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Keywords: mitosis
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Biochem Soc Trans (2024) 52 (1): 455–464.
Published: 19 February 2024
...-heterochromatin, delimits RNA Pol II activity as well as the encounter with other factors acting on chromatin such as the DNA replication or DNA repair machineries. The stage of the cell cycle highly influences RNA Pol II activity with mitosis representing the major challenge. In fact, there is a massive...
Articles
Biochem Soc Trans (2022) 50 (4): 1105–1118.
Published: 30 August 2022
... in response to DSBs are inactivated in mitosis. Although cell cycle checkpoints prevent transmission of DNA lesions into mitosis under physiological condition, cancer cells frequently display mitotic DNA lesions. In this review, we aim to provide an overview of how mitotic cells process lesions that escape...
Articles
Biochem Soc Trans (2021) 49 (6): 2767–2776.
Published: 16 November 2021
... recently important discoveries have shed some light on its function and shown that Ki-67 has a major role in the formation of mitotic chromosome periphery compartment, it is associated with protein phosphatase one (PP1) and regulates chromatin function in interphase and mitosis. In this review, we discuss...
Articles
Biochem Soc Trans (2021) 49 (4): 1515–1527.
Published: 10 August 2021
... localisation and activity of the central effectors, the transcriptional co-regulators YAP and TAZ. Pathological YAP and TAZ hyperactivity consequently cause cancer, fibrosis and developmental defects. The Hippo pathway controls an array of fundamental cellular processes, including adhesion, migration, mitosis...
Articles
Biochem Soc Trans (2020) 48 (1): 245–256.
Published: 03 February 2020
..., whose maintenance requires several core and accessory proteins. Despite this complex structural organization, the Golgi apparatus is highly dynamic, and this property becomes particularly evident during mitosis, when the ribbon undergoes a multistep disassembly process that allows its correct...
Articles
Biochem Soc Trans (2017) 45 (2): 313–322.
Published: 13 April 2017
...Ee Phie Tan; Francesca E. Duncan; Chad Slawson Cell division (mitosis) and gamete production (meiosis) are fundamental requirements for normal organismal development. The mammalian cell cycle is tightly regulated by different checkpoints ensuring complete and precise chromosomal segregation...
Articles
Biochem Soc Trans (2016) 44 (2): 510–516.
Published: 11 April 2016
...Gil Kanfer; Benoît Kornmann During mitosis, cells undergo massive deformation and reorganization, impacting on all cellular structures. Mitochondria, in particular, are highly dynamic organelles, which constantly undergo events of fission, fusion and cytoskeleton-based transport. This plasticity...
Articles
Biochem Soc Trans (2015) 43 (3): 323–327.
Published: 01 June 2015
... shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can...
Articles
Biochem Soc Trans (2015) 43 (1): 13–18.
Published: 26 January 2015
... © The Authors Journal compilation © 2015 Biochemical Society 2015 centriole centrosome detachment chromosome mitosis Although not essential for mitosis, centrosomes provide an advantage to organisms, especially when mitosis must be completed in a limited time-frame...
Articles
Biochem Soc Trans (2015) 43 (1): 19–22.
Published: 26 January 2015
...John C. Meadows; Jonathan B.A. Millar The segregation of sister chromatids during mitosis is one of the most easily visualized, yet most remarkable, events during the life cycle of a cell. The accuracy of this process is essential to maintain ploidy during cell duplication. Over the past 20 years...
Articles
Biochem Soc Trans (2014) 42 (6): 1534–1537.
Published: 17 November 2014
... should be addressed (email [email protected] ). 4 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 actin cell cycle mitosis protein kinase Cε (PKCε) Cytokinesis is the final stage in cell division resulting in physical separation of two...
Articles
Biochem Soc Trans (2014) 42 (1): 76–81.
Published: 23 January 2014
... knowledge about integration of NF-κB activity with cell cycle regulation, including newly characterized direct and indirect target genes in addition to the mechanisms through which NF-κB itself can be regulated by the cell cycle. cancer cell cycle cyclin D1 mitosis nuclear factor κB (NF-κB) p53...
Articles
Biochem Soc Trans (2013) 41 (6): 1755–1760.
Published: 20 November 2013
... summarize advances made in the last few years, and then focus on unexplored corners of this signalling pathway. 1 email [email protected] 8 10 2013 anaphase-promoting complex (APC) mitosis mitotic checkpoint signalling pathway spindle assembly checkpoint...
Articles
Biochem Soc Trans (2013) 41 (6): 1761–1765.
Published: 20 November 2013
..., which is bound to the inner centromere during early mitosis, plays a central role in both chromosome bi-orientation and the spindle checkpoint. The application of tension across centromeres establishes a spatial gradient of high phosphorylation activity at the inner centromere and low phosphorylation...
Articles
Biochem Soc Trans (2013) 41 (6): 1766–1771.
Published: 20 November 2013
...Iain M. Hagan; Agnes Grallert The activation of the Cdk1 (cyclin-dependent kinase 1)–cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit. Cdk1 phosphorylation by Wee1 kinases blocks activation until Cdc25 (cell division cycle...
