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Keywords: mitochondria
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Biochem Soc Trans (2024) BST20230189.
Published: 25 March 2024
... for exploring Complex I inhibitors in cancer treatment, even when OXPHOS functionality is already compromised. Figure 1. Sources of oxidized ubiquinone (UQ) within mitochondria. Solid lines indicate the main pathways. Gray dashed lines indicate minor, theoretical or impeded pathways as described...
Biochem Soc Trans (2024) 52 (1): 65–74.
Published: 22 February 2024
... levels of superoxide, hydrogen peroxide and other ROS in a potentially vicious cycle is both causative and a consequence of mitochondrial dysfunction. Mitochondrial dysfunction may be ameliorated by molecules with antioxidant capacities that accumulate in mitochondria such as carotenoids. However...
Biochem Soc Trans (2024) 52 (1): 99–110.
Published: 30 January 2024
...Jiajia He; Ke Liu; Chuanhai Fu Mitochondria are the powerhouse of the cell. They undergo fission and fusion to maintain cellular homeostasis. In this review, we explore the intricate regulation of mitochondrial fission at various levels, including the protein level, the post-translational...
Biochem Soc Trans (2023) 51 (6): 2117–2126.
Published: 21 November 2023
...Maryam Mukhtar; Krutika Thakkur; Agnieszka Chacinska; Piotr Bragoszewski Mitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex...
Biochem Soc Trans (2023) 51 (6): 2029–2040.
Published: 17 November 2023
... are fundamentally important to robust plant growth and defense. Chloroplasts, mitochondria, and peroxisomes are essential organelles in plants that function independently and coordinately during energy metabolism and other key metabolic processes. In response to developmental and environmental stimuli, these energy...
Includes: Multimedia, Supplementary data
Biochem Soc Trans (2023) 51 (6): 2153–2161.
Published: 13 November 2023
... are structurally similar to those found in ATP, and the high abundance of polyP in mammalian mitochondria, suggest that polyP could be involved in the regulation of the physiology of the organelle, especially in the energy metabolism. In fact, the scientific literature shows an unequivocal role for polyP not only...
Biochem Soc Trans (2023) 51 (5): 1947–1956.
Published: 16 October 2023
... cytosolic polyP accumulation. We reviewed the literature on polyP in the mitochondria from the perspective of its endosymbiotic origin from bacteria, highlighting how mitochondria could possess a polyP physiology reminiscent of their ‘bacterial’ beginning that is not yet investigated. Finally, we emphasised...
Biochem Soc Trans (2023) 51 (5): 1765–1776.
Published: 22 September 2023
...). Published by Portland Press Limited on behalf of the Biochemical Society 2023 acyl remodeling glycerophospholipids membrane traffic metabolism mitochondria signaling Phosphatidylinositol (PI) and cardiolipin (CL) are two glycerophospholipids (GPLs) that have distinct structure, function...
Biochem Soc Trans (2023) 51 (5): 1811–1846.
Published: 01 September 2023
.... Unfortunately, mitophagy declines with age. Many age-associated diseases, including Alzheimer's and Parkinson's, are characterized by the accumulation of damaged mitochondria and oxidative damage. Therefore, activating the mitophagy process with small molecules is an emerging strategy for treating multiple...
Biochem Soc Trans (2023) 51 (2): 735–745.
Published: 04 April 2023
... cytokines, both at the tissue and systemic levels. Age-related inflammation can be mainly driven by self-molecules with immunostimulant properties, named Damage/death Associated Molecular Patterns (DAMPs), released by dead, dying, injured cells or aged cells. Mitochondria are an important source of DAMPs...
Biochem Soc Trans (2023) 51 (2): 665–673.
Published: 24 March 2023
... BY) . calcium signaling mitochondria mitochondrial calcium uniporter mitochondrial signaling Mitochondrial calcium (Ca 2+ ) uptake was first observed as an in vitro phenomenon in the early 1960s [ 1 , 2 ]. It was quickly recognized as an important regulator of mitochondrial bioenergetics through Ca...
Biochem Soc Trans (2023) 51 (2): 571–577.
