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Keywords: microtubule-associated protein tau
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Articles

Modelling early responses to neurodegenerative mutations in mice

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Jonathan Gilley, Robert Adalbert, Michael P. Coleman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 933–938.
https://doi.org/10.1042/BST0390933
Published: 20 July 2011
... The Authors Journal compilation © 2011 Biochemical Society 2011 aging Alzheimer's disease axonal transport frontotemporal dementia knockin mouse microtubule-associated protein tau The mouse is the most frequently used mammal for modelling late-onset human neurodegenerative disease...
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Articles

A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2 , SNCA and MAPT BAC-transgenic mice

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Sara J. Johnson, Richard Wade-Martins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 862–867.
https://doi.org/10.1042/BST0390862
Published: 20 July 2011
... results of recent studies investigating PD (Parkinson's disease) and tauopathies using BAC-transgenic mice carrying either the LRRK2 (leucine-rich repeat kinase 2), α-synuclein ( SNCA ) or MAPT (microtubule-associated protein tau) genes. In all lines, expression of the WT (wild-type) gene resulted...
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