... of Nature's concept to cope with malfunctions. 1 To whom correspondence should be addressed (email [email protected] ). 31 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 exosome multivesicular body (MVB) protein kinase C (PKC) target...

... Biochemical Society 2010 endocytosis endosome lysosome multivesicular body (MVB) Lysosomes act as the terminal compartment of the endocytic and autophagic pathways ( Figure 1 ). It is now recognized that the delivery of endocytosed and autophagocytosed macromolecules to lysosomes...

... required for transport III (ESCRT-III) vacuolar protein sorting 4 (VPS4) multivesicular body (MVB) ESCRTs (endosomal sorting complexes required for transport) 0, I, II and III, first discovered in Saccharomyces cerevisiae , catalyse receptor sorting at endosomal membranes into vesicles that bud...

... (ESCRT) multivesicular body (MVB) vacuolar protein sorting 4 (Vps4) The endosomal network co-ordinates protein sorting between the Golgi, plasma membrane and lysosome, thereby affecting protein composition within these subcellular compartments. MVBs (multivesicular bodies) are endosomal...

... been shown to cause ALS (amyotrophic lateral sclerosis) [ 30 ]. cancer endosomal sorting complex required for transport (ESCRT) endosome multivesicular body (MVB) neurodegeneration pathogenesis The endocytic down-regulation of numerous signalling receptors such as the EGFR (epidermal...

... correspondence should be addressed (email [email protected] ). 25 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) retrovirus tumour susceptibility gene 101 (Tsg101...

... epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) phosphoinositide 3-kinase (PI3K) protein tyrosine phosphatase 1B (PTP1B) EGF (epidermal growth factor) binding to the EGFR (EGF receptor) promotes increased RTK (receptor...

...) endosome epidermal growth factor receptor (EGFR) His domain phosphotyrosine phosphatase (HD-PTP) multivesicular body (MVB) Down-regulation of mitogenic tyrosine kinase receptors is a process of fundamental importance, since defective receptor down-regulation results in a failure to turn off...

... endosomal sorting complex required for transport (ESCRT) lysosome multivesicular body (MVB) protein sorting Endosomes facilitate transport of membrane proteins between the plasma membrane, the trans -Golgi network and the lysosome/vacuole [ 1 ]. Sorting to the lysosome/vacuole compartment...

... into ILVs and are required for efficient lysosomal degradation of proteins (reviewed in [ 22 ]). autophagy charged multivesicular body protein 2B (CHMP2B) endosomal sorting complex required for transport III (ESCRT-III) endosome frontotemporal dementia (FTD) multivesicular body (MVB) FTD...

... 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 endocytosis endosome lysosome multivesicular body (MVB) MHC class I In mammalian cells, many endocytosed cell-surface proteins, including receptors and bound ligands, are internalized via clathrin-coated pits...

... be addressed (email [email protected] ). 26 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 E3 adaptor endocytosis multivesicular body (MVB) Rsp5p membrane protein trafficking yeast Ubiquitination was initially described as promoting proteasomal...