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Keyword: membrane protein
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Articles
Biochem Soc Trans (2016) 44 (3): 883-890.
Published: 09 June 2016
... membrane protein Mms6 Nanoscale inorganic materials are important in an increasingly nanotechnological world. More specifically, magnetic nanoparticles (MNPs) have wide ranging uses from targeted drug delivery [ 1 ], to ultrahigh-density data storage [ 2 ]. Magnetite MNPs are particularly useful...
Articles
Biochem Soc Trans (2013) 41 (1): 185-190.
Published: 29 January 2013
... © The Authors Journal compilation © 2013 Biochemical Society 2013 detergent G-protein-coupled receptor membrane protein thermostability Determining the structures of proteins by X-ray diffraction relies on generating milligram quantities of pure, correctly folded material, which can...
Articles
Biochem Soc Trans (2012) 40 (6): 1291-1294.
Published: 21 November 2012
... structure and functional mechanisms of this focal protein. Understanding the structure and function of membrane proteins is hampered by inherent difficulties associated with their purification since the choice of the detergents play a critical role in the protein structure and stability. In the present mini...
Articles
Biochem Soc Trans (2011) 39 (3): 747-750.
Published: 20 May 2011
...Gunnar von Heijne Membrane proteins currently receive a lot of attention, in large part thanks to a steady stream of high-resolution X-ray structures. Although the first few structures showed proteins composed of tightly packed bundles of very hydrophobic more or less straight transmembrane α...
Articles
Biochem Soc Trans (2011) 39 (3): 761-766.
Published: 20 May 2011
...Anthony G. Lee Intrinsic membrane proteins are solvated by a shell of lipid molecules interacting with the membrane-penetrating surface of the protein; these lipid molecules are referred to as annular lipids. Lipid molecules are also found bound between transmembrane α-helices; these are referred...
Articles
Biochem Soc Trans (2011) 39 (3): 813-818.
Published: 20 May 2011
... purified away from all others. For soluble proteins, this process is greatly aided by the lack of any restriction on the free and independent diffusion of individual protein particles in three dimensions. This is not the case for membrane proteins, as the membrane itself forms a continuum that joins the...
Articles
Biochem Soc Trans (2011) 39 (3): 751-760.
Published: 20 May 2011
... intersubunit interactions of membrane protein complexes that contain both hydrophobic and hydrophilic subunits. In the present paper, we focus on the vitamin B 12 importer of Escherichia coli , BtuCD, that contains two transmembrane BtuC subunits and two ATP-binding BtuD subunits. We have studied the factors...
Articles
Biochem Soc Trans (2011) 39 (3): 767-774.
Published: 20 May 2011
...William Dowhan; Mikhail Bogdanov To determine how the lipid environment affects membrane protein structure and function, strains of Escherichia coli were developed in which normal phospholipid composition can be altered or foreign lipids can be introduced. The properties of LacY (lactose permease...
Articles
Biochem Soc Trans (2011) 39 (3): 707-718.
Published: 20 May 2011
... 18 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 glutamate receptor hetero-oligomeric protein ionotropic receptor membrane protein N -methyl- D -aspartate receptor (NMDA receptor) tandem affinity purification-tagged mouse (TAP-tagged mouse) The...
Articles
Biochem Soc Trans (2009) 37 (4): 643-652.
Published: 22 July 2009
...Paul Curnow Integral membrane proteins are important biological macromolecules with structural features and functionalities that make them attractive targets for nanotechnology. I provide here a broad review of current activity in nanotechnology related to membrane proteins, including their...
Articles
Biochem Soc Trans (2009) 37 (2): 392-399.
Published: 20 March 2009
... compilation © 2009 Biochemical Society 2009 electron transfer haem-copper oxidase membrane protein nitric oxide nitrous oxide proton transfer The volume of nitrous oxide (N 2 O) discharged into the atmosphere each year is lower compared with carbon dioxide (CO 2 ) and methane. However...
Articles
Biochem Soc Trans (2009) 37 (2): 400-407.