Published: 09 March 2023
...Margret Helene Bülow; Julia Sellin The study of endoplasmic reticulum (ER)-mitochondria communication is a vast and expanding field with many novel developments in the past few years. In this mini-review, we focus on several recent publications that identify novel functions of tether complexes...
Biochem Soc Trans (2023) 51 (1): 457–472.
Published: 23 February 2023
... is released may enable the development of drugs to specifically target or inhibit mtDNA release in different disease settings. Eukaryotic cells contain a highly elaborate, organellar system ensuring cellular homeostasis. DNA resides in two distinct organelles, nuclei and mitochondria. The presence of DNA...
Biochem Soc Trans (2023) 51 (1): 173–182.
Published: 23 January 2023
...Heather M. Wilkins Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria...
Biochem Soc Trans (2022) 50 (5): 1389–1402.
Published: 28 October 2022
... The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Mitochondria-associated ER membranes (MAMs) serve as a classic example of an inter-organelle...
Biochem Soc Trans (2022) 50 (3): 1119–1132.
Published: 19 May 2022
... be achieved through proteomic turnover or modular degradation. In this review, we present multiple protein degradation pathways in plant mitochondria. Specifically, we focus on the intricate turnover of OXPHOS subunits, prior to protein import via cytosolic proteasomal degradation and post import and assembly...
Biochem Soc Trans (2022) 50 (2): 783–797.
Published: 21 March 2022
... in mitophagy, the process of selective autophagic elimination of damaged mitochondria. Impaired mitophagy has been associated with sporadic Parkinson's and agents that damage mitochondria are known to induce Parkinson's-like motor symptoms in humans and animal models. Thus, modulating mitophagy pathways may...
Biochem Soc Trans (2021) 49 (6): 2929–2939.
Published: 09 December 2021
...Shona A. Mookerjee; Akos A. Gerencser; Mark A. Watson; Martin D. Brand Oxidation of succinate by mitochondria can generate a higher protonmotive force (pmf) than can oxidation of NADH-linked substrates. Fundamentally, this is because of differences in redox potentials and gearing. Biology adds...
Biochem Soc Trans (2021) 49 (6): 2807–2819.
Published: 23 November 2021
...Golam M. Uddin; Rafa Abbas; Timothy E. Shutt The dynamic processes of mitochondrial fusion and fission determine the shape of mitochondria, which can range from individual fragments to a hyperfused network, and influence mitochondrial function. Changes in mitochondrial shape can occur rapidly...
Biochem Soc Trans (2021) 49 (5): 2199–2210.
Published: 19 October 2021
...Nicholas T. Ktistakis The pathway of mitochondrial-specific autophagy (mitophagy, defined here as the specific elimination of mitochondria following distinct mitochondrial injuries or developmental/metabolic alterations) is important in health and disease. This review will be focussed...
Biochem Soc Trans (2021) 49 (2): 715–726.
Published: 26 March 2021
... changes in insulin-binding affinity and ameliorating actions of weak organic acids on insulin resistance via their characteristics as bases after absorption into the body even with sour taste at the tongue. glycolysis insulin interstitial fluid pH mitochondria TCA cycle type 2 diabetes mellitus...
Biochem Soc Trans (2021) 49 (1): 17–27.
Published: 18 February 2021
...Hasan Al-Habib; Margaret Ashcroft Mitochondria are pivotal for normal cellular physiology, as they perform a crucial role in diverse cellular functions and processes, including respiration and the regulation of bioenergetic and biosynthetic pathways, as well as regulating cellular signalling...
Biochem Soc Trans (2021) 49 (1): 485–494.
Published: 13 January 2021
... pressure overload, which is related to changes in the mitochondria and calcium overload. However, certain studies have drawn opposing conclusions, including the mitigation of ischemia/reperfusion injury via inhibition of VCP/p97 ATPase activity. Nevertheless, these emerging studies shed light on the role...
Biochem Soc Trans (2020) 48 (6): 2565–2578.
Published: 27 November 2020
...Tatsuhisa Tsuboi; Jordan Leff; Brian M. Zid In fluctuating environmental conditions, organisms must modulate their bioenergetic production in order to maintain cellular homeostasis for optimal fitness. Mitochondria are hubs for metabolite and energy generation. Mitochondria are also highly dynamic...
