...David Hardy; Roslyn M. Bill; Anass Jawhari; Alice J. Rothnie Membrane proteins account for a third of the eukaryotic proteome, but are greatly under-represented in the Protein Data Bank. Unfortunately, recent technological advances in X-ray crystallography and EM cannot account for the poor...

...Jemma L. Trick; Prafulla Aryal; Stephen J. Tucker; Mark S. P. Sansom Gating in channels and nanopores plays a key role in regulating flow of ions across membranes. Molecular simulations provide a ‘computational microscope’ which enables us to examine the physical nature of gating mechanisms...

...Syma Khalid; Nils A. Berglund; Daniel A. Holdbrook; Yuk M. Leung; Jamie Parkin Molecular modelling and simulations have been employed to study the membranes of Gram-negative bacteria for over 20 years. Proteins native to these membranes, as well as antimicrobial peptides and drug molecules have...

... them into the clinic. From the simple starting point for triacylglycerol (TG) accumulation in the liver to the more complex implications of phospholipids in membrane biophysics, the influence of lipids may be the clue to understand NAFLD pathophysiology. Nowadays, it is achievable to diagnose non...

...-Martins R. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model Hum. Mol. Genet. 2009 18 4022 4034 24 Biskup S. Moore D.J. Celsi F. Higashi S. West A.B. Andrabi S.A. Kurkinen K...

...J. Malcolm East; Francesco Michelangeli This Biochemical Society Annual Symposium on Recent Advances in Membrane Biochemistry was organized to bring together experts from across the spectrum of biomembrane disciplines from the biological to the biophysical/structural, with the intention...

...Rupak Doshi; Daniel A.P. Gutmann; Yvonne S.K. Khoo; Lisa A. Fagg; Hendrik W. van Veen Multidrug transporters have a crucial role in causing the drug resistance that can arise in infectious micro-organisms and tumours. These integral membrane proteins mediate the export of a broad range of unrelated...

... with other intracellular domains, including the plasma membrane, suggesting that tau may have additional functions other than stabilizing the neuronal cytoskeleton. Localization of tau at the cell surface appears to be dependent on interactions of the N-terminal projection domain of tau. Furthermore...

... as pharmaceutics and nutraceutics; Plant membranes; and Integrating plant functions via signalling molecules: molecular mechanisms. Some of the main problems highlighted in the plenary lectures are briefly summarized in the present paper. Two poster sessions enabled a discussion of over 200 posters presented...

... sorting complex required for transport (ESCRT) membrane small-angle X-ray scattering (SAXS) ubiquitin Early structural studies of the ESCRT (endosomal sorting complex required for transport) system began almost a decade ago and have picked up momentum over the last 5 years. Thanks...

...Tchern Lenn; Mark C. Leake; Conrad W. Mullineaux Most organisms are able to synthesize ATP by OXPHOS (oxidative phosphorylation). Mitochondria in eukaryotes perform OXPHOS in the inner mitochondrial membrane, whereas the plasma membrane is used by prokaryotes. However, whereas OXPHOS is a well...

... that their chemically identical subunits pack stably in geometrically non-equivalent ways. Self-assembly can also involve scaffolds that lack structure, as seen in the multi-enzyme assembly, the degradosome. The stable self-assembly of lipids into dynamic membraneous sheets is also described, and an example is shown...

...C.J. Fielding; P.E. Fielding The plasma membrane of mammalian cells consists of microdomains differing in lipid and protein composition. Two distinct classes of cholesterol/sphingolipid microdomain (caveolae and lipid rafts) are assembly points for transmembrane signalling complexes. Recent...

... processes. In the case of ricin, the process inhibited is protein synthesis. In order to reach their cytosolic substrates, several toxins undergo retrograde transport to the ER (endoplasmic reticulum) before translocating across the ER membrane. To achieve this export, these toxins exploit the ERAD (ER...

...S.E. Harding; P. O'Shea An overview is given of a stimulating Meeting held at the University of Nottingham in June 2003 focusing on molecular interactions occurring in membranes or ‘2D’ and those occurring in aqueous solution or ‘3D’. It was held jointly between the Biochemical Society...

...J. J. Skehel; K. Cross; D. Steinhauer; D. C. Wiley The ‘fusion peptides’ of a group of enveloped viruses that includes influenza, paramyxo-, retro-and filo-viruses are N-terminal regions of their membrane fusion proteins generated by cleavage of non-functional precursors. For the influenza membrane...

.... The present article summarizes our studies indicating that rather low concentrations of Aβ significantly alter the fluidity of cell membranes and subcellular fractions from different tissues and different species including humans, as a possible initial step of its biological effects. Using different...

...J. K. Chugh; B. A. Wallace Peptaibols are membrane-active polypeptides isolated from fungal sources. They are characterized by the presence of an unusual amino acid, α-aminoisobutyric acid, and a C-terminal hydroxylated amino acid. Peptaibols exhibit antibiotic activity against bacteria and fungi...