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Keywords: membrane proteins
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Biochem Soc Trans (2023) BST20220611.
Published: 20 January 2023
... membrane proteins Mycobacterium tuberculosis protein structure Bacteria of the genus Mycobacterium include pathogenic species such as M. tuberculosis , M. leprae , M. avium , M. abscessus (sometimes called Mycobacteroides abscessus ), and M. ulcerans, as well as non-pathogenic species...
Biochem Soc Trans (2022) 50 (6): 1763–1772.
Published: 23 November 2022
... Mancia ( fm123@cumc.columbia.edu ) 20 9 2022 3 11 2022 7 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cryo-EM membrane proteins palmitoleation WLS Wnt proteins Wnts are short-range signaling proteins...
Biochem Soc Trans (2022) 50 (5): 1257–1267.
Published: 10 October 2022
..., increasing Δ d , to relieve the pressure (right panel). ( B ) Low (left panel) and high (right panel) density of Epsin1 ENTH domain in phase separated GUV membranes. Protein diffusion is limited by phase separation into lo (red) and ld (green) domains, resulting in spontaneous tubulation at high...
Biochem Soc Trans (2022) 50 (3): 1057–1067.
Published: 13 June 2022
... for the analytical tools used to investigate these systems of increased size and complexity, such as Native Mass Spectrometry, which has always been an important tool for structural biology. Scientific advance and recent developments, such as new ways to mimic a cell membrane for a membrane protein, have caused...
Biochem Soc Trans (2022) 50 (1): 555–567.
Published: 25 February 2022
...Ryan Brady; Nicola J. Harris; Grant A. Pellowe; Samuel Gulaidi Breen; Paula J. Booth Membrane proteins need to fold with precision in order to function correctly, with misfolding potentially leading to disease. The proteins reside within a hydrophobic lipid membrane and must insert...
Biochem Soc Trans (2021) 49 (6): 2749–2765.
Published: 08 November 2021
... challenges, problems, and approaches to studying PFPs. agricultural bioscience imaging techniques membrane proteins nanotechnology pore-forming toxins protein engineering Pore-forming proteins (PFPs) represent a highly diverse and growing class of molecules identified in all kingdoms of life...
Biochem Soc Trans (2021) 49 (5): 2037–2050.
Published: 13 October 2021
...Stephanie A. Nestorow; Tim R. Dafforn; Verna Frasca Membrane proteins such as receptors, ion channels and transport proteins are important drug targets. The structure-based study of membrane proteins is challenging, especially when the target protein contains both soluble and insoluble domains...
Biochem Soc Trans (2021) 49 (4): 1763–1777.
Published: 20 August 2021
...Giedre Ratkeviciute; Benjamin F. Cooper; Timothy J. Knowles The solubilisation of membrane proteins (MPs) necessitates the overlap of two contradictory events; the extraction of MPs from their native lipid membranes and their subsequent stabilisation in aqueous environments. Whilst the current...
Biochem Soc Trans (2021) 49 (3): 1349–1359.
Published: 10 June 2021
...Lucas Unger; Alejandro Ronco-Campaña; Philip Kitchen; Roslyn M. Bill; Alice J. Rothnie In the twelve years since styrene maleic acid (SMA) was first used to extract and purify a membrane protein within a native lipid bilayer, this technological breakthrough has provided insight into the structural...
Biochem Soc Trans (2021) 49 (3): 1189–1203.
Published: 08 June 2021
... biosynthetic strategy by catalyzing the transfer of a phospho-sugar from a nucleoside diphospho-sugar to a membrane-resident polyprenol phosphate. Studies on the PGTs have been hampered because they are integral membrane proteins, and often prove to be recalcitrant to expression, purification and analysis...
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
... resolution. This is especially true for challenging targets such as membrane proteins (MPs). Understanding structure-function relationships of MPs at the biochemical level is vital for medicine and drug discovery as they play critical roles in many cellular processes. Though difficult, structure...
Biochem Soc Trans (2020) 48 (4): 1473–1492.
Published: 24 August 2020
...Andrea Marco Amati; Simone Graf; Sabina Deutschmann; Nicolas Dolder; Christoph von Ballmoos Membrane proteins (MPs) are the gatekeepers between different biological compartments separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they fulfill a wide variety...
Biochem Soc Trans (2020) 48 (3): 971–979.
Published: 29 June 2020
...Andy M. Lau; Ruyu Jia; Richard T. Bradshaw; Argyris Politis HDX-MS has emerged as a powerful tool to interrogate the structure and dynamics of proteins and their complexes. Recent advances in the methodology and instrumentation have enabled the application of HDX-MS to membrane proteins...
Biochem Soc Trans (2020) 48 (3): 1089–1099.
Published: 07 May 2020
... nuclear polarization membrane proteins pathogenic fungi polysaccharides solid-state NMR Because radicals are paramagnetic species, spins in their spatial vicinity experience faster NMR relaxation, which leads to line broadening and intensity suppression [ 49 , 50 ]. The signal quenching, also...
