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Manganese superoxide dismutase in carcinogenesis: friend or foe?

Anja Konzack, Thomas Kietzmann

Biochem Soc Trans (2014) 42 (4): 1012–1016.

DOI: https://doi.org/10.1042/BST20140076

Published: 11 August 2014

... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 inflammation liver failure manganese superoxide dismutase mitochondrion reactive oxygen species Apart from being a substrate in various enzyme reactions, oxygen appears to be also the universal electron...

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Articles

Mitochondria and redox homoeostasis as chemotherapeutic targets

Margaret M. Briehl, Margaret E. Tome, Sarah T. Wilkinson, Melba C. Jaramillo, Kristy Lee

Biochem Soc Trans (2014) 42 (4): 939–944.

DOI: https://doi.org/10.1042/BST20140087

Published: 11 August 2014

... lymphoma metabolism mitochondrion redox homoeostasis Cancer cells frequently function with a more oxidized redox environment [ 1 ]. An expanded set of cancer hallmarks was proposed by Luo et al. in 2009 [ 2 ] and includes oxidative stress. Indications of altered cellular redox homoeostasis...

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Articles

Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes

Paola Venco, Sabrina Dusi, Lorella Valletta, Valeria Tiranti

Biochem Soc Trans (2014) 42 (4): 1069–1074.

DOI: https://doi.org/10.1042/BST20140106

Published: 11 August 2014

.... 1 To whom correspondence should be addressed (email: tiranti@istituto-besta.it ). 22 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 brain coenzyme A (CoA) inborn error of metabolism mitochondrion neurodegeneration pantothenate kinase 2 (PANK2...

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Articles

Targeting mitochondria to restore failed adaptation to exercise in diabetes

Kate Geary, Leslie A. Knaub, Irene E. Schauer, Amy C. Keller, Peter A. Watson, Matthew W. Miller, Chrystelle V. Garat, Kristen J. Nadeau, Melanie Cree-Green, Subbiah Pugazhenthi, Judith G. Regensteiner, Dwight J. Klemm, Jane E.B. Reusch

Biochem Soc Trans (2014) 42 (2): 231–238.

DOI: https://doi.org/10.1042/BST20130283

Published: 20 March 2014

... To whom correspondence should be addressed (email jane.reusch@ucdenver.edu ). 19 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cAMP-response-element-binding protein (CREB) cardiovascular disease diabetes exercise mitochondrion nitric oxide synthase (NOS...

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Articles

cAMP signalling meets mitochondrial compartments

Konstantinos Lefkimmiatis

Biochem Soc Trans (2014) 42 (2): 265–269.

DOI: https://doi.org/10.1042/BST20130281

Published: 20 March 2014

... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling Mitochondria are marvels of compartmentalization, and this property is intimately connected with their function. Compartmentalization of these organelles is achieved thanks to two structures...

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Articles

Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease

Eve M. Simcox, Amy Reeve, Doug Turnbull

Biochem Soc Trans (2013) 41 (6): 1618–1624.

DOI: https://doi.org/10.1042/BST20130189

Published: 20 November 2013

... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...

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Articles

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

Joel E. Beevers, Tara M. Caffrey, Richard Wade-Martins

Biochem Soc Trans (2013) 41 (6): 1503–1508.

DOI: https://doi.org/10.1042/BST20130194

Published: 20 November 2013

... Biochemical Society 2013 autophagy dopaminergic neuron induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) mitochondrion Parkinson’s disease (PD) Despite decades of research, the complex multi-factorial aetiology of PD (Parkinson's disease) is still not well understood...

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Articles

Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins

Nicol Birsa, Rosalind Norkett, Nathalie Higgs, Guillermo Lopez-Domenech, Josef T. Kittler

Biochem Soc Trans (2013) 41 (6): 1525–1531.

DOI: https://doi.org/10.1042/BST20130234

Published: 20 November 2013

... mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking The brain is only 2% of the body's weight, but it uses 20% of the body's resting energy production. This high level of energy consumption is mainly used to reverse the ion fluxes that underlie action potential signalling...

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Articles

Role of cryo-ET in membrane bioenergetics research

Karen M. Davies, Bertram Daum

Biochem Soc Trans (2013) 41 (5): 1227–1234.

