... mitochondrial dysfunction TCA cycle Cancer cells adaptively rewire metabolic pathways to sustain unlimited proliferation, promote motility/metastatization, and face harsh microenvironmental conditions including nutrient/oxygen limitations and host immune surveillance [ 1 ]. For this purpose, a tight co...

... mechanisms, including mitochondrial dysfunction, in several major neuropsychiatric and neurodegenerative diseases. Epilepsy is one of the most common neurological disorders worldwide and affects approximately 1 in 103 people in the U.K. (Epilepsy Research U.K.). It is characterised by recurrent...

... ]. Correspondence: Erika Fernández-Vizarra ( [email protected] ) * Present address: Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, U.S.A. 30 1 2024 12 3 2024 14 3 2024 complex IV mitochondrial dysfunction reactive oxygen...

... © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 electron transport chain MCU mitochondrial dysfunction mitochondrial permeability transition pores NCLX oxidative phosphorylation Ca 2+ is a ubiquitous divalent ion essential...

...). Modeling these disorders is revealing how mitochondrial dysfunction may drive ALS and PD pathogenesis by a gain of function mechanism, driven by protein misfolding of CHCHD2 and CHCHD10 into toxic species. It is also laying the groundwork for precision therapy of CHCHD2/CHCHD10-related neurodegeneration...

... that drug-induced mitochondrial dysfunction plays an important role in a variety of drug-induced organ toxicities [ 11 , 12 ]. Due to the role of mitochondrial dysfunction in the onset of ADRs, it has been hypothesised that variation in mtDNA may underpin some of the idiosyncrasies associated with drug...

... Press Limited on behalf of the Biochemical Society 2019 antioxidants hydrogen peroxide mitochondria mitochondrial dysfunction reactive oxygen species superoxide There is an ever-increasing literature that associates mitochondrial reactive oxygen species (ROS) in either a causal...

... of several pathways can contribute to the overall effect, including the inhibition of translation, which results in reduced energetic demand, and stress responses as well as the activation of autophagy. bypass therapy gene therapy mitochondrial biogenesis mitochondrial dysfunction rapamycin...

... on behalf of the Biochemical Society 2018 Alzheimer's disease mitochondrial dysfunction Parkinson's disease therapeutics The mitochondria are essential organelles to all eukaryotic cells. They are a highly dynamic double membrane-bound structure, containing their own circular, double...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics cardiac hypertrophy metabolism mitochondrial dysfunction sodium Cardiovascular disease is the leading cause of mortality worldwide with its incidence projected to rise significantly in the immediate...

... 2016 © 2016 The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models...

... alcohol (CHANA) cyclophilin D (CypD) intracellular amyloid β-peptide (intracellular Aβ) mitochondrial dysfunction A link between mitochondrial dysfunction and neurodegenerative conditions, such as AD (Alzheimer's disease), has long been suggested to exist. Observations of altered cerebral blood...

... of the major evidence surrounding mitochondrial DNA mutations leading to mitochondrial dysfunction in neurodegenerative disease and discuss their possible role in neurodegeneration. 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 1 To whom correspondence should...