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Articles

miRNAs in post-ischaemic angiogenesis and vascular remodelling

Jaimy Saif, Costanza Emanueli

Biochem Soc Trans (2014) 42 (6): 1629–1636.

https://doi.org/10.1042/BST20140263

Published: 17 November 2014

... The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis ischaemia microRNA (miRNA) stem cell vascular cell miRNAs are a family of short (20–26 nt) evolutionary conserved non-coding ssRNAs that are known to regulate or silence gene expression by repressing protein...

View articletitled, miRNAs in post-ischaemic angiogenesis and vascular remodelling

Articles

Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Usman Khalid, Timothy Bowen, Donald J. Fraser, Robert H. Jenkins

Biochem Soc Trans (2014) 42 (4): 1219–1223.

https://doi.org/10.1042/BST20140093

Published: 11 August 2014

... kidney injury cell cycle microRNA (miRNA) p53 AKI is common and its incidence in people varies somewhere between 295 and 5000 per million per year [ 25 ]. It is particularly common in critically ill patients, with reportedly more than 60% of patients who are admitted to intensive care...

View articletitled, Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Articles

The diverse roles of the eIF4A family: you are the company you keep

Wei-Ting Lu, Anna Wilczynska, Ewan Smith, Martin Bushell

Biochem Soc Trans (2014) 42 (1): 166–172.

https://doi.org/10.1042/BST20130161

Published: 23 January 2014

... for recruitment of the 43S pre-initiation complex [ 4 ]. eukaryotic initiation factor 4A (eIF4A) helicase microRNA (miRNA) translation © The Authors Journal compilation © 2014 Biochemical Society 2014 1 8 2013 1 To whom correspondence should be addressed (email mb446...

View articletitled, The diverse roles of the eIF4A family: you are the company you keep

Articles

miRNAs in development and pathogenesis of the nervous system

Jakub S. Nowak, Gracjan Michlewski

Biochem Soc Trans (2013) 41 (4): 815–820.

https://doi.org/10.1042/BST20130044

Published: 18 July 2013

... contribute towards neurodevelopmental disorders. In the present article, we review the current knowledge of the role of miRNAs in development and pathogenesis of the nervous system. 9 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) microRNA...

View articletitled, miRNAs in development and pathogenesis of the nervous system

Articles

Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy

Shyam Twayana, Ivano Legnini, Marcella Cesana, Davide Cacchiarelli, Mariangela Morlando, Irene Bozzoni

Biochem Soc Trans (2013) 41 (4): 844–849.

https://doi.org/10.1042/BST20120353

Published: 18 July 2013

... [email protected] ). 13 12 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 Duchenne muscular dystrophy long non-coding RNA (lncRNA) microRNA (miRNA) muscle differentiation The skeletal muscle system of vertebrates originates through a discrete...

View articletitled, Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy

Articles

The primary target of let-7 microRNA

Amy E. Pasquinelli

Biochem Soc Trans (2013) 41 (4): 821–824.

https://doi.org/10.1042/BST20130020

Published: 18 July 2013

... let-7 microRNA (miRNA) The founding members of the miRNA family, lin-4 and let-7 , were discovered as genes important for temporal development in the nematode Caenorhabditis elegans [ 1 , 2 ]. Well over 1000 miRNA genes are now recognized as regulators of gene expression across much...

View articletitled, The primary target of let-7 microRNA

Articles

Functional diversification of Argonautes in nematodes: an expanding universe

Amy H. Buck, Mark Blaxter

Biochem Soc Trans (2013) 41 (4): 881–886.

https://doi.org/10.1042/BST20130086

Published: 18 July 2013

.../licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Argonaute helminth microRNA (miRNA) nematode RNA interference (RNAi) small interfering RNA (siRNA) All 22G RNAs bind to members of the WAGO family...

View articletitled, Functional diversification of Argonautes in nematodes: an expanding universe

Articles

Discovery of novel small RNAs in the quest to unravel genome complexity

Adam E. Hall, Tamas Dalmay

Biochem Soc Trans (2013) 41 (4): 866–870.

https://doi.org/10.1042/BST20120347

Published: 18 July 2013

... of novel small RNAs derived from tRNAs, snoRNAs and Y RNAs, as well as the development of techniques that can reduce sequencing bias of these molecules, is slowly helping us to unveil the secrets of the genome. microRNA (miRNA) next generation sequencing sequencing bias small non-coding RNA tRNA...

