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Keyword: mitosis
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Articles
Biochem Soc Trans (2017) 45 (2): 313-322.
Published: 13 April 2017
...Ee Phie Tan; Francesca E. Duncan; Chad Slawson Cell division (mitosis) and gamete production (meiosis) are fundamental requirements for normal organismal development. The mammalian cell cycle is tightly regulated by different checkpoints ensuring complete and precise chromosomal segregation and...
Articles
Biochem Soc Trans (2016) 44 (2): 510-516.
Published: 11 April 2016
...Gil Kanfer; Benoît Kornmann During mitosis, cells undergo massive deformation and reorganization, impacting on all cellular structures. Mitochondria, in particular, are highly dynamic organelles, which constantly undergo events of fission, fusion and cytoskeleton-based transport. This plasticity...
Articles
Biochem Soc Trans (2015) 43 (3): 323-327.
Published: 01 June 2015
... shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can...
Articles
Biochem Soc Trans (2015) 43 (1): 13-18.
Published: 26 January 2015
... © The Authors Journal compilation © 2015 Biochemical Society 2015 centriole centrosome detachment chromosome mitosis In cycling cells, centrioles are contained within centrosomes, small cytoplasmic organelles, which act as major microtubule-organizing centres (MTOCs) [ 1 ]. By contrast...
Articles
Biochem Soc Trans (2015) 43 (1): 19-22.
Published: 26 January 2015
...John C. Meadows; Jonathan B.A. Millar The segregation of sister chromatids during mitosis is one of the most easily visualized, yet most remarkable, events during the life cycle of a cell. The accuracy of this process is essential to maintain ploidy during cell duplication. Over the past 20 years...
Articles
Biochem Soc Trans (2014) 42 (6): 1534-1537.
Published: 17 November 2014
... © 2014 Biochemical Society 2014 actin cell cycle mitosis protein kinase Cε (PKCε) Cytokinesis is the final stage in cell division resulting in physical separation of two daughter cells (carefully reviewed [ 1 ]). During mitosis, the replicated chromosomes are segregated to opposite poles...
Articles
Biochem Soc Trans (2014) 42 (1): 76-81.
Published: 23 January 2014
...@ncl.ac.uk ). 17 7 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer cell cycle cyclin D1 mitosis nuclear factor κB (NF-κB) p53 NF-κB (nuclear factor κB) consists of the homo- and hetero-dimers formed from a family of five transcription factors...
Articles
Biochem Soc Trans (2013) 41 (6): 1755-1760.
Published: 20 November 2013
... summarize advances made in the last few years, and then focus on unexplored corners of this signalling pathway. 1 email silke.hauf@tuebingen.mpg.de 8 10 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 anaphase-promoting complex (APC) mitosis mitotic...
Articles
Biochem Soc Trans (2013) 41 (6): 1761-1765.
Published: 20 November 2013
..., which is bound to the inner centromere during early mitosis, plays a central role in both chromosome bi-orientation and the spindle checkpoint. The application of tension across centromeres establishes a spatial gradient of high phosphorylation activity at the inner centromere and low phosphorylation...
Articles
Biochem Soc Trans (2013) 41 (6): 1766-1771.
Published: 20 November 2013
...Iain M. Hagan; Agnes Grallert The activation of the Cdk1 (cyclin-dependent kinase 1)–cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit. Cdk1 phosphorylation by Wee1 kinases blocks activation until Cdc25 (cell division cycle...
Articles
Biochem Soc Trans (2011) 39 (6): 1786-1789.
Published: 21 November 2011
... centrosome and the microtubule cytoskeleton. The position of the centrosome relative to the NE is of vital importance for many cell functions, such as cell migration and division, and centrosomal dislocation is a frequent phenotype in laminopathic disorders. Also in mitosis, a small group of transmembrane NE...
Articles
Biochem Soc Trans (2011) 39 (5): 1154-1160.
Published: 21 September 2011
... cells and is therefore a novel chromokinesin. Hklp2 also associates with the microtubules specifically during mitosis, in a TPX2 (targeting protein for Xklp2)-dependent manner. We have shown that Hklp2 participates in spindle pole separation and in the maintenance of spindle bipolarity in metaphase. To...
