...A. Graham Pockley; Brian Henderson; Gabriele Multhoff Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate...

...Peter Lund It is now well understood that, although proteins fold spontaneously (in a thermodynamic sense), many nevertheless require the assistance of helpers called molecular chaperones to reach their correct and active folded state in living cells. This is because the pathways of protein folding...

... years ago, and, since then, research in this area has expanded on a global scale. In this review, the key discoveries in this field are summarized, and recent studies of bacterial twin-arginine signal-peptide-binding proteins are discussed. membrane protein membrane transport molecular chaperone...

..., Ireland. 2 To whom correspondence should be addressed (email [email protected] ). 22 3 2005 © 2005 The Biochemical Society 2005 amyotrophic lateral sclerosis apoptosis hsp molecular chaperone motoneuron therapeutic target Neurodegenerative diseases...

... have enabled us to define a chaperone-mediated ‘proofreading’ mechanism involved in co-ordinating assembly and export of twin-arginine transport-dependent enzymes. molecular chaperone [NiFe] hydrogenase protein–protein interaction Tat protein transport system N -oxide reductase twin-arginine...

... processes governing assembly and export of Tat-dependent enzymes. molecular chaperone molybdopterin cofactor protein–protein interactions Tat protein transport system trimethylamine N -oxide (TMAO) reductase twin-arginine signal peptide TMAO (trimethylamine N -oxide) is a nitrogen...

... 2004 heat-shock protein immunophilin molecular chaperone proteasome retinal degeneration tetratricopeptide repeat LCA (Leber's congenital amaurosis) is inherited in an autosomal recessive manner and is characterized by severely impaired vision or blindness at birth. Mutations in AIPL1...