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Keyword: mucin
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Articles
Biochem Soc Trans (2018) 46 (5): 1099-1106.
Published: 28 August 2018
...-ordinated beating of motile cilia. This mechanism of lung defence is reliant upon a flowing mucus gel, and the major macromolecular components that determine the rheological properties of mucus are the polymeric mucins, MUC5AC and MUC5B. These large O-linked glycoproteins have direct roles in maintaining...
Articles
Biochem Soc Trans (2018) 46 (3): 707-719.
Published: 25 May 2018
...Breanna A. Symmes; Adrianne L. Stefanski; Chelsea M. Magin; Christopher M. Evans In humans and mice, the first line of innate defense against inhaled pathogens and particles in the respiratory tract is airway mucus. The primary solid components of the mucus layer are the mucins MUC5AC and MUC5B...
Articles
Biochem Soc Trans (2016) 44 (1): 109-115.
Published: 09 February 2016
... © 2016 Authors; published by Portland Press Limited 2016 sulfatase arylsulfatase radical SAM radical AdoMet microbiota microbiome metagenomic glycosaminoglycan mucin The human microbiota is a complex ecosystem constituted by a trillion of commensal microorganisms mostly represented...
Articles
Biochem Soc Trans (2011) 39 (1): 340-343.
Published: 19 January 2011
..., but it may be useful in monitoring treatment of pancreatic cancer (e.g. the effectiveness of chemotherapy), as a complement to other diagnostic methods. Some other carbohydrate markers of pancreatic cancer may be considered, such as CEA (carcinoembryonic antigen), CA 50 and CA 242, and the mucins MUC1...
Articles
Biochem Soc Trans (2011) 39 (1): 388-392.
Published: 19 January 2011
...@vumc.nl ). 11 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer carcinoembryonic antigen (CEA) C-type lectin dendritic cell glycosylation mucin Glycosylation of proteins and lipids in mammalian cells is mediated by a large number of enzymes...
Articles
Biochem Soc Trans (2010) 38 (5): 1368-1373.
Published: 24 September 2010
...M. Carmen Galan; Anthony P. Corfield The present article provides an overview on mucins and their role in biological processes, while aiming to familiarize readers with the current tools available for the synthesis of structurally defined mucin-type glycan probes including the advantages and...
Articles
Biochem Soc Trans (2010) 38 (2): 358-363.
Published: 22 March 2010
... intestinal metaplasia mucin stomach Metaplasia is classically defined as a reversible change in which one epithelial or mesenchymal adult cell type is replaced by another adult cell type [ 1 ]. At least two possibilities for the cellular origin of metaplasia can be envisioned: (i...
Articles
Biochem Soc Trans (2009) 37 (4): 868-872.
Published: 22 July 2009
...Ben Nicholas; Ratko Djukanović Sputum is recognized as a sampling method for the monitoring and assessment of chronic lung diseases such as asthma, COPD (chronic obstructive pulmonary disease) and cystic fibrosis. Sputum samples the central airways and its protein components (e.g. mucins and...
Articles
Biochem Soc Trans (2008) 36 (6): 1482-1486.
Published: 19 November 2008
... (mucin 1), causing clustering of MUC1 and revealing underlying adhesion molecules which promote adhesion to endothelium. This is likely to be an important mechanism in cancer metastasis and represents a valid therapeutic target. Tools are now available to allow fast and accurate elucidation of...
Articles
Biochem Soc Trans (2007) 35 (5): 1372-1374.
Published: 25 October 2007
...-glycans formed. 1 To whom correspondence should be addressed (email tony.corfield@bristol.ac.uk ). 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis benzyl- O - N -acetyl- D -galactosamine colorectal cancer O-glycosylation mucin signal...
Articles
Biochem Soc Trans (2003) 31 (5): 1036-1041.
Published: 01 October 2003
... Nottingham, 19–20 June 2003 25 June 2003 © 2003 Biochemical Society 2003 chitosan glue protein micron size complex mucin ultracentrifuge Abbreviations used: SEC-MALLs, size-exclusion chromatography coupled to multi-angle laser light scattering; M w , weight-average...
Articles
Biochem Soc Trans (2003) 31 (2): 318-325.
Published: 01 April 2003
...I. Brockhausen This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro , it is still difficult...
Articles
Biochem Soc Trans (2001) 29 (2): 153-156.
Published: 01 May 2001
...J. D. Aplin; M. Meseguer; C. Simon; M. E. Ortíz; H. Croxatto; C. J. P. Jones As it approaches the maternal surface, the attaching embryo encounters the epithelial glycocalyx, which contains the mucin, MUC1. A high density of MUC1 at the cell surface can inhibit cell adhesion. This raises the...
Articles
Biochem Soc Trans (2001) 29 (2): 162-166.
Published: 01 May 2001
...K. L. Carraway; N. Idris Sialomucin complex (SMC/rat Muc4) is a hetero-dimeric glycoprotein complex composed of an anti-adhesive mucin subunit ascites sialoglyco-protein (ASGP)-1 and a transmembrane subunit ASGP-2. SMC expression is tightly regulated in the uterus, and its expression appears to...