... the risk of developing ASD. Reverse translational studies using rodent models based on these genetic variants provide new insight into the biological basis of ASD. Here we review recent findings from three ASD associated CNV mouse models (16p11.2, 2p16.3 and 22q11.2 deletion) that show behavioural...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . CRISPR functional genomics genetics genome editing genomics mouse models Cancer is a complex disease initiated and driven by a diverse spectrum of genetic and epigenetic alterations...

.... Correspondence: Pamela Stanley ( [email protected] ) 12 1 2022 23 2 2022 7 3 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 glycosyltransferases intestinal development mouse models Notch signalling pathway O...

... in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. BMP endothelial to haematopoietic transition haemogenic endothelium mouse models TGFβ zebrafish TGFβ is a well-known regulator of adult...

...-specific manner. In this review, we summarise the existing nesprin mouse models, compare their phenotypes and discuss the potential mechanisms underlying nesprin-associated diseases. Correspondence: Qiuping Zhang ( [email protected] ) 6 2 2018 5 4 2018 20 4 2018 © 2018...

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models therapeutics Table 1 Overview of the therapeutic strategies for primary mitochondrial diseases...

... damage DNA mismatch repair (MMR) mouse models The generation and analysis of MMR point mutant mouse lines allows an assessment of the importance of individual MMR functions for genome stability and cancer susceptibility. The studies described here demonstrate that MMR missense mutations can...