View articletitled, Discovery of novel small RNAs in the quest to unravel genome complexity

Articles

Argonaute and GW182 proteins: an effective alliance in gene silencing

Janina Pfaff, Gunter Meister

Biochem Soc Trans (2013) 41 (4): 855–860.

https://doi.org/10.1042/BST20130047

Published: 18 July 2013

[email protected] ). 10 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Argonaute protein gene silencing GW182 protein microRNA (miRNA) RNA interference (RNAi) UBA domains are common sequence motifs of ~45 amino acids usually occurring...

View articletitled, Argonaute and GW182 proteins: an effective alliance in gene silencing

Articles

Cellular functions of the microprocessor

Sara Macias, Ross A. Cordiner, Javier F. Cáceres

Biochem Soc Trans (2013) 41 (4): 838–843.

https://doi.org/10.1042/BST20130011

Published: 18 July 2013

... of the microprocessor. 1 To whom correspondence should be addressed (email [email protected] ). 1 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 DGCR8 Dicer Drosha microprocessor microRNA (miRNA) small RNA miRNAs (microRNAs) are small non...

View articletitled, Cellular functions of the microprocessor

Articles

The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

Matthew Brook, Nicola K. Gray

Biochem Soc Trans (2012) 40 (4): 856–864.

https://doi.org/10.1042/BST20120100

Published: 20 July 2012

...-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cytoplasmic poly(A)-binding protein (PABP) deadenylation microRNA (miRNA) mRNA decay...

View articletitled, The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

Articles

Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat

Ananya Gupta, Emer Caffrey, Grace Callagy, Sanjeev Gupta

Biochem Soc Trans (2012) 40 (4): 752–758.

https://doi.org/10.1042/BST20110763

Published: 20 July 2012

... compilation © 2012 Biochemical Society 2012 breast cancer microRNA (miRNA) oestrogen signalling 3′-untranslated region (3′-UTR) Cancer progression frequently involves the malfunction of signalling pathways, otherwise involved in normal cellular processes of proliferation, development...

View articletitled, Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat

Articles

Analysis of urinary microRNAs in chronic kidney disease

Cristina Beltrami, Aled Clayton, Aled O. Phillips, Donald J. Fraser, Timothy Bowen

Biochem Soc Trans (2012) 40 (4): 875–879.

https://doi.org/10.1042/BST20120090

Published: 20 July 2012

... [email protected] ). 26 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 biomarker chronic kidney disease (CKD) exosome microRNA (miRNA) urine Microvesicles are formed by outward budding of the plasma membrane, while exosomes are manufactured within...

View articletitled, Analysis of urinary microRNAs in chronic kidney disease

Articles

Pleiotropy of microRNA-192 in the kidney

Robert H. Jenkins, John Martin, Aled O. Phillips, Timothy Bowen, Donald J. Fraser

Biochem Soc Trans (2012) 40 (4): 762–767.

https://doi.org/10.1042/BST20120085

Published: 20 July 2012

... in extracellular matrix deposition and cell differentiation. hepatocyte nuclear factor (HNF) microRNA (miRNA) p53 renal fibrosis transcription The miRNA family of endogenous short single-stranded RNAs down-regulate gene expression post-transcriptionally. Sequence-specific miRNA binding...

View articletitled, Pleiotropy of microRNA-192 in the kidney

Articles

Extracellular small RNAs: what, where, why?

Anna M. Hoy, Amy H. Buck

Biochem Soc Trans (2012) 40 (4): 886–890.

https://doi.org/10.1042/BST20120019

Published: 20 July 2012

.... Life Sci. 1998 54 785 794 extracellular small RNA microRNA (miRNA) RNA RNA-induced silencing complex (RISC) Mandel and Métais first described the presence of extracellular nucleic acids in human plasma in 1948 [ 1 ]. The concept of extracellular RNA emerged in a different...

View articletitled, Extracellular small RNAs: what, where, why?

Articles

The roles of miRNAs in wing imaginal disc development in Drosophila

Joseph A. Waldron, Sarah F. Newbury

Biochem Soc Trans (2012) 40 (4): 891–895.

https://doi.org/10.1042/BST20120035

Published: 20 July 2012

.... 2011 12 766 766 Drosophila microRNA (miRNA) sensory organ precursor signalling pathway Ultrabithorax wing imaginal disc development RNA UK 2012: An Independent Meeting held at The Burnside Hotel, Bowness-on-Windermere, Cumbria, U.K., 20–22 January 2012. Organized...

