1-8 of 8
Keywords: multidrug resistance
Sort by
Biochem Soc Trans (2019) 47 (1): 23–36.
Published: 09 January 2019
... antibiotics, out of the cells and provide them with multidrug resistance. Tripartite efflux pumps span both the inner and outer membrane in a similar manner as the T1SS system. They contain an outer membrane channel, a periplasmic adaptor protein and either a resistance-nodulation-cell division (RND...
Biochem Soc Trans (2018) 46 (6): 1485–1494.
Published: 21 November 2018
... to translate some of these findings into inhibitor design and development. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ABC transport proteins electron microscopy molecular modelling multidrug resistance pharmacokinetics transmembrane proteins...
Biochem Soc Trans (2013) 41 (1): 293–298.
Published: 29 January 2013
... of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, and anti-tumour chemotherapeutic treatments are often impaired by innate or acquired MDR (multidrug resistance). Microvesicles released upon chemotherapeutic agents prevent...
Biochem Soc Trans (2005) 33 (5): 1008–1011.
Published: 26 October 2005
... will be discussed in the context of functional and structural similarities that can be observed between primary- and secondary-active multidrug transporters in prokaryotic and eukaryotic cells. The ever-increasing incidence of MDR (multidrug resistance) due to the overexpression of multidrug transporters...
Biochem Soc Trans (2005) 33 (1): 241–245.
Published: 01 February 2005
... in clinical outcome; however, critical studies aimed at proving the hypothesis using Pgp inhibitors in clinical trials have to date failed. Identification of the MRP (multidrug resistance protein)/ABCC subfamily expanded the possible mechanisms of reduced drug accumulation, and the discovery of ABCG2 added...