC (palate, lung and nasal epithelial clone), two...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (2): 82–87.
Published: 01 April 2002
... formats. The first involves high-density immo- bilized arrays of recognition molecules (e.g. antibodies), where target binding is monitored Key words: biomarker, mass spectrometry, protein biochip. proteomics. SELDI. Abbreviations used: 2-DE, two-dimensional protein gel electro- phoresis: Qq...