DOI: https://doi.org/10.1042/BST20130029

Published: 23 September 2013

... research. 1 To whom correspondence should be addressed (email karen.davies@biophys.mpg.de ). 13 3 2013 © 2013 The Authors 2013 chloroplast cryo-electron tomography membrane bioenergetics membrane protein organization mitochondrion Membrane bioenergetics is the study...

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Articles

Accessory subunits of mitochondrial complex I

Katarzyna Kmita, Volker Zickermann

Biochem Soc Trans (2013) 41 (5): 1272–1279.

DOI: https://doi.org/10.1042/BST20130091

Published: 23 September 2013

... 2013 © 2013 The Authors 2013 accessory subunit assembly mitochondrion NADH:ubiquinone oxidoreductase respiratory complex I Proton-translocating NADH:ubiquinone oxidoreductase (respiratory complex I) is a very large and complex membrane protein [ 1 ]. Fourteen central subunits...

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The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins

Heike Angerer

Biochem Soc Trans (2013) 41 (5): 1335–1341.

DOI: https://doi.org/10.1042/BST20130116

Published: 23 September 2013

... protein) mitochondrion oxidative phosphorylation complex (OXPHOS complex) Mitochondria harbour fundamental functions of cell metabolism. The mitochondrial OXPHOS (oxidative phosphorylation) complexes are central for the efficient production of ATP. In addition to supplying energy, mitochondria...

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Articles

Tight knots in proteins: can they block the mitochondrial pores?

Piotr Szymczak

Biochem Soc Trans (2013) 41 (2): 620–624.

DOI: https://doi.org/10.1042/BST20120261

Published: 21 March 2013

... of knotted protein translocation, which show how the knot can indeed block the pore. 1 email piotr.szymczak@fuw.edu.pl 1 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 conformational change knot mitochondrion molecular dynamics protein...

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Articles

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

Fei Yin, Tianyi Jiang, Enrique Cadenas

Biochem Soc Trans (2013) 41 (1): 101–105.

DOI: https://doi.org/10.1042/BST20120260

Published: 29 January 2013

... kinase) pathway is induced by increased oxidative stress and JNK translocation to the mitochondrion results in impairment of energy metabolism. Moreover, IIS and JNK signalling interact with and antagonize each other. This review focuses on functional outcomes of a metabolic triad that entails the co...

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Articles

Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria

Ruben Quintana-Cabrera, Juan P. Bolaños

Biochem Soc Trans (2013) 41 (1): 106–110.

DOI: https://doi.org/10.1042/BST20120252

Published: 29 January 2013

... be addressed (email jbolanos@usal.es ). 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 γ-glutamylcysteine glutathione mitochondrion reactive oxygen species One of the most efficient forms for energy production in aerobic organisms is carried out...

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Articles

The ATP synthase: the understood, the uncertain and the unknown

John E. Walker

Biochem Soc Trans (2013) 41 (1): 1–16.

DOI: https://doi.org/10.1042/BST20110773

Published: 29 January 2013

... synthase bacterium chloroplast energy cost mitochondrion protonmotive force rotor stator “From the earliest times breathing and the warmth of the body were recognized as the chief manifestations of life”. So wrote David Keilin at the beginning of the first chapter of his book The History...

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Articles

Beyond retrograde and anterograde signalling: mitochondrial–nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility

Scott W. Ballinger

Biochem Soc Trans (2013) 41 (1): 111–117.

DOI: https://doi.org/10.1042/BST20120227

Published: 29 January 2013

... for survival and reproductive success during evolution. 1 email sballing@uab.edu 18 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 bioenergetics disease susceptibility mitochondrion oxidant The genetic basis for common diseases associated...

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Articles

Role of p90 RSK in regulating the Crabtree effect: implications for cancer

Emily K. Redman, Paul S. Brookes, Marcin K. Karcz

Biochem Soc Trans (2013) 41 (1): 124–126.

DOI: https://doi.org/10.1042/BST20120277

Published: 29 January 2013

...), in the Crabtree effect. 1 To whom correspondence should be addressed (email paul_brookes@urmc.rochester.edu ). 24 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer Crabtree effect extracellular-signal-regulated kinase 5 (ERK5) mitochondrion p90...

