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Keywords: mitochondrion
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Articles
Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
... be critical for tissue homoeostasis. However, the underlying regulatory mechanisms appear to be multiple and this article summarizes current aspects by which MnSOD can regulate carcinogenesis under various conditions. inflammation liver failure manganese superoxide dismutase mitochondrion reactive...
Articles
Biochem Soc Trans (2014) 42 (4): 1069–1074.
Published: 11 August 2014
...-besta.it ). 22 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 brain coenzyme A (CoA) inborn error of metabolism mitochondrion neurodegeneration pantothenate kinase 2 (PANK2) To date, ten genes have been associated with specific forms of NBIA...
Articles
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
... chemotherapy lymphoma metabolism mitochondrion redox homoeostasis Cancer cells frequently function with a more oxidized redox environment [ 1 ]. An expanded set of cancer hallmarks was proposed by Luo et al. in 2009 [ 2 ] and includes oxidative stress. Indications of altered cellular redox...
Articles
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling The IMS is the second aqueous compartment of mitochondria (the other being the matrix). The IMS is defined by the OMM and IMM and has emerged as a significant regulatory domain in the co-ordination...
Articles
Biochem Soc Trans (2014) 42 (2): 231–238.
Published: 20 March 2014
... for activities of daily living). These defects in functional exercise capacity have implications for day-to-day life and longevity. cAMP-response-element-binding protein (CREB) cardiovascular disease diabetes exercise mitochondrion nitric oxide synthase (NOS) CREB content and nuclear...
Articles
Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
Articles
Biochem Soc Trans (2013) 41 (6): 1503–1508.
Published: 20 November 2013
... Biochemical Society 2013 autophagy dopaminergic neuron induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) mitochondrion Parkinson’s disease (PD) Autophagy is the process by which cells degrade damaged proteins and organelles, and is further induced by starvation...
Articles
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
... mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking The brain is only 2% of the body's weight, but it uses 20% of the body's resting energy production. This high level of energy consumption is mainly used to reverse the ion fluxes that underlie action potential signalling...
Articles
Biochem Soc Trans (2013) 41 (5): 1335–1341.
Published: 23 September 2013
... protein) mitochondrion oxidative phosphorylation complex (OXPHOS complex) Reorganization of the eukaryotic cell after the endosymbiotic event triggered an increase in complexity of the mitochondrial OXPHOS complexes and metabolic pathways. LYRM proteins contribute to the higher complexity...
Articles
Biochem Soc Trans (2013) 41 (5): 1227–1234.
Published: 23 September 2013
... mitochondrion Cryo-ET is a relatively new technique that can image cellular features in three dimensions as well as the distribution and, in favourable cases, the structure of protein complexes in situ . The technique has been used to investigate biological structures ranging from isolated protein...
Articles
Biochem Soc Trans (2013) 41 (5): 1272–1279.
Published: 23 September 2013
... 2013 © 2013 The Authors 2013 accessory subunit assembly mitochondrion NADH:ubiquinone oxidoreductase respiratory complex I Figure 1 Architecture of mitochondrial complex I The matrix arm comprises the N-module (yellow) and the Q-module (orange). Iron–sulfur clusters (blue...
Articles
Biochem Soc Trans (2013) 41 (2): 620–624.
Published: 21 March 2013
... ]. Interestingly, as remarked in [ 15 ], a very reasonable estimate of the size of tight protein knots can be obtained by relating to the ideal tight knots in perfect ropes [ 20 ]. These are uniquely characterized by their length/diameter ratio: (2) conformational change knot mitochondrion molecular...
Articles
Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
... kinase) pathway is induced by increased oxidative stress and JNK translocation to the mitochondrion results in impairment of energy metabolism. Moreover, IIS and JNK signalling interact with and antagonize each other. This review focuses on functional outcomes of a metabolic triad that entails the co...
Articles
Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
.... Organized by Giovanni Mann (King's College London, U.K.) and Michael Murphy (MRC Mitochondrial Biology Unit, Cambridge, U.K.). Edited by Michael Murphy. γ-glutamylcysteine glutathione mitochondrion reactive oxygen species One of the most efficient forms for energy production in aerobic...
Articles
Biochem Soc Trans (2013) 41 (1): 1–16.
Published: 29 January 2013
... chloroplast energy cost mitochondrion protonmotive force rotor stator “From the earliest times breathing and the warmth of the body were recognized as the chief manifestations of life”. So wrote David Keilin at the beginning of the first chapter of his book The History of Cell Respiration...
Articles
Biochem Soc Trans (2013) 41 (1): 111–117.
