... test kits for on-site identification of viruses (Zika and Ebola), while gene circuit cascades can be tested, debugged and re-designed within rapid turnover times. Coupled with mathematical modelling, this discipline lends itself towards the precision engineering of new synthetic life. The next stages...

... transporters heterodimer heteromeric amino acid transporter (HAT) modelling structure transport mechanism Amino acid availability regulates cell physiology. The transfer of amino acids across the plasma membrane is mediated by specific transporter proteins that recognize, bind and transport...

... modelling protocol (HGMP) and the fragment molecular orbital (FMO) quantum mechanics (QM) method to explore the interactions and selectivity of the human orexin-2 receptor (OX 2 R) and its recently discovered nonpeptidic agonists. HGMP generates a 3D model of GPCR structures and its complexes with small...

... chemicals, particularly during the early research phase. Recently, the Multi-scale framework for Sustainable Industrial Chemicals (MuSIC) was introduced to address this issue by integrating modelling approaches at different scales ranging from cellular to ecological scales. This framework can be further...

... by Portland Press Limited 2015 EPR MD simulations ABCB1 MsbA DEER PELDOR modelling protein dynamics Knowledge of the molecular structure of membrane proteins is essential to understand their function. Most direct structural information is derived from X-ray crystallography as well...

... of relating observations on isolated receptors or receptors expressed in model systems to receptor function in vivo . 1 To whom correspondence should be addressed (email D.R.Poyner@aston.ac.uk ). 20 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 β...

...Igor Goryanin Modelling and optimization principles become a key concept in many biological areas, especially in biochemistry. Definitions of objective function, fitness and co-evolution, although they differ between biology and mathematics, are similar in a general sense. Although successful...

... these observations with the known actions of mizoribine I have adapted an existing model of human purine metabolism composed as an S-system familiar from Biochemical Systems Theory. Mizoribine's actions were then simulated and compared with experimental data. 1 To whom correspondence should be addressed...

... producing synthetic data sets by simulation of realistic biochemical network models with the purpose of comparing data analysis methods. Because we have full knowledge of the underlying ‘biochemistry’ of these models, we are better able to judge how well the analyses reflect true knowledge about the system...

...M.P. Williamson Systems biology describes the collection of a set of measurements on a system, integrated with a mathematical model of that system. The model and the measurements must be made together and refined iteratively, requiring close collaboration between biologists and modellers...

... in Ligand-Gated Ion Channel Function: a Biochemical Society Focused Meeting held at Merck Shape & Dohme, Harlow, 29 January 2004 25 February 2003 © 2004 Biochemical Society 2004 γ-aminobutyric acid (GABA) ligand-gated ion channel (LGIC) LGIC activation LGIC structure modelling...

... of and other relationships, which allows its users to classify a gene, protein, compound or pathway within a knowledge base. (ii) Database models, which define the way biological information is stored in a database [2]. A database model may be derived from an ontology, in which case it shares the same logical...