Articles
Biochem Soc Trans (2010) 38 (6): 1709-1714.
Published: 24 November 2010
... times of the cell cycle. Specificity and fine-tuning emerge most clearly during mitosis. In the present article, we focus on the distinction between global mitotic control by the chromosomal Ran gradient and specific spatial and temporal control operated by localized Ran network members at sites of the...
Articles
Biochem Soc Trans (2010) 38 (6): 1667-1675.
Published: 24 November 2010
... segregation machinery. 1 To whom correspondence should be addressed (email cesunkel@ibmc.up.pt ). 28 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 centromere chromosome segregation kinetochore mitosis sister chromatid spindle assembly checkpoint...
Articles
Biochem Soc Trans (2010) 38 (6): 1704-1708.
Published: 24 November 2010
... suggest novel roles for Chk2 and Brca1 in mitosis that might contribute to their tumour-suppressor functions. 1 To whom correspondence should be addressed at the present address: Department of Molecular Oncology, University Medical Center Göttingen, Grisebachstrasse 8, D-37077 Göttingen...
Articles
Biochem Soc Trans (2010) 38 (1): 72-77.
Published: 19 January 2010
...Wouter van Zon; Rob M.F. Wolthuis Active cyclin B1–Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the chromosomes and for incorrect chromosome-spindle attachments to be repaired. Meanwhile, securin, an inhibitor of separase, secures...
Articles
Biochem Soc Trans (2010) 38 (1): 301-306.
Published: 19 January 2010
... progression and differentiation. During mitosis, lamins are dynamically reorganized and play active roles in spindle matrix formation and in post-mitotic nuclear reassembly. Several of the cell-cycle-regulating functions of lamins may be impaired in the diseases linked to mutations in lamins and lamin...
Articles
Biochem Soc Trans (2009) 37 (5): 976-980.
Published: 21 September 2009
...Dan Liu; Michael A. Lampson Accurate segregation of chromosomes in mitosis requires that spindle microtubules attach sister kinetochores to opposite poles of the mitotic spindle (biorientation). To achieve biorientation of all chromosomes, incorrect attachments are selectively destabilized...
Articles
Biochem Soc Trans (2008) 36 (3): 367-370.
Published: 21 May 2008
...Mar Carmena The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I...
Articles
Biochem Soc Trans (2008) 36 (1): 126-130.
Published: 22 January 2008
... ubiquitinated substrate proteins from cellular structures or segregate them from binding partners, and then hand them over for degradation or recycling. Several studies in different organisms show that Cdc48/p97 also has critical roles in mitosis. However, many important aspects of these functions and the...
Articles
Biochem Soc Trans (2006) 34 (5): 716-721.
Published: 25 October 2006
... © 2006 The Biochemical Society 2006 Aurora A importin microtubule mitosis Ran spindle Mitotic spindle assembly involves many factors that model the microtubule cytoskeleton into a bipolar structure consisting of three main types of microtubules. The astral microtubules emanate from two...
Articles
Biochem Soc Trans (2006) 34 (5): 711-715.
Published: 25 October 2006
... Biochemical Society 2006 checkpoint kinetochore mitosis nuclear pore Ran GTPase spindle The Ran GTPase is required for many cellular functions, including nucleo-cytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle control [ 1 ]. The exchange factor for Ran, RCC1...
Articles
Biochem Soc Trans (2006) 34 (3): 385-388.
Published: 22 May 2006
... calcium store is the ER (endoplasmic reticulum): the spatial organization of the ER during mitosis is important in defining a microdomain around the nucleus and mitotic spindle in early Drosophila embryos [Parry, McDougall and Whitaker (2005) J. Cell Biol. 171 , 47–59]. Nuclear divisions in syncytial...
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Articles
Biochem Soc Trans (2003) 31 (1): 263-265.
Published: 01 February 2003
...C. Morrison; P. Vagnarelli; E. Sonoda; S. Takeda; W.C. Earnshaw For successful eukaryotic mitosis, sister chromatid pairs remain linked after replication until their kinetochores have been attached to opposite spindle poles by microtubules. This linkage is broken at the metaphase–anaphase...