Published: 20 March 2009
... structure and mechanism of the purple bacterial RC, focusing in the main on the most heavily studied complex from Rhodobacter sphaeroides . 1 email m.r.jones@bristol.ac.uk 14 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 electron transfer membrane...
Articles
Biochem Soc Trans (2008) 36 (6): 1169-1174.
Published: 19 November 2008
... Society 2008 electron transfer haem-copper oxidase membrane protein proton pump proton transfer redox reaction Cyt c O catalyses the oxidation of four molecules of cytochrome c and the reduction of O 2 to H 2 O ( eqn 1a ). The electrons are donated from the relatively positive ( P...
Articles
Biochem Soc Trans (2008) 36 (5): 996-1000.
Published: 19 September 2008
...C. Roy D. Lancaster; Elena Herzog; Hanno D. Juhnke; M. Gregor Madej; Florian G. Müller; Rajsekhar Paul; Philipp G. Schleidt Membrane protein complexes can support both the generation and utilization of a transmembrane electrochemical proton potential (Δ p ), either by supporting transmembrane...
Articles
Biochem Soc Trans (2008) 36 (1): 27-32.
Published: 22 January 2008
...Mark S.P. Sansom; Kathryn A. Scott; Peter J. Bond An understanding of the interactions of membrane proteins with a lipid bilayer environment is central to relating their structure to their function and stability. A high-throughput approach to prediction of membrane protein interactions with a lipid...
Articles
Biochem Soc Trans (2007) 35 (5): 835-847.
Published: 25 October 2007
... Environmental Microbiology, College of Life Sciences, University of Dundee DD1 5EH, Scotland, U. K. (email fsargent@dundee.ac.uk ). 14 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 membrane protein membrane transport molecular chaperone protein–protein...
Articles
Biochem Soc Trans (2005) 33 (6): 1225-1230.
Published: 26 October 2005
... secretion and membrane insertion. 1 email: ian.collinson@bristol.ac.uk 22 7 2005 © 2005 The Biochemical Society 2005 membrane protein protein translocation secretion SecYEG translocon Polypeptide transport and import usually occurs when they are in an unfolded state...
Includes: Multimedia, Supplementary data
Articles
Biochem Soc Trans (2005) 33 (5): 924-930.
Published: 26 October 2005
... 6 2005 © 2005 The Biochemical Society 2005 detergent lipid membrane protein protein engineering reaction centre X-ray crystallography The (bacterio)chlorophyll-containing membrane proteins that catalyse photosynthetic energy transduction are naturally abundant, and are...
Articles
Biochem Soc Trans (2005) 33 (5): 996-999.
Published: 26 October 2005
...N.H. Awayn; M.F. Rosenberg; A.B. Kamis; L.A. Aleksandrov; J.R. Riordan; R.C. Ford Cystic fibrosis, one of the major human inherited diseases, is caused by defects in the CFTR (cystic fibrosis transmembrane conductance regulator), a cell-membrane protein. CFTR acts as a chloride channel which can be...
Articles
Biochem Soc Trans (2005) 33 (5): 938-942.
Published: 26 October 2005
...C. Hunte Many membrane proteins selectively bind defined lipid species. This specificity has an impact on correct insertion, folding, structural integrity and full functionality of the protein. How are these different tasks achieved? Recent advances in structural research of membrane proteins...
Articles
Biochem Soc Trans (2005) 33 (5): 910-912.
Published: 26 October 2005
...P.J. Bond; J. Cuthbertson; M.S.P. Sansom Interactions between membrane proteins and detergents are important in biophysical and structural studies and are also biologically relevant in the context of folding and transport. Despite a paucity of high-resolution data on protein–detergent interactions...
Articles
Biochem Soc Trans (2005) 33 (5): 1012-1015.
Published: 26 October 2005
...S.H. White; G. von Heijne Membrane-protein integration, folding and assembly processes in vivo depend on complex targeting, translocation, chaperoning, and sorting machineries that somehow read the ‘molecular code’ built into the nascent polypeptide, ultimately producing a properly folded protein...
Articles
Biochem Soc Trans (2005) 33 (4): 851-857.