View articletitled, The roles of miRNAs in wing imaginal disc development in Drosophila

Articles

The role of microRNA in the response to cisplatin treatment

Ross M. Drayton

Biochem Soc Trans (2012) 40 (4): 821–825.

https://doi.org/10.1042/BST20120055

Published: 20 July 2012

... of cisplatin treatment on microRNA expression, and the ability of microRNAs to modulate cisplatin resistance. 1 email [email protected] 17 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cisplatin microRNA (miRNA) protein expression tumour...

View articletitled, The role of microRNA in the response to cisplatin treatment

Articles

MicroRNA expression profiling of human islets from individuals with and without Type 2 diabetes: promises and pitfalls

Jonathan M. Locke, Lorna W. Harries

Biochem Soc Trans (2012) 40 (4): 800–803.

https://doi.org/10.1042/BST20120049

Published: 20 July 2012

... of such an approach. 1 To whom correspondence should be addressed (email [email protected] ). 24 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 β-cell insulin secretion islet dysfunction microRNA (miRNA) Type 2 diabetes miRNAs (microRNAs...

View articletitled, MicroRNA expression profiling of human islets from individuals with and without Type 2 diabetes: promises and pitfalls

Articles

ERK5 and its role in tumour development

Pamela A. Lochhead, Rebecca Gilley, Simon J. Cook

Biochem Soc Trans (2012) 40 (1): 251–256.

https://doi.org/10.1042/BST20110663

Published: 19 January 2012

... ] as a framework, discuss the evidence for ERK5 activation by oncogenes and consider the mechanisms that regulate ERK5 protein levels. © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis cancer extracellular-signal-regulated kinase 5 (ERK5) microRNA (miRNA) migration...

View articletitled, ERK5 and its role in tumour development

Articles

Regulation of signalling by microRNAs

Roi Avraham, Yosef Yarden

Biochem Soc Trans (2012) 40 (1): 26–30.

https://doi.org/10.1042/BST20110623

Published: 19 January 2012

... mini-review, we use a set of examples to illustrate the extensive interdependence between miRNAs and signalling networks. cancer growth factor microRNA (miRNA) network tyrosine kinase Signalling 2011: a Biochemical Society Centenary Celebration: A Biochemical Society Focused Meeting held...

View articletitled, Regulation of signalling by microRNAs

Articles

Cell autonomous and systemic factors in progeria development

Fernando G. Osorio, Alejandro P. Ugalde, Guillermo Mariño, Xose S. Puente, José M.P. Freije, Carlos López-Otín

Biochem Soc Trans (2011) 39 (6): 1710–1714.

https://doi.org/10.1042/BST20110677

Published: 21 November 2011

... Society 2011 alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles in its regulation, organization and maintenance [ 1 ]. The nuclear envelope...

View articletitled, Cell autonomous and systemic factors in progeria development

Articles

SLPI and inflammatory lung disease in females

Paul J. McKiernan, Noel G. McElvaney, Catherine M. Greene

Biochem Soc Trans (2011) 39 (5): 1421–1426.

https://doi.org/10.1042/BST0391421

Published: 21 September 2011

... © The Authors Journal compilation © 2011 Biochemical Society 2011 cystic fibrosis (CF) lung disease microRNA (miRNA) oestrogen secretory leucoprotease inhibitor (SLPI) SLPI is a member of the WAP (whey acidic protein) family of proteins. These proteins share a conserved cysteine...

View articletitled, SLPI and inflammatory lung disease in females

Articles

Translation deregulation in B-cell lymphomas

Emilie Horvilleur, Lindsay A. Wilson, Anne E. Willis

Biochem Soc Trans (2010) 38 (6): 1593–1597.

https://doi.org/10.1042/BST0381593

Published: 24 November 2010

... ribosomal entry segment (IRES) microRNA (miRNA) transcription factor Lymphomas are a disparate group of neoplastic disorders of lymphoid tissues. In the West, lymphomas have an incidence of one case per 5000 people, and, of these, 95% are of B-cell origin. Within B-cell lymphomas, distinction...

View articletitled, Translation deregulation in B-cell lymphomas

Articles

Post-transcriptional gene regulation in chondrocytes

Simon R. Tew, Peter D. Clegg

Biochem Soc Trans (2010) 38 (6): 1627–1631.

https://doi.org/10.1042/BST0381627

Published: 24 November 2010

... differentiation has made it clear that miRNA-based regulation of genes is essential for chondrocyte function during development. © The Authors Journal compilation © 2010 Biochemical Society 2010 cartilage chondrocyte microRNA (miRNA) osteoarthritis post-transcriptional regulation Articular...

