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Keywords: metastasis
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Articles
Biochem Soc Trans (2022) 50 (3): 1245–1257.
Published: 17 June 2022
...Ryan Lusby; Philip Dunne; Vijay K. Tiwari Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter representing the leading cause of death in cancer patients. Whilst many advances in this area have been made in recent years, the process of cancer dissemination...
Articles
Biochem Soc Trans (2021) 49 (6): 2581–2589.
Published: 02 December 2021
... implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches...
Articles
Biochem Soc Trans (2021) 49 (3): 1425–1442.
Published: 01 July 2021
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cancer Cdc42 metastasis Rho GTPases The human homologue of Saccharomyces cerevisiae CDC42 (cell division control protein 42) was identified in 1990 [ 1 , 2 ] and Cdc42 joined the Rho...
Articles
Biochem Soc Trans (2021) 49 (3): 1409–1423.
Published: 08 June 2021
...-step process, called metastasis, disseminates cancer cells primarily through vascular routes. The major steps of the metastatic cascade comprise intravasation into blood vessels, circulation as single or collectives of cells, and eventual colonization of distant organs. Herein, we consider metastasis...
Articles
Biochem Soc Trans (2020) 48 (6): 2791–2810.
Published: 01 December 2020
... ) 3 8 2020 2 11 2020 4 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cell invasion drug resistance long non-coding RNAs metastasis triple-negative breast cancer Breast cancer (BC) is a global health...
Articles
Biochem Soc Trans (2020) 48 (6): 2539–2555.
Published: 05 November 2020
... different effects on the components of the ECM driving or inhibiting augmented angiogenesis and tumour progression and tumour cell proliferation and metastasis. These effects rely on the concentration of NO within the tumour tissue, the nature of the surrounding microenvironment and the sensitivity...
Articles
Biochem Soc Trans (2019) 47 (6): 1661–1678.
Published: 22 November 2019
... Limited on behalf of the Biochemical Society 2019 cancer extracellular matrix fibrosis lysyl oxidases metastasis The amorphous material present between cells in tissues and organs was initially referred to in 1852 as ‘Grundsubstanz', translating roughly to ‘basic or fundamental substance...
Articles
Biochem Soc Trans (2019) 47 (2): 517–526.
Published: 01 April 2019
... disease metastasis sterols Oxysterols are oxidised forms of cholesterol or of its precursors ( Figure 1 ) [ 1 ]. They include 1α,25-dihydroxyvitamin D 3 , the biologically active form of vitamin D 3 , 24S-hydroxycholesterol (24S-HC), also known as cerebrosterol, the major cholesterol metabolite...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (1): 101–108.
Published: 17 December 2018
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 extracellular matrix fibroblasts metastasis tumor microenvironments Tumor progression culminating in metastasis underlies cancer mortality and it is estimated that ∼90% of all cancer...
Articles
Biochem Soc Trans (2018) 46 (6): 1517–1527.
Published: 12 November 2018
..., and promote carcinogenesis and metastasis formation. Importantly, the role of platelets in tumor immune escape has been described. These lines of evidence open the way to novel strategies to fight cancer based on the use of antiplatelet agents. In addition to their ability to release factors, platelets...
Articles
Biochem Soc Trans (2018) 46 (5): 1137–1146.
Published: 09 October 2018
... on behalf of the Biochemical Society 2018 extracellular vesicles microvesicles shedding vesicles metastasis intercellular communication tumor microenvironment Malignant transformation involves the accumulation of genetic and epigenetic alterations that manifest themselves by hijacking...
Articles
Biochem Soc Trans (2017) 45 (2): 465–475.
Published: 13 April 2017
... in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility...
Articles
Biochem Soc Trans (2017) 45 (1): 229–236.
Published: 15 February 2017
... role that CAFs play in mediating cancer cell migration and invasion through secretion of soluble factors and modification of the stromal ECM composition and the architecture ( Figure 2 ). cell migration extracellular matrix growth factors metastasis stroma tumor microenvironments...
Articles
Biochem Soc Trans (2016) 44 (5): 1305–1312.
Published: 19 October 2016
.... In this context, TRP32 (a TRX-related protein) reduces the PRLs protecting them from oxidation and, in consequence, maintaining their activity and thus contributing to cancer progression and metastasis [ 34 ]. Correspondence: Maja Köhn ( koehn@embl.de ) 2 6 2016 4 7 2016 11 7 2016...
Articles
Biochem Soc Trans (2015) 43 (4): 707–714.
Published: 03 August 2015
... cyclooxygenase 1 (COX-1) cyclooxygenase 2 (COX-2) epithelial mesenchymal transition metastasis platelets Platelets are chief effector cells in haemostasis but they are also inflammatory cells. In fact, they play a central role in the cross-talk with stromal and immune cells leading...
Articles
Biochem Soc Trans (2012) 40 (4): 870–874.
Published: 20 July 2012
... AS of key genes and the initiation of prostate cancer metastasis. 1 Correspondence may be addressed to either author (email Rachel.Hagen@uwe.ac.uk or Michael.Ladomery@uwe.ac.uk ). 31 1 2012 The treatment of localized prostate cancer largely results in excellent survival outcome...
Articles
Biochem Soc Trans (2012) 40 (1): 94–100.
Published: 19 January 2012
... in cancer progression including cell transformation/oncogenesis, cell survival/apoptosis, cell migration/metastasis and tumour microenvironment neovascularization. In the present paper, we describe our research findings regarding the correlation of sphingosine kinase 1 and S1P receptor expression in tumours...
Articles
Biochem Soc Trans (2012) 40 (1): 79–84.
Published: 19 January 2012
.... In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize...
Articles
Biochem Soc Trans (2007) 35 (4): 704–706.
Published: 20 July 2007
... reduced activity results in scar formation and fibrosis. Moreover, the ability of cancer cells to degrade fibrillar collagens is required for tumour growth and metastasis. Although collagen degradation by metalloproteinases is considered to occur extracellularly, previous studies have shown...
Articles
Biochem Soc Trans (2005) 33 (6): 1282–1284.
Published: 26 October 2005
... The Biochemical Society 2005 ADP-ribosylation factor-GTPase-activating protein (Arf-GAP) Arf-GAP containing Src homology domain ankyrin repeats pleckstrin homology domains 1 (ASAP1) cancer centaurin β4 development and differentiation-enhancing factor 1 (DDEF1) metastasis Mammals have six...
Articles
Biochem Soc Trans (2004) 32 (2): 355–359.
Published: 01 April 2004
... November 2003 22 October 2003 © 2004 Biochemical Society 2004 basement membrane gene expression array gene silencing metastasis phosphoinositide 3-kinase PTEN (phosphatase and tensin homologue deleted on chromosome 10) Abbreviations used: GB, GeneBloc; p110...
Articles
Biochem Soc Trans (2002) 30 (2): 217–221.
Published: 01 April 2002
... in the prophylactic treatment of diseases whose pathologies feature the formation of neovascular tissue, e.g. tumour growth and metastasis, rupture of atherosclerotic plaques and retinopathy secondary to diabetes. 1 To whom correspondence should be addressed (e-mail nickie@njce.fsnet.co.uk ). 20 11...
Articles
Biochem Soc Trans (2000) 28 (5): A174.
Published: 01 October 2000
...Mingcai Li © 2000 Biochemical Society 2000 fibronectin recombinant polypeptide metastasis 18th International Congress of Biochemistry and Molecular Biology: Abstracts from the 18th International Congress of Biochemistry and Molecular Biology, 16–20 July 2000, Birmingham, UK...