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Articles

Rab proteins of the endoplasmic reticulum: functions and interactors

Carolina Ortiz Sandoval, Thomas Simmen

Biochem Soc Trans (2012) 40 (6): 1426–1432.

DOI: https://doi.org/10.1042/BST20120158

Published: 21 November 2012

... of autophagosomes. 1 To whom correspondence should be addressed (email Thomas.Simmen@ualberta.ca ). 27 6 2012 © 2012 The Authors Journal 2012 endoplasmic reticulum (ER) Golgi complex GTPase mitochondria-associated membrane (MAM) mitochondrion Rab The organelles of eukaryotic...

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Articles

The mystery of mitochondrial RNases

Francesco Bruni, Pasqua Gramegna, Robert N. Lightowlers, Zofia M.A. Chrzanowska-Lightowlers

Biochem Soc Trans (2012) 40 (4): 865–869.

DOI: https://doi.org/10.1042/BST20120022

Published: 20 July 2012

... of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion. 1 To whom correspondence should be addressed (email zofia.chrzanowska-lightowlers@ncl.ac.uk ). 26...

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Articles

The ERMES complex and ER–mitochondria connections

Agnès H. Michel, Benoît Kornmann

Biochem Soc Trans (2012) 40 (2): 445–450.

DOI: https://doi.org/10.1042/BST20110758

Published: 21 March 2012

... ). 1 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cardiolipin cytosol endoplasmic reticulum (ER) endoplasmic reticulum–mitochondria encounter structure (ERMES) lipid binding mitochondrion The eukaryotic cell is a highly complex entity that carries...

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Articles

Mitochondrial organization and Ca 2+ uptake

Marnie L. Olson, Susan Chalmers, John G. McCarron

Biochem Soc Trans (2012) 40 (1): 158–167.

DOI: https://doi.org/10.1042/BST20110705

Published: 19 January 2012

... calcium uptake local calcium signalling mitochondrion store organization tether Mitochondria provide energy, in the form of ATP, for many cellular processes via oxidative phosphorylation through the electron-transport chain and, in addition to energy production, mitochondria accumulate...

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Articles

Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis

Emma L. Bastow, Campbell W. Gourlay, Mick F. Tuite

Biochem Soc Trans (2011) 39 (5): 1482–1487.

DOI: https://doi.org/10.1042/BST0391482

Published: 21 September 2011

... to either of these authors (email M.F.Tuite@kent.ac.uk and C.W.Gourlay@kent.ac.uk ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...

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Articles

Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina

Heinz D. Osiewacz

Biochem Soc Trans (2011) 39 (5): 1488–1492.

DOI: https://doi.org/10.1042/BST0391488

Published: 21 September 2011

... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...

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Articles

Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species

Balaraman Kalyanaraman

Biochem Soc Trans (2011) 39 (5): 1221–1225.

DOI: https://doi.org/10.1042/BST0391221

Published: 21 September 2011

... dichlorodihydrofluorescein or dihydrorhodamine. 1 email balarama@mcw.edu . 15 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide...

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Articles

Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

Irina G. Shabalina, Jan Nedergaard

Biochem Soc Trans (2011) 39 (5): 1305–1309.

DOI: https://doi.org/10.1042/BST0391305

Published: 21 September 2011

... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...

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Articles

Mitochondrial quality control by the ubiquitin–proteasome system

Eric B. Taylor, Jared Rutter

Biochem Soc Trans (2011) 39 (5): 1509–1513.

DOI: https://doi.org/10.1042/BST0391509

Published: 21 September 2011

... organismal viability. 1 To whom correspondence should be addressed (email rutter@biochem.utah.edu ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell division cycle 48 (Cdc48) mitochondrion p97 parkin ubiquitin–proteasome system VCP (p97)/Cdc48...

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Articles

Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Maria João Sousa, Flávìa Azevedo, Ana Pedras, Carolina Marques, Olga P. Coutinho, Ana Preto, Hernâni Gerós, Susana R. Chaves, Manuela Côrte-Real

Biochem Soc Trans (2011) 39 (5): 1533–1537.

