... pathology resulting in excitotoxicity or oxidative stress. Interaction of the calcium and ROS is essential to trigger opening of mitochondrial permeability transition pore — the initial step of apoptosis, Ca 2+ and ROS-induced oxidative stress involved in necrosis and ferroptosis. Here we review the role...

... ]. Complex isolated from rat liver mitochondria forms high conductance channels with properties similar to the mitochondrial permeability transition pore (mPTP) [ 23 ]. Notably, in these experiments, isolation of the complex was performed from the mitochondria preincubated with calcium to mimic conditions...

.... , Carrer , A. , Franchin , C. , Arrigoni , G. , Jiko , C. et al. ( 2019 ) Purified F-ATP synthase forms a Ca 2+ -dependent high-conductance channel matching the mitochondrial permeability transition pore . Nat. Commun. 10 , 4341 10.1038/s41467-019-12331-1 110 Neginskaya...