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Biochem Soc Trans (2021) BST20210048.
Published: 08 June 2021
... epigenetic processes (e.g. epithelial–mesenchymal transition) underlying the establishment of micro-metastases and secondary tumors. Interestingly, analyses of sequencing data from untreated metastases inferred depletion of putative driver mutations among metastases, in line with the pivotal role played by...
Biochem Soc Trans (2018) 46 (5): 1325–1332.
Published: 04 October 2018
...Stephanie P. Mo; Judy M. Coulson; Ian A. Prior RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent...
Biochem Soc Trans (2006) 34 (5): 735–737.
Published: 25 October 2006
... disease mechanism in this skeletal disorder, but also the critical determinants of ubiquitin recognition by an ubiquitin-binding protein. The 11 separate PDB mutations identified to date all affect the C-terminal region of p62 containing the UBA domain (ubiquitin-associated domain), a ubiquitin-binding...
B. Zhang, S. Ye, A.A. Sayer, S.R. Hammans, S. Adio, L.J. Hinks, P.J. Smythe, D. Groot, C. Cooper, I.N.M. Day
Biochem Soc Trans (2003) 31 (2): 444–446.
Published: 01 April 2003
...B. Zhang; S. Ye; A.A. Sayer; S.R. Hammans; S. Adio; L.J. Hinks; P.J. Smythe; D. Groot; C. Cooper; I.N.M. Day Somatic mutation in the mitochondrial genome occurs much more rapidly than in the nuclear genome and is a feature, possibly contributory, of the aging of cells and tissues. Identifying...
Biochem Soc Trans (2003) 31 (1): 252–256.
Published: 01 February 2003
...M.P. Carty; M. Glynn; M. Maher; T. Smith; J. Yao; K. Dixon; J. McCann; L. Rynn; A. Flanagan The human skin cancer-prone disease xeroderma pigmentosum variant (XPV) results from a mutation in RAD30 , which encodes the novel lesion bypass DNA polymerase η. XPV cells are characterized by delayed...