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Keywords: multidrug resistance
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Biochem Soc Trans (2019) 47 (1): 23–36.
Published: 09 January 2019
... antibiotics, out of the cells and provide them with multidrug resistance. Tripartite efflux pumps span both the inner and outer membrane in a similar manner as the T1SS system. They contain an outer membrane channel, a periplasmic adaptor protein and either a resistance-nodulation-cell division (RND...
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Biochem Soc Trans (2018) 46 (6): 1485–1494.
Published: 21 November 2018
... to translate some of these findings into inhibitor design and development. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ABC transport proteins electron microscopy molecular modelling multidrug resistance pharmacokinetics transmembrane proteins...
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Biochem Soc Trans (2013) 41 (1): 293–298.
Published: 29 January 2013
... of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, and anti-tumour chemotherapeutic treatments are often impaired by innate or acquired MDR (multidrug resistance). Microvesicles released upon chemotherapeutic agents prevent...
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Biochem Soc Trans (2005) 33 (5): 1008–1011.
Published: 26 October 2005
... will be discussed in the context of functional and structural similarities that can be observed between primary- and secondary-active multidrug transporters in prokaryotic and eukaryotic cells. The ever-increasing incidence of MDR (multidrug resistance) due to the overexpression of multidrug transporters...
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Biochem Soc Trans (2005) 33 (1): 241–245.
Published: 01 February 2005
... in clinical outcome; however, critical studies aimed at proving the hypothesis using Pgp inhibitors in clinical trials have to date failed. Identification of the MRP (multidrug resistance protein)/ABCC subfamily expanded the possible mechanisms of reduced drug accumulation, and the discovery of ABCG2 added...
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