Published: 29 January 2013
... of the mitochondrion and nucleus were likely to be on more equal terms in regulating cell function than commonly contemplated today. Interpretation and designing experiments directed at understanding how mitochondrial–nuclear functionality evolved will undoubtedly lead to greater understanding of disease pathology...
Articles
Biochem Soc Trans (2013) 41 (1): 124–126.
Published: 29 January 2013
...), in the Crabtree effect. 1 To whom correspondence should be addressed (email [email protected] ). 24 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer Crabtree effect extracellular-signal-regulated kinase 5 (ERK5) mitochondrion p90...
Articles
Biochem Soc Trans (2012) 40 (6): 1426–1432.
Published: 21 November 2012
... functions of Rabs on the ER (endoplasmic reticulum). 1 To whom correspondence should be addressed (email [email protected] ). 27 6 2012 © 2012 The Authors Journal 2012 endoplasmic reticulum (ER) Golgi complex GTPase mitochondria-associated membrane (MAM) mitochondrion...
Articles
Biochem Soc Trans (2012) 40 (4): 865–869.
Published: 20 July 2012
... of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion. 1 To whom correspondence should be addressed (email [email protected] ). 26...
Articles
Biochem Soc Trans (2012) 40 (2): 445–450.
Published: 21 March 2012
... ). 1 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cardiolipin cytosol endoplasmic reticulum (ER) endoplasmic reticulum–mitochondria encounter structure (ERMES) lipid binding mitochondrion The eukaryotic cell is a highly complex entity that carries...
Articles
Biochem Soc Trans (2012) 40 (1): 158–167.
Published: 19 January 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium uptake local calcium signalling mitochondrion store organization tether To explore the consequences of local mitochondrial Ca 2+ uptake on global Ca 2+ signals, mitochondrial function throughout the cell...
Articles
Biochem Soc Trans (2011) 39 (5): 1482–1487.
Published: 21 September 2011
... to either of these authors (email [email protected] and [email protected] ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...
Articles
Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email [email protected] 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...
Articles
Biochem Soc Trans (2011) 39 (5): 1221–1225.
Published: 21 September 2011
... dichlorodihydrofluorescein or dihydrorhodamine. 1 email [email protected] . 15 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide...
Articles
Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email [email protected] ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
Articles
Biochem Soc Trans (2011) 39 (5): 1509–1513.
Published: 21 September 2011
... organismal viability. 1 To whom correspondence should be addressed (email [email protected] ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell division cycle 48 (Cdc48) mitochondrion p97 parkin ubiquitin–proteasome system VCP (p97)/Cdc48...
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Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... the altruistic role of some yeast cells to increase the fitness of the whole cell population [ 4 , 5 ]. © The Authors Journal compilation © 2011 Biochemical Society 2011 cytochrome c mitochondrion programmed cell death (PCD) reactive oxygen species (ROS) Saccharomyces cerevisiae YCA1...
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Articles
Biochem Soc Trans (2011) 39 (1): 1–13.
Published: 19 January 2011
... sclerosis complex 2) [ 65 ], and its regulator subunit raptor [regulatory associated protein of TOR] [ 66 ]. AMP-activated protein kinase (AMPK) cancer cell metabolism energy balance mitochondrion Type 2 diabetes Living cells are molecular machines that require a considerable amount...
Articles
Biochem Soc Trans (2010) 38 (6): 1523–1526.
Published: 24 November 2010
... compilation © 2010 Biochemical Society 2010 mitochondrion protein synthesis release factor stop codon translation termination Mitochondria are vital organelles that are present in all nucleated cells of higher eukaryotes. They play critical roles in many processes, including calcium...
Articles
Biochem Soc Trans (2010) 38 (5): 1322–1328.
Published: 24 September 2010
... 2010 Biochemical Society 2010 arginine half-life mathematical model mitochondrion NaH 14 CO 3 pulse–chase We are interested in mitochondrial turnover because replacing damaged mitochondria is an important potential quality control mechanism. Mitochondrial dysfunction...
Articles
Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
... Society 2010 brain cardioprotection heart mitochondrion permeability transition pore (PTP) reperfusion injury David Keilin was a pioneer in the study of mitochondrial electron transfer and bioenergetics who discovered the key role of cytochromes in substrate oxidation [ 1...
Articles
Biochem Soc Trans (2010) 38 (3): 817–822.
Published: 24 May 2010
... be addressed (email [email protected] ). 15 12 2009 Arabidopsis dynamin-related protein 5B (DRP5B) light mitochondrion peroxisomal and mitochondrial division 1 (PMD1) peroxisome division and proliferation Peroxisomes exist in almost all eukaryotic cells. These small organelles, 0.1–1...
