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Keyword: membrane proteins
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Articles
Biochem Soc Trans (2019) 47 (5): 1233-1245.
Published: 11 October 2019
...Paul Curnow The construction of artificial membrane proteins from first principles is of fundamental interest and holds considerable promise for new biotechnologies. This review considers the potential advantages of adopting a strictly minimalist approach to the process of membrane protein design...
Articles
Biochem Soc Trans (2019) 47 (1): 317-327.
Published: 15 January 2019
... of age. Finally, we outline key developments that have enabled membrane protein native MS to shift from being extremely challenging to routine, and how this technique is uncovering inaccessible details of membrane protein–lipid interactions. Correspondence: Timothy M. Allison ( timothy.allison...
Articles
Biochem Soc Trans (2019) 47 (1): 47-61.
Published: 17 December 2018
...Rosana Reis; Isabel Moraes The study of structure–function relationships of membrane proteins (MPs) has been one of the major goals in the field of structural biology. Many Noble Prizes regarding remarkable accomplishments in MP structure determination and biochemistry have been awarded over the...
Articles
Biochem Soc Trans (2018) 46 (6): 1495-1504.
Published: 21 November 2018
...Kailene S. Simon; Naomi L. Pollock; Sarah C. Lee The use of styrene–maleic acid (SMA) for the purification of a wide range of membrane proteins (MPs) from both prokaryotic and eukaryotic sources has begun to make an impact in the field of MP biology. This method is growing in popularity as a means...
Articles
Biochem Soc Trans (2017) 45 (2): 401-408.
Published: 13 April 2017
...Shweta Varshney; Pamela Stanley Here, we describe a recently discovered O -GlcNAc transferase termed EOGT for EGF domain-specific O -GlcNAc transferase. EOGT transfers GlcNAc ( N -acetylglucosamine) to Ser or Thr in secreted and membrane proteins that contain one or more epidermal growth factor...
Articles
Biochem Soc Trans (2017) 45 (1): 15-26.
Published: 15 February 2017
...Paul A. Beales; Sanobar Khan; Stephen P. Muench; Lars J.C. Jeuken The application of membrane proteins in biotechnology requires robust, durable reconstitution systems that enhance their stability and support their functionality in a range of working environments. Vesicular architectures are highly...
Articles
Biochem Soc Trans (2017) 45 (1): 251-260.
Published: 15 February 2017
... dehydration in vacuum [ 41 ]. Perhaps for me my ultimate goal has been to study membrane proteins from an environment that is as close to the natural membrane as possible. Interestingly, the commentary back in 1995 [ 1 ] said that ‘The vacuum being very apolar can be thought of as a very hydrophobic...
Articles
Biochem Soc Trans (2016) 44 (4): 1011-1018.
Published: 15 August 2016
...Sarah C. Lee; Sarah C. Lee; Naomi L. Pollock The use of styrene maleic acid lipid particles (SMALPs) for the purification of membrane proteins (MPs) is a rapidly developing technology. The amphiphilic copolymer of styrene and maleic acid (SMA) disrupts biological membranes and can extract membrane...
Articles
Biochem Soc Trans (2016) 44 (3): 877-882.
Published: 09 June 2016
...Mayuriben J. Parmar; Carine De Marcos Lousa; Stephen P. Muench; Adrian Goldman; Vincent L.G. Postis Membrane proteins represent one of the most important targets for pharmaceutical companies. Unfortunately, technical limitations have long been a major hindrance in our understanding of the function...
Articles
Biochem Soc Trans (2016) 44 (3): 790-795.
Published: 09 June 2016
...Andrea E. Rawlings Membrane proteins play crucial roles in cellular processes and are often important pharmacological drug targets. The hydrophobic properties of these proteins make full structural and functional characterization challenging because of the need to use detergents or other...
Articles
Biochem Soc Trans (2015) 43 (5): 773-786.
Published: 09 October 2015
... Aquired Resistance to Targeted Cancer Therapeutics conference. Held at Robinson College, Cambridge, U.K., 5–7 January 2015. 20 3 2015 © 2015 Authors; published by Portland Press Limited 2015 hydrogen deuterium exchange–mass spectrometry (HDX–MS) membrane proteins phosphoinositide 3...
Articles
Biochem Soc Trans (2000) 28 (4): 513-517.
Published: 01 August 2000
... + antiport of substrates such as quinolones and ethidium and exemplify a family of putatively 12-helix membrane proteins. The gene for each protein was cloned downstream of the tac promoter in plasmid pTTQ18; an oligonucleotide encoding six histidine residues was added, in frame, to the C-terminus to...
Articles
Biochem Soc Trans (2000) 28 (4): 491-494.
Published: 01 August 2000
... exclusively by hydrophobic thylakoid membrane proteins; here we review recent progress in our understanding of the biogenesis of this important class of protein. 1 To whom correspondence should be addressed (e-mail cg@dna.bio.warwick.ac.uk ) 6 3 2000 © 2000 Biochemical Society 2000...