Articles
Biochem Soc Trans (2011) 39 (6): 1786–1789.
Published: 21 November 2011
... with the centrosome and the microtubule cytoskeleton. The position of the centrosome relative to the NE is of vital importance for many cell functions, such as cell migration and division, and centrosomal dislocation is a frequent phenotype in laminopathic disorders. Also in mitosis, a small group of transmembrane NE...
Articles
Biochem Soc Trans (2011) 39 (5): 1154–1160.
Published: 21 September 2011
... cells and is therefore a novel chromokinesin. Hklp2 also associates with the microtubules specifically during mitosis, in a TPX2 (targeting protein for Xklp2)-dependent manner. We have shown that Hklp2 participates in spindle pole separation and in the maintenance of spindle bipolarity in metaphase...
Articles
Biochem Soc Trans (2010) 38 (6): 1667–1675.
Published: 24 November 2010
... segregation machinery. 1 To whom correspondence should be addressed (email [email protected] ). 28 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 centromere chromosome segregation kinetochore mitosis sister chromatid spindle assembly checkpoint...
Articles
Biochem Soc Trans (2010) 38 (6): 1704–1708.
Published: 24 November 2010
... suggest novel roles for Chk2 and Brca1 in mitosis that might contribute to their tumour-suppressor functions. 1 To whom correspondence should be addressed at the present address: Department of Molecular Oncology, University Medical Center Göttingen, Grisebachstrasse 8, D-37077 Göttingen...
Articles
Biochem Soc Trans (2010) 38 (6): 1709–1714.
Published: 24 November 2010
... times of the cell cycle. Specificity and fine-tuning emerge most clearly during mitosis. In the present article, we focus on the distinction between global mitotic control by the chromosomal Ran gradient and specific spatial and temporal control operated by localized Ran network members at sites...
Articles
Biochem Soc Trans (2010) 38 (1): 72–77.
Published: 19 January 2010
...Wouter van Zon; Rob M.F. Wolthuis Active cyclin B1–Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the chromosomes and for incorrect chromosome-spindle attachments to be repaired. Meanwhile, securin, an inhibitor of separase, secures...
Articles
Biochem Soc Trans (2010) 38 (1): 301–306.
Published: 19 January 2010
... progression and differentiation. During mitosis, lamins are dynamically reorganized and play active roles in spindle matrix formation and in post-mitotic nuclear reassembly. Several of the cell-cycle-regulating functions of lamins may be impaired in the diseases linked to mutations in lamins and lamin...
Articles
Biochem Soc Trans (2009) 37 (5): 976–980.
Published: 21 September 2009
...Dan Liu; Michael A. Lampson Accurate segregation of chromosomes in mitosis requires that spindle microtubules attach sister kinetochores to opposite poles of the mitotic spindle (biorientation). To achieve biorientation of all chromosomes, incorrect attachments are selectively destabilized...
Articles
Biochem Soc Trans (2008) 36 (3): 367–370.
Published: 21 May 2008
...Mar Carmena The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I...
Articles
Biochem Soc Trans (2008) 36 (1): 126–130.
Published: 22 January 2008
... ubiquitinated substrate proteins from cellular structures or segregate them from binding partners, and then hand them over for degradation or recycling. Several studies in different organisms show that Cdc48/p97 also has critical roles in mitosis. However, many important aspects of these functions...
Articles
Biochem Soc Trans (2006) 34 (5): 711–715.
Published: 25 October 2006
... The Biochemical Society 2006 checkpoint kinetochore mitosis nuclear pore Ran GTPase spindle The RanBP2–RanGAP1 complex is not the only component of the interphase NPC that associates with the kinetochore during mitosis: the Nup107–Nup160 complex, which includes nine nucleoporins [ 40...
Articles
Biochem Soc Trans (2006) 34 (5): 716–721.
Published: 25 October 2006
... suggested that it might have a function in mitosis [ 4 – 6 ]. To define the mitosis-specific function of Ran, it is necessary to assay the mitotic function of Ran directly without the complication of its interphase role. A number of groups used extracts made from mature Xenopus eggs arrested in the second...
Articles
Biochem Soc Trans (2006) 34 (3): 385–388.
Published: 22 May 2006
... calcium store is the ER (endoplasmic reticulum): the spatial organization of the ER during mitosis is important in defining a microdomain around the nucleus and mitotic spindle in early Drosophila embryos [Parry, McDougall and Whitaker (2005) J. Cell Biol. 171 , 47–59]. Nuclear divisions in syncytial...
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Articles
Biochem Soc Trans (2003) 31 (1): 263–265.
Published: 01 February 2003
...C. Morrison; P. Vagnarelli; E. Sonoda; S. Takeda; W.C. Earnshaw For successful eukaryotic mitosis, sister chromatid pairs remain linked after replication until their kinetochores have been attached to opposite spindle poles by microtubules. This linkage is broken at the metaphase–anaphase...