View articletitled, Post-transcriptional gene regulation in chondrocytes

Articles

Analysis of post-transcriptional regulation using the FunREG method

Benoît Laloo, Marion Maurel, Sandra Jalvy-Delvaille, Francis Sagliocco, Christophe F. Grosset

Biochem Soc Trans (2010) 38 (6): 1608–1614.

https://doi.org/10.1042/BST0381608

Published: 24 November 2010

... integrated and quantitative method to measure post-transcriptional regulation (FunREG) hepatocellular carcinoma microRNA (miRNA) mRNA post-transcriptional regulation RNA-binding protein Post-transcriptional regulation is a set of biological processes controlling cell transcripts from their birth...

View articletitled, Analysis of post-transcriptional regulation using the FunREG method

Articles

mRNA-specific regulation of translation by poly(A)-binding proteins

Hannah M. Burgess, Nicola K. Gray

Biochem Soc Trans (2010) 38 (6): 1517–1522.

https://doi.org/10.1042/BST0381517

Published: 24 November 2010

... first recognized. 1 To whom correspondence should be addressed (email [email protected] ). 5 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 DAZ microRNA (miRNA) mRNA-specific translational control poly(A)-binding protein (PABP) sex-lethal...

View articletitled, mRNA-specific regulation of translation by poly(A)-binding proteins

Articles

Regulation and biological function of the liver-specific miR - 122

Andrew P. Lewis, Catherine L. Jopling

Biochem Soc Trans (2010) 38 (6): 1553–1557.

https://doi.org/10.1042/BST0381553

Published: 24 November 2010

... of miR - 122 expression is also considered. 1 To whom correspondence should be addressed (email [email protected] ). 31 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cancer circadian rhythm hepatitis C virus liver microRNA...

View articletitled, Regulation and biological function of the liver-specific miR - 122

Articles

Cytoplasmic mRNA: move it, use it or lose it!

Mark J. Coldwell, Nicola K. Gray, Matthew Brook

Biochem Soc Trans (2010) 38 (6): 1495–1499.

https://doi.org/10.1042/BST0381495

Published: 24 November 2010

... 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression localization microRNA (miRNA) mRNA repression translation turnover The broad characterization of the processes of gene expression into transcription and translation does a disservice...

View articletitled, Cytoplasmic mRNA: move it, use it or lose it!

Articles

The involvement of microRNAs in Type 2 diabetes

David Ferland-McCollough, Susan E. Ozanne, Kenneth Siddle, Anne E. Willis, Martin Bushell

Biochem Soc Trans (2010) 38 (6): 1565–1570.

https://doi.org/10.1042/BST0381565

Published: 24 November 2010

... R. Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs Biol. Chem. 2008 389 305 312 β-cell dysfunction insulin resistance microRNA (miRNA) Type 2 diabetes miRNAs (microRNAs) are small 22–25-nt-long non-coding RNA...

View articletitled, The involvement of microRNAs in Type 2 diabetes

Articles

Post-transcriptional and post-translational regulation of Bcl2

Shaun Willimott, Simon D. Wagner

Biochem Soc Trans (2010) 38 (6): 1571–1575.

https://doi.org/10.1042/BST0381571

Published: 24 November 2010

...-rich elements and associated factors: are there unifying principles? Nucleic Acids Res. 2006 33 7138 7150 apoptosis AU-rich-element (ARE) Bcl2 chronic lymphocytic leukaemia (CLL) microRNA (miRNA) Bcl2 and its related family members play a central role in the regulation...

View articletitled, Post-transcriptional and post-translational regulation of Bcl2

Articles

Functions of microRNAs in Drosophila development

Christopher I. Jones, Sarah F. Newbury

Biochem Soc Trans (2010) 38 (4): 1137–1143.

https://doi.org/10.1042/BST0381137

Published: 26 July 2010

... on mRNA degradation and translation. Examples of experimentally verified targets of microRNAs in Drosophila are summarized. development Drosophila microRNA (miRNA) mRNA RNA stability RNA turnover 1 To whom correspondence should be addressed (email [email protected] ). 26...

