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Keywords: mitochondrial replacement therapy
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Alan Diot, Eszter Dombi, Tiffany Lodge, Chunyan Liao, Karl Morten, Janet Carver, Dagan Wells, Tim Child, Iain G. Johnston, Suzannah Williams, Joanna Poulton
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1091–1100.
Published: 15 August 2016
... generations. In ‘mitochondrial replacement therapy’ (MRT), damaged mitochondria are replaced with healthy ones in early human development, using nuclear transfer. We are developing non-invasive alternatives, notably activating autophagy, a cellular quality control mechanism, in which damaged cellular...