Articles
Biochem Soc Trans (2009) 37 (6): 1389–1393.
Published: 19 November 2009
...-antibodies, have also been reported to induce excitotoxicity. 1 To whom correspondence should be addressed (email [email protected] ). 14 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 dendrite dendritic bead excitotoxicity glutamate mitochondrion...
Articles
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
... and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures. © The Authors Journal compilation © 2009 Biochemical Society 2009 ATP excitotoxicity glutamate ischaemia mitochondrion oxidative stress Parts of this work were funded...
Articles
Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
... should be addressed (email [email protected] ). 5 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis atg gene Bcl-2 Beclin 1 macroautophagy mitochondrion The term autophagy (i.e. self-eating, from the Greek words auto =self and phagein...
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Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
... production indirectly, consistent with the flavin site model described [ 26 ]. 1 To whom correspondence should be addressed (email [email protected] ). 31 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 complex I mitochondrion NADH:ubiquinone...
Articles
Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... Mitochondrion 2001 1 33 49 8 Augustin S. Nolden M. Muller S. Hardt O. Arnold I. Langer T. Characterization of peptides released from mitochondria: evidence for constant proteolysis and peptide efflux J. Biol. Chem. 2005 280 2691 2699 9 Tatsuta T. Langer...
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Biochem Soc Trans (2008) 36 (3): 517–519.
Published: 21 May 2008
... that may be involved in that process. 1 To whom correspondence should be addressed (email [email protected] ). 22 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase...
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Biochem Soc Trans (2007) 35 (6): 1643–1647.
Published: 23 November 2007
[email protected] ). 2 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Arabidopsis thaliana chloroplast mitochondrion pentatricopeptide repeat (PPR) RNA binding tetratricopeptide repeat (TPR) Transcription in plant organelles often yields multiple primary...
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Biochem Soc Trans (2007) 35 (5): 1052–1054.
Published: 25 October 2007
... 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cardioprotection ischaemia ischaemic preconditioning mitochondrion protein kinase Cϵ (PKCϵ) receptor for activated C-kinase (RACK) Myocardial ischaemia occurs when blood flow to the heart is impaired...
Articles
Biochem Soc Trans (2007) 35 (5): 1224–1227.
Published: 25 October 2007
... and the pentose phosphate pathway in neurons. This may have implications for our understanding of the mechanisms of neurodegeneration due to oxidative and nitrosative stress. © The Authors Journal compilation © 2007 Biochemical Society 2007 AMP-activated protein kinase astrocyte mitochondrion...
Articles
Biochem Soc Trans (2007) 35 (5): 1228–1231.
Published: 25 October 2007
... mitochondrion Morbus Parkinson neurodegenerative disorder This review summarizes recent functional and genetic findings reporting a mitochondrial impairment in certain neurodegenerative diseases, such as Morbus Parkinson, FRDA (Friedreich's ataxia), ALS (amyotrophic lateral sclerosis) and temporal...
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Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... metabolism diabetes gene expression glucose insulin secretion mitochondrion The endocrine islets of Langerhans contain four major cell types: insulin-secreting β-cells, glucagon-secreting α-cells, somatostatin-releasing δ-cells and pancreatic polypeptide-producing cells. Nutrients, hormones...
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Articles
Biochem Soc Trans (2007) 35 (2): 401–404.
Published: 20 March 2007
[email protected] ). 26 10 2006 © 2007 The Biochemical Society 2007 agmatine amino acid guanidine compound mitochondrion polyamine transport It would seem that the presence of both a guanidine and a carboxy group is incompatible with transport across the RLM, as demonstrated...
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Biochem Soc Trans (2007) 35 (2): 343–348.
Published: 20 March 2007
... cells. Scale bar, 1 μm. Mitochondria therefore appear to play a pivotal role in determining the differential response between sensitive and drug-resistant cells. hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell The cytotoxicity of BSAO (bovine serum...
Articles
Biochem Soc Trans (2006) 34 (5): 811–814.
Published: 25 October 2006
... metabolism in the β-cells. 1 To whom correspondence should be addressed (email [email protected] ). 6 7 2006 © 2006 The Biochemical Society 2006 Aralar1 β-cell energy metabolism malate–aspartate shuttle mitochondrion redox shuttle The significance of redox...
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Biochem Soc Trans (2006) 34 (6): 1283–1286.
Published: 25 October 2006
[email protected] ). 19 7 2006 © 2006 The Biochemical Society 2006 apoptosis cytochrome c global cerebral ischaemia mitochondrion p53 pifithrin-α Current evidence indicates that the tumour suppressor gene p53 encodes a sequence-specific transcription factor that controls...