...Natalie M. Niemi; Jonathan R. Friedman Mitochondria maintain organellar homeostasis through multiple quality control pathways, including the clearance of defective or unwanted mitochondria by selective autophagy. This removal of mitochondria, mitophagy, is controlled in large part by the outer...

...Vijigisha Srivastava; Einav Gross The removal of damaged mitochondrial components through a process called mitochondrial autophagy (mitophagy) is essential for the proper function of the mitochondrial network. Hence, mitophagy is vital for the health of all aerobic animals, including humans...

... in mitophagy, the process of selective autophagic elimination of damaged mitochondria. Impaired mitophagy has been associated with sporadic Parkinson's and agents that damage mitochondria are known to induce Parkinson's-like motor symptoms in humans and animal models. Thus, modulating mitophagy pathways may...

... in this disease. In recent years, defective mitochondrial elimination through autophagy, termed mitophagy, has emerged as a potential contributing factor to disease pathology. PINK1 and Parkin, two proteins mutated in familial PD, were found to eliminate mitochondria under distinct mitochondrial depolarisation...

... and present an opportunity for a new class of proteins to target therapeutically with the aim of promoting mitophagy and the ubiquitin–proteasome system. The brain is enormously metabolically active, placing a large emphasis on maintaining ATP supply. Therefore, identifying mechanisms to sustain mitochondrial...

... and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes mellitus, sepsis...

... that are transgenic for fluorescent LC3 (the hallmark of autophagy) we quantified autophagosomes in cleavage stage embryos. We confirmed that the autophagosome count peaks in four-cell embryos and this correlates with a drop in the mtDNA content of the whole embryo. This suggests removal by mitophagy (mitochondria...

... 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 mitochondria mitophagy organellar quality control phosphatase and tensin homologue-induced kinase 1 (PINK1) protein import Mitochondria have been traditionally regarded mainly as sources for energy...

...)-mitochondria contacts mitophagy mitochondrial dynamics phosphatase and tensin homologue-induced putative kinase 1 (PINK1) Parkin 1 To whom correspondence should be addressed (email [email protected] ). 12 1 2015 Parkinson's disease (PD), the most common movement disorder...

... complex J. Biol. Chem. 2007 282 29678 29690 10.1074/jbc.M704339200 17684017 5 Böckler S. Westermann B. Mitochondrial ER contacts are crucial for mitophagy in yeast Dev. Cell 2014 28 450 458 10.1016/j.devcel.2014.01.012 24530295 6 Klecker T. Böckler S...

... mitophagy trafficking Astrocytes are a subset of glial cells that provide trophic and structural support for neurons. Accumulating evidence over the last few years has revealed that astrocytes are active regulators of information processing in the central nervous system (CNS) [ 1 – 5...

... mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking The brain is only 2% of the body's weight, but it uses 20% of the body's resting energy production. This high level of energy consumption is mainly used to reverse the ion fluxes that underlie action potential signalling...

..., aggregated proteins or dysfunctional mitochondria. This is considered to counteract the development of a number of neurodegenerative disorders and aging. Here we review the role of mitophagy and mitochondrial dynamics in ensuring quality control of mitochondria. In particular, we provide possible...

... compilation © 2010 Biochemical Society 2010 clueless cytoskeleton FRIENDLY mitochondrial dynamics mitophagy Parkin The discovery of mitochondria cannot be attributed to a single person, because many of the granular bodies observed by cytologists during the years 1850–1890, and given...