DOI: https://doi.org/10.1042/BST0391533

Published: 21 September 2011

.... 1 To whom correspondence should be addressed (email mcortereal@bio.uminho.pt ). 31 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis cathepsin D lysosome mitochondrion Pep4p vacuole In the last decade, it has been demonstrated...

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Articles

Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Nicoletta Guaragnella, Lucia Antonacci, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio

Biochem Soc Trans (2011) 39 (5): 1538–1543.

DOI: https://doi.org/10.1042/BST0391538

Published: 21 September 2011

... Society 2011 cytochrome c mitochondrion programmed cell death (PCD) reactive oxygen species (ROS) Saccharomyces cerevisiae YCA1 The term PCD (programmed cell death) describes a highly heterogeneous process regulated by distinct but sometimes overlapping pathways including apoptosis...

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Articles

The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease

Hannah R. Bridges, James A. Birrell, Judy Hirst

Biochem Soc Trans (2011) 39 (3): 799–806.

DOI: https://doi.org/10.1042/BST0390799

Published: 20 May 2011

... mitochondrial DNA mutation (mtDNA mutation) mitochondrion NADH:ubiquinone oxidoreductase (complex I) ND subunit Complex I (NADH:ubiquinone oxidoreductase) is a complicated multisubunit enzyme found in the mitochondrial inner membrane of many eukaryotes and in the cytoplasmic membrane of many aerobic...

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Articles

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

D. Grahame Hardie

Biochem Soc Trans (2011) 39 (1): 1–13.

DOI: https://doi.org/10.1042/BST0390001

Published: 19 January 2011

... it. 1 email d.g.hardie@dundee.ac.uk 11 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) cancer cell metabolism energy balance mitochondrion Type 2 diabetes Living cells are molecular machines that require...

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Articles

Translation termination in human mitochondrial ribosomes

Ricarda Richter, Aleksandra Pajak, Sven Dennerlein, Agata Rozanska, Robert N. Lightowlers, Zofia M.A. Chrzanowska-Lightowlers

Biochem Soc Trans (2010) 38 (6): 1523–1526.

DOI: https://doi.org/10.1042/BST0381523

Published: 24 November 2010

... compilation © 2010 Biochemical Society 2010 mitochondrion protein synthesis release factor stop codon translation termination Mitochondria are vital organelles that are present in all nucleated cells of higher eukaryotes. They play critical roles in many processes, including calcium...

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Articles

Correction of radiolabel pulse–chase data by a mathematical model: application to mitochondrial turnover studies

Satomi Miwa, Conor Lawless, Thomas von Zglinicki

Biochem Soc Trans (2010) 38 (5): 1322–1328.

DOI: https://doi.org/10.1042/BST0381322

Published: 24 September 2010

... 2010 Biochemical Society 2010 arginine half-life mathematical model mitochondrion NaH 14 CO 3 pulse–chase We are interested in mitochondrial turnover because replacing damaged mitochondria is an important potential quality control mechanism. Mitochondrial dysfunction...

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Articles

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

Andrew P. Halestrap

Biochem Soc Trans (2010) 38 (4): 841–860.

DOI: https://doi.org/10.1042/BST0380841

Published: 26 July 2010

... Society 2010 brain cardioprotection heart mitochondrion permeability transition pore (PTP) reperfusion injury David Keilin was a pioneer in the study of mitochondrial electron transfer and bioenergetics who discovered the key role of cytochromes in substrate oxidation [ 1...

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Articles

Peroxisome division and proliferation in plants

Kyaw Aung, Xinchun Zhang, Jianping Hu

Biochem Soc Trans (2010) 38 (3): 817–822.

DOI: https://doi.org/10.1042/BST0380817

Published: 24 May 2010

... in the division of these metabolically associated plant organelles. 1 To whom correspondence should be addressed (email huji@msu.edu ). 15 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 Arabidopsis dynamin-related protein 5B (DRP5B) light mitochondrion...

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Articles

Rapid dendritic and axonal responses to neuronal insults

Sarah M. Mizielinska, Sam M. Greenwood, Hemanth Tummala, Christopher N. Connolly

Biochem Soc Trans (2009) 37 (6): 1389–1393.

