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Keywords: metastasis
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Biochem Soc Trans (2023) 51 (5): 1881–1895.
Published: 06 October 2023
... and alter cell behaviour. Whilst peroxidasin is reported to be up-regulated in a number of different cancers, the role that it plays in disease progression and metastasis has only recently begun to be studied. This review highlights the current literature exploring the known roles of peroxidasin in normal...
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Biochem Soc Trans (2023) 51 (4): 1559–1569.
Published: 25 August 2023
... to collectively co-ordinate such polarisation between cells allows for the genesis of multicellularity, such as the formation of organs. During tumourigenesis, the rules for such tissue polarisation become dysregulated, allowing for collective polarity rearrangements that can drive metastasis. In this review, we...
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Biochem Soc Trans (2022) 50 (3): 1245–1257.
Published: 17 June 2022
...Ryan Lusby; Philip Dunne; Vijay K. Tiwari Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter representing the leading cause of death in cancer patients. Whilst many advances in this area have been made in recent years, the process of cancer dissemination...
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Biochem Soc Trans (2021) 49 (6): 2581–2589.
Published: 02 December 2021
... implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches...
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Biochem Soc Trans (2021) 49 (3): 1425–1442.
Published: 01 July 2021
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cancer Cdc42 metastasis Rho GTPases R147S and K150N in α4 helix could represent mutations that alter Cdc42 membrane orientation and effector engagement. Helix α4 has been described as switch...
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Biochem Soc Trans (2021) 49 (3): 1409–1423.
Published: 08 June 2021
...-step process, called metastasis, disseminates cancer cells primarily through vascular routes. The major steps of the metastatic cascade comprise intravasation into blood vessels, circulation as single or collectives of cells, and eventual colonization of distant organs. Herein, we consider metastasis...
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Biochem Soc Trans (2020) 48 (6): 2539–2555.
Published: 05 November 2020
... different effects on the components of the ECM driving or inhibiting augmented angiogenesis and tumour progression and tumour cell proliferation and metastasis. These effects rely on the concentration of NO within the tumour tissue, the nature of the surrounding microenvironment and the sensitivity...
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Biochem Soc Trans (2019) 47 (6): 1661–1678.
Published: 22 November 2019
... Limited on behalf of the Biochemical Society 2019 cancer extracellular matrix fibrosis lysyl oxidases metastasis The amorphous material present between cells in tissues and organs was initially referred to in 1852 as ‘Grundsubstanz', translating roughly to ‘basic or fundamental substance...
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Biochem Soc Trans (2019) 47 (2): 517–526.
Published: 01 April 2019
... metastasis sterols Oxysterols are usually measured by gas chromatography–mass spectrometry (GC–MS) methods incorporating selected-ion monitoring [ 26 , 27 ] or liquid chromatography tandem–mass spectrometry (LC–MS/MS) methods exploiting multiple reaction monitoring [ 28 ]. When an alkaline...
Includes: Supplementary data
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Biochem Soc Trans (2019) 47 (1): 101–108.
Published: 17 December 2018
...: Michael Samuel ( [email protected] ) 12 9 2018 27 10 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 extracellular matrix fibroblasts metastasis tumor microenvironments Tumor progression...
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Biochem Soc Trans (2018) 46 (6): 1517–1527.
Published: 12 November 2018
..., and promote carcinogenesis and metastasis formation. Importantly, the role of platelets in tumor immune escape has been described. These lines of evidence open the way to novel strategies to fight cancer based on the use of antiplatelet agents. In addition to their ability to release factors, platelets...
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Biochem Soc Trans (2018) 46 (5): 1137–1146.
Published: 09 October 2018
... highlight how some of the unique properties of EVs are being used for the development of novel diagnostic and clinical applications. extracellular vesicles microvesicles shedding vesicles metastasis intercellular communication tumor microenvironment Analysis of the cargo within the exosomes...
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Biochem Soc Trans (2017) 45 (2): 465–475.
Published: 13 April 2017
... in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility...
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Biochem Soc Trans (2016) 44 (5): 1305–1312.
Published: 19 October 2016
..., and metastasis, and have been proposed as potential biomarkers of cancer progression [ 3 ]. As the first of the three PRLs, PRL-3 was found overexpressed in liver metastasis from colon cancer but not in normal colon tissue or in primary tumors [ 4 ]. This finding has drawn much attention to this protein, and PRL...
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Biochem Soc Trans (2015) 43 (4): 707–714.
Published: 03 August 2015
... cyclooxygenase 1 (COX-1) cyclooxygenase 2 (COX-2) epithelial mesenchymal transition metastasis platelets Platelets are chief effector cells in haemostasis but they are also inflammatory cells. In fact, they play a central role in the cross-talk with stromal and immune cells leading...
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Biochem Soc Trans (2012) 40 (4): 870–874.
Published: 20 July 2012
... AS of key genes and the initiation of prostate cancer metastasis. 1 Correspondence may be addressed to either author (email [email protected] or [email protected] ). 31 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 alternative splicing...
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Biochem Soc Trans (2012) 40 (1): 79–84.
Published: 19 January 2012
.... In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize...
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Biochem Soc Trans (2012) 40 (1): 94–100.
Published: 19 January 2012
... in cancer progression including cell transformation/oncogenesis, cell survival/apoptosis, cell migration/metastasis and tumour microenvironment neovascularization. In the present paper, we describe our research findings regarding the correlation of sphingosine kinase 1 and S1P receptor expression in tumours...
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Biochem Soc Trans (2007) 35 (4): 704–706.
Published: 20 July 2007
... arrows) above the substratum associated with the actin in the plane of the cell. collagen degradation confocal microscopy fibroblast membrane-type 1 matrix metalloproteinase (MT1-MMP) metastasis phagocytosis Degradation of collagen is a fundamentally important process...
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Biochem Soc Trans (2005) 33 (6): 1282–1284.
Published: 26 October 2005
... The Biochemical Society 2005 ADP-ribosylation factor-GTPase-activating protein (Arf-GAP) Arf-GAP containing Src homology domain ankyrin repeats pleckstrin homology domains 1 (ASAP1) cancer centaurin β4 development and differentiation-enhancing factor 1 (DDEF1) metastasis Mammals have six...
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Biochem Soc Trans (2004) 32 (2): 355–359.
Published: 01 April 2004
... candidate targets for therapeutic intervention in patients with PTEN-deficient tumours. basement membrane gene expression array gene silencing metastasis phosphoinositide 3-kinase PTEN (phosphatase and tensin homologue deleted on chromosome 10) Abbreviations used: GB, GeneBloc; p110...
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