... Mechanotransduction Fluid shear sensing Curvature-based gating Force-from-lipids Force-from-filaments The intricate signaling network orchestrated by PIEZO channels plays crucial roles in a wide array of physiological and pathophysiological functions, including CaMKII-dependent bone formation [ 72...

...James W. Hindley Biological mechanotransduction enables cells to sense and respond to mechanical forces in their local environment through changes in cell structure and gene expression, resulting in downstream changes in cell function. However, the complexity of living systems obfuscates...

... tethered protein has spatially restricted activity ( Figure 1B–D ). As we will illustrate, complex interdependencies can arise by moving these zones of activity relative to each other. enzymology epidermal growth factor receptor mechanotransduction molecular scaffolds signalling talin...

...Delfine Cheng; Junfan Wang; Mingxi Yao; Charles D Cox Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as PIEZO1 are critical in mechanotransduction processes that influence cell differentiation, development, and cancer. Ample evidence now exists for regulatory...

... Attribution License 4.0 (CC BY) . DCM and EDMD mechanotransduction microtubule nesprin nuclear envelope LINC complex nuclear positioning The nuclear envelope (NE) is a highly dynamic organelle providing spatial separation of the nuclear and cytoplasmic environments and protecting the genome...

... ) or Charles D. Cox ( [email protected] ) 20 9 2019 28 10 2019 1 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 amphipaths channel domains mechanotransduction PIEZO channels The eukaryotic cell's ability...

... forces mechanotransduction Correspondence: Lisha Ma ( [email protected] ) 15 1 2016 2 8 2016 15 8 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 Cardiac interstitial fibrosis formation induced in arterial...

... cells, keratinocytes, mammary epithelial cells and smooth muscle cells. In addition, recent evidence suggests a potential role for β-catenin and Smad signalling in mechanotransduction, but further mechanistic studies are needed to prove this hypothesis. As a model system, the epidermis of the skin...

... alter their morphology, function and gene expression. The molecular basis for mechanotransduction of a shear stress signal, and the identity of the sensing mechanisms, remain unclear with many candidates under investigation. Translating these findings in vivo has proved difficult. The role of VEGF...

... in mechanotransduction in intact muscle. 1 To whom correspondence should be addressed (email [email protected] ). 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 focal adhesion kinase (FAK) mechanobiology mechanotransduction phosphorylation striated muscle...

... there are limited studies to date, this paper aims to review current knowledge on F-actin cytoskeletal element organization in intervertebral disc cells, how F-actin differs with pathology and its implications for mechanotransduction. References 1 Waddell G. Neurosurg. Clin. N. Am. 1991 2 719...

.... In addition, each TRP channel family has its own unique set of domains and motifs in the N- or C-terminus. calcium channel mechanotransduction polycystic kidney disease polycystin-1 primary cilium transient receptor potential (TRP) © 2007 The Biochemical Society 2007 17 8 2006...

... actin cytoskeleton cyclic compression gelatin zymography mechanotransduction quantitative PCR MMP, matrix metalloproteinase GAPDH, glyceraldehyde-3-phosphate dehydrogenase Connective Tissue Research Colloquium Organized and Edited by V. Duance (School of Biosciences, Cardiff University...