Biochem Soc Trans (2020) 48 (3): 799–811.
Published: 29 June 2020
... cAMP cardiopulmonary diesel exhaust particles mitochondria nanodomains Air pollution is related to several cardiopulmonary disorders, such as ischemic heart disease, cardiac dysrhythmias, heart failure, cerebrovascular disease, stroke, asthma, chronic obstructive pulmonary disease (COPD...
Biochem Soc Trans (2020) 48 (3): 1035–1046.
Published: 03 June 2020
... of the proteins inserted into those membranes. They are synthesized by two main pathways, the so-called eukaryotic pathway, exclusively found in mitochondria, and the prokaryotic pathway, present in most bacteria and archaea. In the prokaryotic pathway, the first and the third reactions are catalyzed...
Includes: Supplementary data
Biochem Soc Trans (2020) 48 (3): 993–1004.
Published: 26 May 2020
...Anna L. Duncan Monolysocardiolipin (MLCL) is a three-tailed variant of cardiolipin (CL), the signature lipid of mitochondria. MLCL is not normally found in healthy tissue but accumulates in mitochondria of people with Barth syndrome (BTHS), with an overall increase in the MLCL:CL ratio. The reason...
Biochem Soc Trans (2020) 48 (2): 621–629.
Published: 20 April 2020
... agreement with CAUL. mitochondria oxidative phosphorylation structural biology Mitochondria produce the vast majority of the ATP used by eukaryotic life and as such have been frequently labelled the ‘powerhouse of the cell’ by popular culture and academics alike [ 1 ]. Production of ATP...
Biochem Soc Trans (2020) 48 (2): 631–644.
Published: 27 March 2020
... and cellular metabolic and pathogenic conditions. Under conditions of cellular stress, there is a disruption of this fission and fusion balance and mitochondria undergo either increased fusion, forming a hyperfused meshwork or excessive fission to counteract stress and remove damaged mitochondria via mitophagy...
Biochem Soc Trans (2020) 48 (1): 165–177.
Published: 03 February 2020
.... This review will focus on the relationship of a particular membrane microdomain — caveolae — with mitochondria and the particular implication of this to physiology and pathophysiology. Correspondence: Hemal H. Patel ( hepatel@ucsd.edu ) 21 11 2019 9 1 2020 10 1 2020 © 2020...
Biochem Soc Trans (2019) 47 (6): 1963–1969.
Published: 26 November 2019
...Andrey Y. Abramov; Plamena R. Angelova Mitochondria control vitally important functions in cells, including energy production, cell signalling and regulation of cell death. Considering this, any alteration in mitochondrial metabolism would lead to cellular dysfunction and the development...
Biochem Soc Trans (2019) 47 (5): 1269–1277.
Published: 31 October 2019
...Toshiya Endo; Haruka Sakaue Mitochondria are essential eukaryotic organelles responsible for primary cellular energy production. Biogenesis, maintenance, and functions of mitochondria require correct assembly of resident proteins and lipids, which require their transport into and within...
Biochem Soc Trans (2019) 47 (5): 1429–1436.
Published: 24 September 2019
...Rawaa A. Z. Al-Faresi; Robert. N. Lightowlers; Zofia M. A. Chrzanowska-Lightowlers Mitochondria are ubiquitous organelles present in the cytoplasm of all nucleated eukaryotic cells. These organelles are described as arising from a common ancestor but a comparison of numerous aspects of mitochondria...
Biochem Soc Trans (2019) 47 (5): 1367–1382.
Published: 04 September 2019
... ) 25 6 2019 6 8 2019 8 8 2019 © 2019 The Author(s) 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . heteroplasmy mitochondria mtDNA...
Biochem Soc Trans (2018) 46 (5): 1225–1238.
Published: 04 October 2018
...Thomas Daniel Jackson; Catherine Sarah Palmer; Diana Stojanovski Mitochondria are essential organelles which perform complex and varied functions within eukaryotic cells. Maintenance of mitochondrial health and functionality is thus a key cellular priority and relies on the organelle's extensive...
