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Biochem Soc Trans (2010) 38 (6): 1553–1557.
Published: 24 November 2010
... differentiation. miR - 122 is a highly liver-specific miRNA that is important in hepatitis C virus infection, cholesterol metabolism and hepatocellular carcinoma. In the present review, we discuss the effects of miR - 122 on liver physiology and pathology. Recent evidence of pathways involved in the regulation of...
Biochem Soc Trans (2008) 36 (6): 1220–1223.
Published: 19 November 2008
...Catherine L. Jopling Most metazoan miRNAs (microRNAs) bind to sites in the 3′-UTRs (untranslated regions) of mRNA targets and negatively regulate protein synthesis. The liver-specific miR - 122 , however, exerts a positive effect on HCV (hepatitis C virus) RNA levels by binding directly to a site...