...Willow Rolls; Marcus D. Wilson; Duncan Sproul DNA methylation is a repressive epigenetic mark that is pervasive in mammalian genomes. It is deposited by DNA methyltransferase enzymes (DNMTs) that are canonically classified as having de novo (DNMT3A and DNMT3B) or maintenance (DNMT1) function...

... will focus on the main and most studied H3 mutations associated with cancer that have shown an effect on genome stability maintenance. Similar to lysine 27, the lysine at position 36 of histone H3 can be methylated or acetylated. Though not extensively studied in humans, H3K36ac predominantly localizes...

... of University of Melbourne in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. bivalency bivalent chromatin epigenetics gene expression and regulation histone methylation methylation Cancer can...

...Peter Sarkies DNA methylation is an epigenetic modification with a very long evolutionary history. However, DNA methylation evolves surprisingly rapidly across eukaryotes. The genome-wide distribution of methylation diversifies rapidly in different lineages, and DNA methylation is lost altogether...

...Ulduz Vafadarshamasbi; Emma Mace; David Jordan; Peter A. Crisp DNA methylation is a chromatin modification that plays an essential role in regulating gene expression and genome stability and it is typically associated with gene silencing and heterochromatin. Owing to its heritability, alterations...

... process of vegetable crops is not only regulated by environmental stimulations, but also manipulated by both genetic and epigenetic modifications. Epigenetic modifications are composed by several regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and non-coding...

... acid (RA) increase expression of Tet2 and Tet3 through binding to conserved RA-responsive elements [ 24 ]. cell differentiation epigenetics epigenomics methylation model organisms pluripotency Genome-wide profiling of 5hmC and TET1 protein binding sites have revealed enrichment...

... depend on other factors such as DNA methylation, the presence of particular histone variants and post-translational modifications of histones. Collectively, factors that modify DNA or affect its packaging and accessibility contribute to a chromatin landscape that helps to control the timely expression...

...Questa H. Karlsson; Celine Schelcher; Elizabeth Verrall; Carlo Petosa; Alison J. Sinclair EBV (Epstein–Barr virus) alternates between latency and lytic replication. During latency, the viral genome is largely silenced by host-driven methylation of CpG motifs and in the switch to the lytic cycle...

...J.M. Teodoridis; G. Strathdee; J.A. Plumb; R. Brown Aberrant methylation of CpG islands (CpG-rich regions of DNA associated with the promoters of many genes) is associated with transcriptional inactivation of genes involved in tumour development. Genes involved in key DNA damage response pathways...