... of the Biochemical Society 2020 β-catenin integrins mechanosensing stiffness Wnt Wnt/β-catenin pathway The Wnt signaling pathway plays crucial roles during stem cell differentiation, embryonic development, and homeostasis [ 1 ]. The pathway is composed of secreted Wnt ligands and modulators...

... the family. intrasteric regulation mechanosensing obscurin (pseudo)kinase scaffold titin-like kinase twitchin Titin-like kinases form mechanosensory signalling nodes central to myofibril regulation. The speciation of their elastic regulatory segments coupled to kinase/pseudokinase catalytic...