DOI: https://doi.org/10.1042/BST0371389

Published: 19 November 2009

... mitochondrion spine Immediate neuronal responses to insult include the rapid formation of neuritic swellings (termed varicosities or beads), mitochondrial dysfunction, decreased ATP concentration, microtubule collapse and neuronal inactivation. In the present review, we summarize current knowledge...

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Articles

Spare respiratory capacity, oxidative stress and excitotoxicity

David G. Nicholls

Biochem Soc Trans (2009) 37 (6): 1385–1388.

DOI: https://doi.org/10.1042/BST0371385

Published: 19 November 2009

... and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures. 1 email dnicholls@buckinstitute.org 4 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 ATP excitotoxicity glutamate ischaemia mitochondrion...

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Life, death and burial: multifaceted impact of autophagy

Lorenzo Galluzzi, Eugenia Morselli, José Miguel Vicencio, Oliver Kepp, Nicholas Joza, Nicolas Tajeddine, Guido Kroemer

Biochem Soc Trans (2008) 36 (5): 786–790.

DOI: https://doi.org/10.1042/BST0360786

Published: 19 September 2008

... compilation © 2008 Biochemical Society 2008 apoptosis atg gene Bcl-2 Beclin 1 macroautophagy mitochondrion The term autophagy (i.e. self-eating, from the Greek words auto =self and phagein =to eat) comprises a number of multiple intracellular processes, including CMA (chaperone-mediated...

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Articles

The production of reactive oxygen species by complex I

Judy Hirst, Martin S. King, Kenneth R. Pryde

Biochem Soc Trans (2008) 36 (5): 976–980.

DOI: https://doi.org/10.1042/BST0360976

Published: 19 September 2008

... mitochondrion NADH:ubiquinone oxidoreductase oxidative stress reactive oxygen species (ROS) reverse electron transport The electron transport chain in mitochondria is a significant source of cellular ROS. Historically, respiratory complexes I and III have been considered two major sources...

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Articles

Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

Naila Rabbani, Paul J. Thornalley

Biochem Soc Trans (2008) 36 (5): 1045–1050.

DOI: https://doi.org/10.1042/BST0361045

Published: 19 September 2008

... that are the targets for dicarbonyl glycation. 1 To whom correspondence should be addressed (email P.J.Thornalley@warwick.ac.uk ). 1 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 advanced glycation end-product (AGE) dicarbonyl glycation mitochondrion oxidative...

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Articles

Polyadenylation and degradation of mRNA in mammalian mitochondria: a missing link?

Agnieszka J. Bobrowicz, Robert N. Lightowlers, Zofia Chrzanowska-Lightowlers

Biochem Soc Trans (2008) 36 (3): 517–519.

DOI: https://doi.org/10.1042/BST0360517

Published: 21 May 2008

... that may be involved in that process. 1 To whom correspondence should be addressed (email agnieszka.bobrowicz@ncl.ac.uk ). 22 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase...

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Articles

Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles

E. Delannoy, W.A. Stanley, C.S. Bond, I.D. Small

Biochem Soc Trans (2007) 35 (6): 1643–1647.

DOI: https://doi.org/10.1042/BST0351643

Published: 23 November 2007

...@cyllene.uwa.edu.au ). 2 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Arabidopsis thaliana chloroplast mitochondrion pentatricopeptide repeat (PPR) RNA binding tetratricopeptide repeat (TPR) Transcription in plant organelles often yields multiple primary...

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Articles

Mitochondrial dysfunction in neurodegenerative disorders

M. Baron, A.P. Kudin, W.S. Kunz

Biochem Soc Trans (2007) 35 (5): 1228–1231.

DOI: https://doi.org/10.1042/BST0351228

Published: 25 October 2007

... compilation © 2007 Biochemical Society 2007 amyotrophic lateral sclerosis (ALS) Friedreich's ataxia mitochondrion Morbus Parkinson neurodegenerative disorder This review summarizes recent functional and genetic findings reporting a mitochondrial impairment in certain neurodegenerative...

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Articles

Amino acid metabolism, insulin secretion and diabetes

P. Newsholme, K. Bender, A. Kiely, L. Brennan

Biochem Soc Trans (2007) 35 (5): 1180–1186.

