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Keywords: mutagenesis
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Biochem Soc Trans (2020) 48 (6): 2811–2822.
Published: 16 November 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 DNA polymerases DNA replication and recommbination mutagenesis PCNA proten-protein interaction translesion DNA synthesis DNA replication is one of the most basic cellular processes that ensures...
In Collection
Biochem Soc Trans (2020) 48 (2): 451–462.
Published: 20 March 2020
... replication and recombination DNA synthesis and repair mutagenesis phenotypic heterogeneity single-cell analysis The maintenance of genome integrity is crucial for essential cell functions and accurate transfer of the genetic information across generations. For this reason, all organisms rely...
Biochem Soc Trans (2016) 44 (3): 863–868.
Published: 09 June 2016
... side of the active site to the canopy. The mechanism of hydrogen activation has been dissected by site-directed mutagenesis to identify the catalytic base responsible for splitting molecular hydrogen and possible proton transfer pathways to/from the active site. Previous reported attempts to mutate...
Biochem Soc Trans (2016) 44 (1): 129–142.
Published: 09 February 2016
... development. 1 To whom correspondence should be addressed (email xiichen@ucdavis.edu ). 18 11 2015 © 2016 Authors; published by Portland Press Limited 2016 carbohydrate directed evolution enzymatic synthesis glycosyltransferase mutagenesis protein engineering A growing...
Biochem Soc Trans (2013) 41 (1): 180–184.
Published: 29 January 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 alanine scan family A GPCRs family B GPCRs mutagenesis secretin-like GPCR structure–activity relationship Family B GPCRs have a number of conserved proline residues, including a proline towards the middle of TM helix 6...
Biochem Soc Trans (2012) 40 (6): 1492–1497.
Published: 21 November 2012
... lantibiotic mutagenesis nisin Figure 1 Biosynthesis of nisin ( A ) Formation of rings A and B only (see B ) is shown for clarily. Serine and threonine residues of the unmodified core peptide (with N-terminal leader peptide attached; not shown) are dehydrated by NisB, forming dehydroalanine (DHA...
Biochem Soc Trans (2012) 40 (2): 433–437.
Published: 21 March 2012
... calcitonin mutagenesis receptor activity-modifying protein secretin-like G-protein-coupled receptor structure–activity relationship GPCRs form a number of families. The best characterized of these are the rhodopsin-like or family A GPCRs. The secretin-like or family B GPCRs form receptors...
Biochem Soc Trans (2009) 37 (6): 1343–1346.
Published: 19 November 2009
..., and specific interactions between GABA and some of these residues have been determined. In the present paper, I show how a cation–π interaction for one of the binding site residues has allowed the production of models of GABA docked into the binding site, and these orientations are supported by mutagenesis...
Biochem Soc Trans (2009) 37 (4): 838–842.
Published: 22 July 2009
... both gene-driven (reverse genetics) and phenotype-driven (forward genetics) approaches. A high-efficiency ENU approach results in approx. 25 functional mutations per genome; most of these will result in hypomorphic alleles. Our group has recently begun using ENU mutagenesis as a tool for understanding...
Biochem Soc Trans (2008) 36 (6): 1313–1316.
Published: 19 November 2008
... perturbations. Random mutagenesis was induced, and individual mutagenized chromosomes were recovered by classic crossing schemes involving phenotypical markers and balancer chromosomes. In wild-type larvae, ferritin is predominantly localized in the brain, in regions of the intestine, in wreath cells...
Biochem Soc Trans (2007) 35 (5): 1334–1337.
Published: 25 October 2007
... mutagenesis translesion synthesis ubiquitin The stability of our genetic material is endangered both by DNA-damaging agents from the environment and by endogenous problems during DNA replication arising from spontaneous damage [ 1 ]. DNA repair pathways, the cell's first line of defence against many...
Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... for secretin binding based on receptor mutagenesis and photoaffinity labelling studies. Full agonist analogues of secretin incorporating a photolabile moiety at various positions throughout the pharmacophore covalently label residues within this region, while only N-terminal probes have labelled the core...
Biochem Soc Trans (2005) 33 (5): 1206–1209.
Published: 26 October 2005
... amphotericin B antifungal activity mutagenesis nystatin sterol yeast After more than 40 years of use in antifungal therapy, polyene macrolides nystatin and amphotericin B ( Figure 1 ) still represent the first line treatment of severe systemic fungal infections and several topical mycoses...
Biochem Soc Trans (2004) 32 (6): 1037–1039.
Published: 26 October 2004
... cAMP regulatory element (CRE)-luciferase glucagon G-protein-coupled receptor (GPCR) mutagenesis receptor activation ternary complex The extended ternary complex model for GPCR (G-protein-coupled receptor) activation suggests that they interchange between inactive (R) and active (R*) states...
Biochem Soc Trans (2003) 31 (5): 1042–1046.
Published: 01 October 2003
... in 2D and 3D, a Biochemical Society Focused Meeting held at University of Nottingham, 19–20 June 2003 20 June 2003 © 2003 Biochemical Society 2003 fluorescence spectroscopy mutagenesis secondary-structure prediction steroid receptor transactivation Abbreviations used...