Published: 01 August 2005
... © 2005 The Biochemical Society 2005 bacteriochlorophyll electron transfer membrane protein photosynthetic bacteria protein engineering reaction centre Publication of the X-ray crystal structure of the Rhodopseudomonas viridis reaction centre in the mid-1980s revealed the beautiful...
Articles
Biochem Soc Trans (2005) 33 (1): 56-58.
Published: 01 February 2005
... 2005 heterologous expression membrane protein redox enzyme Rhodobacter capsulatus T 7 RNA-polymerase uptake hydrogenase Among photosynthetic prokaryotes, the non-sulphur purple bacterium R. capsulatus has been widely used in genetic studies of physiology and regulation of...
Articles
Biochem Soc Trans (2004) 32 (6): 1122-1123.
Published: 26 October 2004
... in cellular differentiation and its disorders. 1 To whom correspondence should be addressed (email WS.Gilmore@ulster.ac.uk ). 8 7 2004 © 2004 The Biochemical Society 2004 annexin differentiation haematopoiesis membrane protein Annexins are a family of homologous...
Articles
Biochem Soc Trans (2004) 32 (6): 1130-1132.
Published: 26 October 2004
...-associated membrane protein and, thus, could help phagocytosed bacteria escape killing within macrophages [ 10 ]. Neisseria is capable of modulating programmed cell death (apoptosis) by blocking the action of TNFα (tumour necrosis factor α). The type II TNF receptor was cleaved specifically after the...
Articles
Biochem Soc Trans (2004) 32 (5): 659-662.
Published: 26 October 2004
...S. High; B.M. Abell The post-translational integration of tail-anchored proteins at the endoplasmic reticulum represents a novel and distinct pathway for membrane protein synthesis. Studies of various precursors, exemplified by the synaptobrevins and cytochrome b5 , indicate that multiple routes...
Articles
Biochem Soc Trans (2004) 32 (5): 738-741.
Published: 26 October 2004
... membrane protein retinal protein vision water A variety of physiological processes mediated by biological membranes involve heptahelical transmembrane receptors. In eukaryotic organisms, they constitute a large protein family termed as GPCRs (G-protein-coupled receptors). Owing to the lack of...
Articles
Biochem Soc Trans (2004) 32 (3): 520-523.
Published: 01 June 2004
... Biochemical Society Focused Meeting held at Rothamsted Research, Harpenden, 25 November 2003 25 November 2003 © 2004 Biochemical Society 2004 Golgi isotope-coded affinity tag (ICAT) membrane protein organelle quantitative proteomics Abbreviations used: 2D, two-dimensional...
Articles
Biochem Soc Trans (2002) 30 (4): 715-718.
Published: 01 August 2002
... © 2002 Biochemical Society 2002 heavy metal ion transport membrane protein mercuric ion resistance Biometals 2002: Third International Biometals Symposium: Focused Meeting Organized by S. Andrews (School of Animal and Microbial Sciences, University of Reading), R. Cammack, R. W. Evans...
Articles
Biochem Soc Trans (2001) 29 (6): 732-736.
Published: 01 November 2001
...J. A. Schmid; H. Just; H. H. Sitte The formation of oligomeric structures has been proposed for a large number of membrane proteins, including G-protein-coupled receptors and ion channels. Biochemical studies employing gel filtration, cross-linking or co-immunoprecipitation techniques showed that...
Articles
Biochem Soc Trans (2001) 29 (4): 589-593.
Published: 01 August 2001
...P. I. Haris It is estimated that membrane proteins comprise as much as 30% of most genomes. Yet our knowledge of membrane-protein folding is still in its infancy. Consequently, there is a great need for developing approaches that can further advance our understanding of how peptides and proteins...
Articles
Biochem Soc Trans (2001) 29 (4): 559-564.
Published: 01 August 2001
...J. D. Lear; H. Gratkowski; W. F. DeGrado Our current level of understanding of membrane-protein folding is primitive, but it is beginning to advance. Previously [Choma, Gratkowski, Lear and DeGrado (2000) Nat. Struct. Biol. 7, 161–166], we described studies of the association in detergent micelles...