Biochem Soc Trans (2020) 48 (3): 1227–1241.
Published: 05 May 2020
...Alisa A. Garaeva; Dirk J. Slotboom Membrane transporters are integral membrane proteins that mediate the passage of solutes across lipid bilayers. These proteins undergo conformational transitions between outward- and inward-facing states, which lead to alternating access of the substrate-binding...
Biochem Soc Trans (2019) 47 (5): 1233–1245.
Published: 11 October 2019
...Paul Curnow The construction of artificial membrane proteins from first principles is of fundamental interest and holds considerable promise for new biotechnologies. This review considers the potential advantages of adopting a strictly minimalist approach to the process of membrane protein design...
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
.... Finally, we outline key developments that have enabled membrane protein native MS to shift from being extremely challenging to routine, and how this technique is uncovering inaccessible details of membrane protein–lipid interactions. Correspondence: Timothy M. Allison ( timothy.allison...
Biochem Soc Trans (2019) 47 (1): 47–61.
Published: 17 December 2018
...Rosana Reis; Isabel Moraes The study of structure–function relationships of membrane proteins (MPs) has been one of the major goals in the field of structural biology. Many Noble Prizes regarding remarkable accomplishments in MP structure determination and biochemistry have been awarded over...
Biochem Soc Trans (2018) 46 (6): 1495–1504.
Published: 21 November 2018
...Kailene S. Simon; Naomi L. Pollock; Sarah C. Lee The use of styrene–maleic acid (SMA) for the purification of a wide range of membrane proteins (MPs) from both prokaryotic and eukaryotic sources has begun to make an impact in the field of MP biology. This method is growing in popularity as a means...
Biochem Soc Trans (2017) 45 (2): 401–408.
Published: 13 April 2017
...Shweta Varshney; Pamela Stanley Here, we describe a recently discovered O -GlcNAc transferase termed EOGT for EGF domain-specific O -GlcNAc transferase. EOGT transfers GlcNAc ( N -acetylglucosamine) to Ser or Thr in secreted and membrane proteins that contain one or more epidermal growth factor...
Biochem Soc Trans (2017) 45 (1): 251–260.
Published: 15 February 2017
... ]. Combining our membrane protein MS with the unfolding experiments described above, we were able to identify lipids that affect the structure of the ammonia channel (AmtB) and for the function of aquaporin Z. That led to the first lipid-bound structure of AmtB [ 53 ]. Similarly, MS was used to inform...
Biochem Soc Trans (2017) 45 (1): 15–26.
Published: 15 February 2017
...Paul A. Beales; Sanobar Khan; Stephen P. Muench; Lars J.C. Jeuken The application of membrane proteins in biotechnology requires robust, durable reconstitution systems that enhance their stability and support their functionality in a range of working environments. Vesicular architectures are highly...
Biochem Soc Trans (2016) 44 (4): 1011–1018.
Published: 15 August 2016
...Sarah C. Lee; Naomi L. Pollock The use of styrene maleic acid lipid particles (SMALPs) for the purification of membrane proteins (MPs) is a rapidly developing technology. The amphiphilic copolymer of styrene and maleic acid (SMA) disrupts biological membranes and can extract membrane proteins...
Biochem Soc Trans (2016) 44 (3): 877–882.
Published: 09 June 2016
...Mayuriben J. Parmar; Carine De Marcos Lousa; Stephen P. Muench; Adrian Goldman; Vincent L.G. Postis Membrane proteins represent one of the most important targets for pharmaceutical companies. Unfortunately, technical limitations have long been a major hindrance in our understanding of the function...
Biochem Soc Trans (2016) 44 (3): 790–795.
Published: 09 June 2016
...Andrea E. Rawlings Membrane proteins play crucial roles in cellular processes and are often important pharmacological drug targets. The hydrophobic properties of these proteins make full structural and functional characterization challenging because of the need to use detergents or other...
Biochem Soc Trans (2015) 43 (5): 773–786.
Published: 09 October 2015
... and development of HDX–MS and its application to examine the molecular basis of lipid signalling enzymes, specifically the regulation and activation of phosphoinositide 3-kinases (PI3Ks). hydrogen deuterium exchange–mass spectrometry (HDX–MS) membrane proteins phosphoinositide 3-kinases (PI3Ks) protein...
Biochem Soc Trans (2000) 28 (4): 513–517.
Published: 01 August 2000
... + antiport of substrates such as quinolones and ethidium and exemplify a family of putatively 12-helix membrane proteins. The gene for each protein was cloned downstream of the tac promoter in plasmid pTTQ18; an oligonucleotide encoding six histidine residues was added, in frame, to the C-terminus...
Biochem Soc Trans (2000) 28 (4): 491–494.
Published: 01 August 2000
... exclusively by hydrophobic thylakoid membrane proteins; here we review recent progress in our understanding of the biogenesis of this important class of protein. 1 To whom correspondence should be addressed (e-mail cg@dna.bio.warwick.ac.uk ) 6 3 2000 © 2000 Biochemical Society 2000...