...Hao Xu; Na-Ryum Bin; Shuzo Sugita Mast cells play pivotal roles in innate and adaptive immunities but are also culprits in allergy, autoimmunity, and cardiovascular diseases. Mast cells respond to environmental changes by initiating regulated exocytosis/secretion of various biologically active...

.... Pathobiology of ischaemic stroke: an integrated view Trends Neurosci. 1999 22 391 397 45 Gonzalez F.F. Ferriero D.M. Therapeutics for neonatal brain injury Pharmacol. Ther. 2008 120 43 53 46 Jin Y. Silverman A.J. Vannucci S.J. Mast cell stabilization limits...

... the production of pro-inflammatory Th2 cytokines. PI3Kδ is also involved in B-cell and mast cell activation. Therefore the inhibition of PI3Kδ should dampen down the inflammatory cascade involved in the asthmatic response through a wide breadth of pharmacology. Current anti-inflammatory therapies, which...

...P.T. Kovanen Mast cells are present in advanced human atherosclerotic plaques, where they are thought to exert multiple effects on their neighbouring cells and on the extracellular matrix of the plaque. Extensive efforts at delineating their role(s) in atherosclerotic plaques have unravelled...

...) lymphocyte mast cell neutrophil phosphoinositide 3-kinase (PI 3-kinase) Abbreviations used: ARDS, acute respiratory distress syndrome; Bad, Bcl-2/Bcl-X L -antagonist, causing cell death; Bcl-2, B-cell leukaemia/lymphoma 2; COPD, chronic obstructive pulmonary disease; EPO, eosinophil peroxidase...

...L. Tabares; M. Lindau; G. Alvarez de Toledo We have studied exocytosis in rat peritoneal mast cells by cell-attached patch amperometry. Step increases in capacitance were accompanied by typical amperometric spikes due to the release of 5-hydroxytryptamine (serotonin), indicating exocytosis...