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Keyword: mitophagy
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Biochem Soc Trans (2018) 46 (4): 829-842.
Published: 09 July 2018
... present an opportunity for a new class of proteins to target therapeutically with the aim of promoting mitophagy and the ubiquitin–proteasome system. The brain is enormously metabolically active, placing a large emphasis on maintaining ATP supply. Therefore, identifying mechanisms to sustain mitochondrial...
Biochem Soc Trans (2017) 45 (6): 1213-1223.
Published: 20 October 2017
... and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes...
Biochem Soc Trans (2016) 44 (4): 1091-1100.
Published: 15 August 2016
... that are transgenic for fluorescent LC3 (the hallmark of autophagy) we quantified autophagosomes in cleavage stage embryos. We confirmed that the autophagosome count peaks in four-cell embryos and this correlates with a drop in the mtDNA content of the whole embryo. This suggests removal by mitophagy...
Biochem Soc Trans (2015) 43 (2): 297-301.
Published: 07 April 2015
... Journal compilation © 2015 Biochemical Society 2015 apoptosis endoplasmic reticulum (ER)-mitochondria contacts mitophagy mitochondrial dynamics phosphatase and tensin homologue-induced putative kinase 1 (PINK1) Parkin Parkinson's disease (PD), the most common movement disorder, is...
Biochem Soc Trans (2015) 43 (2): 287-291.
Published: 07 April 2015
... ). 8 1 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 mitochondria mitophagy organellar quality control phosphatase and tensin homologue-induced kinase 1 (PINK1) protein import Mitochondria have been traditionally regarded mainly as sources for energy...
Biochem Soc Trans (2015) 43 (1): 108-110.
Published: 26 January 2015
... Journal compilation © 2015 Biochemical Society 2015 Cdc48/VCP/p97 endoplasmic-reticulum–mitochondria encounter structure (ERMES) lipid metabolism mitochondria mitophagy small GTPase The communication between organelles of the secretory pathway is an essential part of the life of any...
Biochem Soc Trans (2014) 42 (5): 1302-1310.
Published: 18 September 2014
..., distribution and reproduction in any medium, provided the original work is properly cited. calcium fission fusion gliotransmission mitophagy trafficking Astrocytes are a subset of glial cells that provide trophic and structural support for neurons. Accumulating evidence over the last few...
Biochem Soc Trans (2013) 41 (6): 1525-1531.
Published: 20 November 2013
... mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking The brain is only 2% of the body's weight, but it uses 20% of the body's resting energy production. This high level of energy consumption is mainly used to reverse the ion fluxes that underlie action potential signalling...
Biochem Soc Trans (2011) 39 (5): 1514-1519.
Published: 21 September 2011
..., aggregated proteins or dysfunctional mitochondria. This is considered to counteract the development of a number of neurodegenerative disorders and aging. Here we review the role of mitophagy and mitochondrial dynamics in ensuring quality control of mitochondria. In particular, we provide possible...
Biochem Soc Trans (2010) 38 (3): 789-795.
Published: 24 May 2010
... compilation © 2010 Biochemical Society 2010 clueless cytoskeleton FRIENDLY mitochondrial dynamics mitophagy Parkin The discovery of mitochondria cannot be attributed to a single person, because many of the granular bodies observed by cytologists during the years 1850–1890, and given a...