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Keywords: metastasis
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Biochem Soc Trans (2023) 51 (5): 1881–1895.
Published: 06 October 2023
... and alter cell behaviour. Whilst peroxidasin is reported to be up-regulated in a number of different cancers, the role that it plays in disease progression and metastasis has only recently begun to be studied. This review highlights the current literature exploring the known roles of peroxidasin in normal...
Biochem Soc Trans (2023) 51 (4): 1559–1569.
Published: 25 August 2023
... to collectively co-ordinate such polarisation between cells allows for the genesis of multicellularity, such as the formation of organs. During tumourigenesis, the rules for such tissue polarisation become dysregulated, allowing for collective polarity rearrangements that can drive metastasis. In this review, we...
Biochem Soc Trans (2022) 50 (3): 1245–1257.
Published: 17 June 2022
...Ryan Lusby; Philip Dunne; Vijay K. Tiwari Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter representing the leading cause of death in cancer patients. Whilst many advances in this area have been made in recent years, the process of cancer dissemination...
Biochem Soc Trans (2021) 49 (6): 2581–2589.
Published: 02 December 2021
... implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches...
Biochem Soc Trans (2021) 49 (3): 1425–1442.
Published: 01 July 2021
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cancer Cdc42 metastasis Rho GTPases The human homologue of Saccharomyces cerevisiae CDC42 (cell division control protein 42) was identified in 1990 [ 1 , 2 ] and Cdc42 joined the Rho...
Biochem Soc Trans (2021) 49 (3): 1409–1423.
Published: 08 June 2021
...-step process, called metastasis, disseminates cancer cells primarily through vascular routes. The major steps of the metastatic cascade comprise intravasation into blood vessels, circulation as single or collectives of cells, and eventual colonization of distant organs. Herein, we consider metastasis...
Biochem Soc Trans (2020) 48 (6): 2539–2555.
Published: 05 November 2020
... different effects on the components of the ECM driving or inhibiting augmented angiogenesis and tumour progression and tumour cell proliferation and metastasis. These effects rely on the concentration of NO within the tumour tissue, the nature of the surrounding microenvironment and the sensitivity...
Biochem Soc Trans (2019) 47 (6): 1661–1678.
Published: 22 November 2019
... Limited on behalf of the Biochemical Society 2019 cancer extracellular matrix fibrosis lysyl oxidases metastasis The amorphous material present between cells in tissues and organs was initially referred to in 1852 as ‘Grundsubstanz', translating roughly to ‘basic or fundamental substance...
Biochem Soc Trans (2019) 47 (2): 517–526.
Published: 01 April 2019
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cholesterol cytochrome p450 Hedgehog Huntington's disease metastasis sterols Oxysterols are oxidised forms of cholesterol or of its...
Includes: Supplementary data
Biochem Soc Trans (2019) 47 (1): 101–108.
Published: 17 December 2018
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 extracellular matrix fibroblasts metastasis tumor microenvironments Tumor progression culminating in metastasis underlies cancer mortality and it is estimated that ∼90% of all cancer...
Biochem Soc Trans (2018) 46 (6): 1517–1527.
Published: 12 November 2018
..., and promote carcinogenesis and metastasis formation. Importantly, the role of platelets in tumor immune escape has been described. These lines of evidence open the way to novel strategies to fight cancer based on the use of antiplatelet agents. In addition to their ability to release factors, platelets...
Biochem Soc Trans (2018) 46 (5): 1137–1146.
Published: 09 October 2018
... shRNA was shown to inhibit the acidification and degradative activity of lysosomes, resulting in the increased production of exosomes that promoted metastasis [ 37 ]. In line with these findings, inhibiting lysosomal activity by treating cells with Chloroquine or Bafilomycin has been consistently shown...
Biochem Soc Trans (2017) 45 (2): 465–475.
Published: 13 April 2017
... in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility...
Biochem Soc Trans (2016) 44 (5): 1305–1312.
Published: 19 October 2016
... (a TRX-related protein) reduces the PRLs protecting them from oxidation and, in consequence, maintaining their activity and thus contributing to cancer progression and metastasis [ 34 ]. Correspondence: Maja Köhn ( koehn@embl.de ) 2 6 2016 4 7 2016 11 7 2016 © 2016...
Biochem Soc Trans (2015) 43 (4): 707–714.
Published: 03 August 2015
... cyclooxygenase 1 (COX-1) cyclooxygenase 2 (COX-2) epithelial mesenchymal transition metastasis platelets Platelets are chief effector cells in haemostasis but they are also inflammatory cells. In fact, they play a central role in the cross-talk with stromal and immune cells leading...
Biochem Soc Trans (2012) 40 (4): 870–874.
Published: 20 July 2012
... AS of key genes and the initiation of prostate cancer metastasis. 1 Correspondence may be addressed to either author (email Rachel.Hagen@uwe.ac.uk or Michael.Ladomery@uwe.ac.uk ). 31 1 2012 The treatment of localized prostate cancer largely results in excellent survival outcome...
Biochem Soc Trans (2012) 40 (1): 94–100.
Published: 19 January 2012
... in cancer progression including cell transformation/oncogenesis, cell survival/apoptosis, cell migration/metastasis and tumour microenvironment neovascularization. In the present paper, we describe our research findings regarding the correlation of sphingosine kinase 1 and S1P receptor expression in tumours...
Biochem Soc Trans (2012) 40 (1): 79–84.
Published: 19 January 2012
.... In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize...
Biochem Soc Trans (2007) 35 (4): 704–706.
Published: 20 July 2007
... 1 To whom correspondence should be addressed (email jaro.sodek@utoronto.ca ) 16 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 collagen degradation confocal microscopy fibroblast membrane-type 1 matrix metalloproteinase (MT1-MMP) metastasis...
Biochem Soc Trans (2005) 33 (6): 1282–1284.
Published: 26 October 2005
... The Biochemical Society 2005 ADP-ribosylation factor-GTPase-activating protein (Arf-GAP) Arf-GAP containing Src homology domain ankyrin repeats pleckstrin homology domains 1 (ASAP1) cancer centaurin β4 development and differentiation-enhancing factor 1 (DDEF1) metastasis Mammals have six...
Biochem Soc Trans (2004) 32 (2): 355–359.
Published: 01 April 2004
... November 2003 22 October 2003 © 2004 Biochemical Society 2004 basement membrane gene expression array gene silencing metastasis phosphoinositide 3-kinase PTEN (phosphatase and tensin homologue deleted on chromosome 10) Abbreviations used: GB, GeneBloc; p110...
Biochem Soc Trans (2002) 30 (2): 217–221.
Published: 01 April 2002
... in the prophylactic treatment of diseases whose pathologies feature the formation of neovascular tissue, e.g. tumour growth and metastasis, rupture of atherosclerotic plaques and retinopathy secondary to diabetes. 1 To whom correspondence should be addressed (e-mail nickie@njce.fsnet.co.uk ). 20 11...