View articletitled, Functions of microRNAs in Drosophila development

Articles

Through a generation darkly: small RNAs in the gametophyte

Robert T. Grant-Downton

Biochem Soc Trans (2010) 38 (2): 617–621.

https://doi.org/10.1042/BST0380617

Published: 22 March 2010

... processed transcripts and siRNA-associated transcripts in their nascent form, and consequently target the corresponding locus for DNA methylation and chromatin silencing. gametophyte microRNA (miRNA) short interfering RNA (siRNA) small RNA trans -acting short interfering RNA (ta-siRNA...

View articletitled, Through a generation darkly: small RNAs in the gametophyte

Articles

On track with P-bodies

Meeta Kulkarni, Sevim Ozgur, Georg Stoecklin

Biochem Soc Trans (2010) 38 (1): 242–251.

https://doi.org/10.1042/BST0380242

Published: 19 January 2010

... ]. Rather than being permanently associated with P-bodies, it appears that most NMD factors cycle through P-bodies as NMD substrates are delivered for degradation. AU-rich element deadenylation decapping GW-body microRNA (miRNA) mRNA degradation P-bodies are small cytoplasmic foci...

View articletitled, On track with P-bodies

Includes: Multimedia, Supplementary data

Articles

microRNA in erythrocytes

Andrew J. Hamilton

Biochem Soc Trans (2010) 38 (1): 229–231.

https://doi.org/10.1042/BST0380229

Published: 19 January 2010

... microRNA in these cells. erythrocyte microRNA (miRNA) ribosome Ro translation Y RNA Gene Expression in Development and Disease: 13th Tenovus-Scotland Symposium, an Independent Meeting held at University of Glasgow, Glasgow, U.K., 16–17 April 2009. Organized and Edited by Sheila Graham...

View articletitled, microRNA in erythrocytes

Articles

Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

Angela Bithell, Rory Johnson, Noel J. Buckley

Biochem Soc Trans (2009) 37 (6): 1270–1275.

https://doi.org/10.1042/BST0371270

Published: 19 November 2009

... development had increased REST occupancy in human HD samples [ 10 ]. 27 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 brain-derived neurotrophic factor (BDNF) Huntingtin Huntington's disease (HD) microRNA (miRNA) neuronal dysfunction repressor element 1...

View articletitled, Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

Articles

High-throughput sequencing methods to study neuronal RNA–protein interactions

Jernej Ule

Biochem Soc Trans (2009) 37 (6): 1278–1280.

https://doi.org/10.1042/BST0371278

Published: 19 November 2009

... (CLIP) microRNA (miRNA) ribosome profiling synaptic plasticity UV-cross-linking Diverse post-transcriptional mechanisms allow a cell to precisely control the proteins to be synthesized at different cellular locations. The role of RNA regulation is particularly apparent in its contribution...

View articletitled, High-throughput sequencing methods to study neuronal RNA–protein interactions

Articles

miR-21 as a key regulator of oncogenic processes

S. Duygu Selcuklu, Mark T.A. Donoghue, Charles Spillane

Biochem Soc Trans (2009) 37 (4): 918–925.

https://doi.org/10.1042/BST0370918

Published: 22 July 2009

... are listed for the human genome (miRBase: Database Release 12.0) [ 5 ]. cancer gene regulation microRNA (miRNA) miR-21 oncomir © The Authors Journal compilation © 2009 Biochemical Society 2009 27 1 2009 1 To whom correspondence should be addressed (email c.spillane...

View articletitled, miR-21 as a key regulator of oncogenic processes

Articles

Regulation of B-cell differentiation by microRNAs and RNA-binding proteins

Alexander Ademokun, Martin Turner

Biochem Soc Trans (2008) 36 (6): 1191–1193.

https://doi.org/10.1042/BST0361191

Published: 19 November 2008

... 6939 B-cell cytokine microRNA (miRNA) RNA-binding protein T-cell tristetraprolin (TTP) Post-transcriptional regulation controls the abundance, turnover and translation of mRNA and offers the capacity to integrate signal transduction events with very rapid changes in gene...

View articletitled, Regulation of B-cell differentiation by microRNAs and RNA-binding proteins

Articles

Identification of genes targeted by microRNAs

Tamas Dalmay

Biochem Soc Trans (2008) 36 (6): 1194–1196.

https://doi.org/10.1042/BST0361194

Published: 19 November 2008

... Argonaute protein complexes RNA Biol. 2007 4 76 84 1 email [email protected] 9 9 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 antimir antagomir microRNA (miRNA) RNA-induced silencing complex (RISC) target prediction program...

