... to misfolded protein toxicity, but other cell types such as the muscle cells could also be affected. Muscle-restricted expression of the fALS protein mutSOD1 (mutant superoxide dismutase 1) induces muscle atrophy and motoneuron death. We found that several genes have an altered expression in muscles...

...M.J. Rennie The mechanisms of maintenance of the protein mass of muscle and associated connective tissue and bone are becoming more accessible as a result of the use of a combination of well-established techniques for measurement of protein turnover and measurement of protein expression...

...B.G. Nielsen Muscles are responsible for generating the forces required for the movement of multicellular organisms. Microscopically, these forces arise as a consequence of motor proteins (myosin) pulling and sliding along actin filaments. Current knowledge states that the molecular forces between...

... representative of the tissue from which they derive. 1 To whom correspondence should be addressed, at Xcellsyz Ltd (E-mail peter@xcellsyz.com ) 9 4 2002 © 2002 Biochemical Society 2002 adipocytes liver muscle t-antigen Biochemical Society Transactions (2002) Volume 30, part 4...

... of mitochondrial uncoupling through proton-leak reactions. UCP3 is expressed selectively in muscle, a tissue in which it has been estimated that proton leak accounts for approx. 50% of resting energy metabolism. Genetic linkage, association and variant studies suggest a role for UCP3 in obesity and/or diabetes...

... heart liver muscle peroxisome-proliferator-activated receptor α pyruvate dehydrogenase pyruvate dehydrogenase kinase CPT, carnitine palmitoyltransferase FA, fatty acid PDC, pyruvate dehydrogenase complex PDK, pyruvate dehydrogenase kinase PPAR, peroxisome-proliferator-activated receptor...