Biochem Soc Trans (2018) 46 (4): 829–842.
Published: 09 July 2018
... to a toxin gain- or loss-of-function contributing to the phenotype observed in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and frontotemporal dementia. Misfolded proteins can adversely affect mitochondria, and post-mitotic neurones are especially sensitive to metabolic dysfunction...
Biochem Soc Trans (2018) 46 (3): 599–607.
Published: 20 April 2018
... mitochondria muscle metabolism As terrestrial altitude increases, barometric pressure falls while the atmospheric proportion of oxygen remains constant at 21%. Accordingly, the partial pressure of oxygen decreases at high altitude, giving rise to hypobaric hypoxia. For humans ascending to altitude...
Biochem Soc Trans (2018) 46 (2): 437–452.
Published: 27 March 2018
...Francesca Giordano Mitochondria are highly dynamic organelles involved in various cellular processes such as energy production, regulation of calcium homeostasis, lipid trafficking, and apoptosis. To fulfill all these functions and preserve their morphology and dynamic behavior, mitochondria need...
Biochem Soc Trans (2017) 45 (5): 1045–1052.
Published: 04 August 2017
...Angelika B. Harbauer Neurons are post-mitotic cells that must function throughout the life of an organism. The high energetic requirements and Ca 2+ spikes of synaptic transmission place a burden on neuronal mitochondria. The removal of older mitochondria and the replenishment of the functional...
Biochem Soc Trans (2017) 45 (4): 1025–1033.
Published: 21 July 2017
... features including the involvement of mitochondria in the mechanism of pathology and misfolding and the accumulation of abnormally aggregated proteins. Neurotoxicity of aggregated β-amyloid, tau, α-synuclein and huntingtin is linked to the effects of these proteins on mitochondria. All these misfolded...
Biochem Soc Trans (2017) 45 (2): 371–379.
Published: 13 April 2017
...) allows for precise and local control of second messenger signaling events. Here, we will discuss how pseudoenzymes form ‘pseudoscaffolds’ and compare and contrast this compartment-specific regulatory role with the signal organization properties of AKAPs. The mitochondria will be the focus of this review...
Biochem Soc Trans (2017) 45 (2): 513–529.
Published: 13 April 2017
... 2 2017 21 2 2017 © 2017 The Author(s) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . DNA replication and recombination mitochondria...
Biochem Soc Trans (2017) 45 (2): 477–488.
Published: 13 April 2017
...Yael Elbaz-Alon Membrane contact sites (MCSs) are areas of close apposition between the membranes of two different organelles that enable non-vesicular transfer of ions and lipids. Recent studies reveal that mitochondria maintain contact sites with organelles other than the endoplasmic reticulum...
Biochem Soc Trans (2017) 45 (1): 269–274.
Published: 15 February 2017
... and targets of the pathway. In recent years, it has become evident that mitochondria represent sites of compartmentalised cAMP signalling. However, the exact location and the molecular composition of distinct mitochondria signalosomes and their function remain largely unknown. In this review, we focus...
Biochem Soc Trans (2016) 44 (6): 1725–1735.
Published: 02 December 2016
...Hakjoo Lee; Yisang Yoon Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood...
Biochem Soc Trans (2016) 44 (6): 1617–1623.
Published: 02 December 2016
... of LRRK2 are numerous and depend on the state of the cell. LRRK2 is widely expressed in many tissues and cell types. Most is present in the cytosol with a proportion found in organelles, such as the mitochondria, Golgi, endosomes and lysosomes. There are multiple strands of evidence, indicating that LRRK2...
Biochem Soc Trans (2016) 44 (5): 1483–1490.
Published: 19 October 2016
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models therapeutics Beside mtDNA-encoded proteins, the vast majority of the ∼1500 polypeptides forming...
Biochem Soc Trans (2016) 44 (5): 1475–1482.
Published: 19 October 2016
...Shiri Levy; Gadi Schuster Mitochondria have their own gene expression machinery and the relative abundance of RNA products in these organelles in animals is mostly dictated by their rate of degradation. The molecular mechanisms regulating the differential accumulation of the transcripts...