View articletitled, Identification of genes targeted by microRNAs

Articles

How do microRNAs regulate gene expression?

Ian G. Cannell, Yi Wen Kong, Martin Bushell

Biochem Soc Trans (2008) 36 (6): 1224–1231.

https://doi.org/10.1042/BST0361224

Published: 19 November 2008

... their discovery much progress has been made in understanding their biogenesis and target site recognition within their target mRNAs [ 1 , 2 ]. However, it is still unclear how miRNAs repress gene expression. gene expression in vitro -transcribed RNA microRNA (miRNA) polysomes protein synthesis...

View articletitled, How do microRNAs regulate gene expression?

Articles

Role of microRNAs in haemopoiesis, heart hypertrophy and cancer

Laura Fontana, Antonio Sorrentino, Gianluigi Condorelli, Cesare Peschle

Biochem Soc Trans (2008) 36 (6): 1206–1210.

https://doi.org/10.1042/BST0361206

Published: 19 November 2008

... embryos [ 10 ]. cancer haemopoiesis heart hypertrophy microRNA (miRNA) miRNAs (microRNAs) are a rapidly expanding class of short (∼22 nt) single-stranded non-coding RNAs [ 1 , 2 ]. miRNAs can be encoded in independent transcription units, in polycistronic clusters or within the introns...

View articletitled, Role of microRNAs in haemopoiesis, heart hypertrophy and cancer

Articles

Role of miRNA - 146a in the regulation of the innate immune response and cancer

Andrew E. Williams, Mark M. Perry, Sterghios A. Moschos, Hanna M. Larner-Svensson, Mark A. Lindsay

Biochem Soc Trans (2008) 36 (6): 1211–1215.

https://doi.org/10.1042/BST0361211

Published: 19 November 2008

... the evidence for a role of miR - 146a in innate immunity and cancer and assess whether changes in miR - 146a might link these two biological responses. cancer inflammation innate immune response lung microRNA (miRNA) miR - 146a miRNA (microRNA)-mediated RNA interference is a novel mechanism...

View articletitled, Role of miRNA - 146a in the regulation of the innate immune response and cancer

Articles

Targeting of microRNAs for therapeutics

Jan Stenvang, Morten Lindow, Sakari Kauppinen

Biochem Soc Trans (2008) 36 (6): 1197–1200.

https://doi.org/10.1042/BST0361197

Published: 19 November 2008

... and high stability in blood and tissues in vivo . Recent reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics. MicroRNAs (miRNAs) comprise...

View articletitled, Targeting of microRNAs for therapeutics

Articles

Role of microRNAs in myeloid differentiation

Alessandro Fatica, Alessandro Rosa, Monica Ballarino, Maria Laura De Marchis, Kasper D. Rasmussen, Irene Bozzoni

Biochem Soc Trans (2008) 36 (6): 1201–1205.

https://doi.org/10.1042/BST0361201

Published: 19 November 2008

... (C/EBP) haemopoiesis microRNA (miRNA) myelopoiesis The mechanism by which ATRA regulates miRNA expression is largely uncharacterized. We hypothesized that miRNAs expression could be regulated in part by ATRA-modulated transcription factors. In fact, we demonstrated that miR - 223 is induced...

View articletitled, Role of microRNAs in myeloid differentiation

Articles

Target site effects in the RNA interference and microRNA pathways

Gregor Obernosterer, Hakim Tafer, Javier Martinez

Biochem Soc Trans (2008) 36 (6): 1216–1219.

https://doi.org/10.1042/BST0361216

Published: 19 November 2008

... Biochemical Society 2008 cleavage microRNA (miRNA) RNA-induced silencing complex (RISC) RNA cleavage small interfering RNA (siRNA) target site accessibility Over the past few years RNAi (RNA interference) has become an essential tool to investigate gene function by introducing siRNAs (small...

View articletitled, Target site effects in the RNA interference and microRNA pathways

Articles

Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

A. Abderrahmani, V. Plaisance, P. Lovis, R. Regazzi

Biochem Soc Trans (2006) 34 (5): 696–700.

https://doi.org/10.1042/BST0340696

Published: 25 October 2006

... (email [email protected] ). 16 6 2006 © 2006 The Biochemical Society 2006 diabetes mellitus exocytotic apparatus inducible cAMP early repressor (ICER) microRNA (miRNA) Rab transcription factor CRE cAMP-response element CREM CRE modulator ICER...

View articletitled, Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

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