DOI: https://doi.org/10.1042/BST0351180

Published: 25 October 2007

... To whom correspondence should be addressed (email philip.newsholme@ucd.ie ). 25 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 amino acid metabolism diabetes gene expression glucose insulin secretion mitochondrion The endocrine islets...

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Articles

Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide

J.P. Bolaños, A. Herrero-Mendez, S. Fernandez-Fernandez, A. Almeida

Biochem Soc Trans (2007) 35 (5): 1224–1227.

DOI: https://doi.org/10.1042/BST0351224

Published: 25 October 2007

... 2007 Biochemical Society 2007 AMP-activated protein kinase astrocyte mitochondrion neurodegeneration pentose phosphate pathway (PPP) 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase NO is formed by NOS (NO synthase) from L -arginine [ 1 ] in all brain cells [ 2 ]. In neurons...

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Articles

Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

G.R. Budas, D. Mochly-Rosen

Biochem Soc Trans (2007) 35 (5): 1052–1054.

DOI: https://doi.org/10.1042/BST0351052

Published: 25 October 2007

... mitochondrion protein kinase Cϵ (PKCϵ) receptor for activated C-kinase (RACK) Myocardial ischaemia occurs when blood flow to the heart is impaired, such as during AMI (acute myocardial infarction) or coronary bypass surgery. Restoration of coronary blood flow (reperfusion) is a prerequisite...

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Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism

T.M. Weiger, S. Colombatto, V. Kainz, W. Heidegger, M.A. Grillo, A. Hermann

Biochem Soc Trans (2007) 35 (2): 391–395.

DOI: https://doi.org/10.1042/BST0350391

Published: 20 March 2007

... ). 2 These authors contributed equally to this work. 2 10 2006 © 2007 The Biochemical Society 2007 cell cycle cell proliferation mitochondrion ornithine decarboxylase (ODC) potassium channel quinidine Potassium channels are found ubiquitously in animal and plant...

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Inhibition of agmatine transport in liver mitochondria by new charge-deficient agmatine analogues

M.A. Grillo, V. Battaglia, S. Colombatto, C.A. Rossi, A.R. Simonian, M. Salvi, A.R. Khomutov, A. Toninello

Biochem Soc Trans (2007) 35 (2): 401–404.

DOI: https://doi.org/10.1042/BST0350401

Published: 20 March 2007

... is a single-binding, centre-gated pore rather than a channel. 1 To whom correspondence should be addressed (email antonio.toninello@unipd.it ). 26 10 2006 © 2007 The Biochemical Society 2007 agmatine amino acid guanidine compound mitochondrion polyamine transport...

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MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells

E. Agostinelli, G. Tempera, L. Dalla Vedova, M. Condello, G. Arancia

Biochem Soc Trans (2007) 35 (2): 343–348.

DOI: https://doi.org/10.1042/BST0350343

Published: 20 March 2007

... were observed. 1 To whom correspondence should be addressed (email enzo.agostinelli@uniroma1.it ). 25 10 2006 © 2007 The Biochemical Society 2007 hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell The cytotoxicity of BSAO (bovine serum...

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The importance of redox shuttles to pancreatic β-cell energy metabolism and function

K. Bender, P. Newsholme, L. Brennan, P. Maechler

Biochem Soc Trans (2006) 34 (5): 811–814.

DOI: https://doi.org/10.1042/BST0340811

Published: 25 October 2006

... metabolism in the β-cells. 1 To whom correspondence should be addressed (email philip.newsholme@ucd.ie ). 6 7 2006 © 2006 The Biochemical Society 2006 Aralar1 β-cell energy metabolism malate–aspartate shuttle mitochondrion redox shuttle The significance of redox...

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Mitochondrial diabetes and its lessons for common Type 2 diabetes

J.A. Maassen, L.M. 't Hart, G.M.C. Janssen, E. Reiling, J.A. Romijn, H.H. Lemkes

Biochem Soc Trans (2006) 34 (5): 819–823.

DOI: https://doi.org/10.1042/BST0340819

Published: 25 October 2006

... with a particular diabetic subtype, designated MIDD (maternally inherited diabetes and deafness). This mutation causes an imbalance in the mitochondrion between proteins encoded by the nuclear and mitochondrial genomes, resulting in a gradual deterioration of glucose homoeostasis during life. Remarkably, carriers...

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