...Amanda M. Koenig; Bo Liu; Jianping Hu Plant organelles predominantly rely on the actin cytoskeleton and the myosin motors for long-distance trafficking, while using microtubules and the kinesin motors mostly for short-range movement. The distribution and motility of organelles in the plant cell...

...Isabel W. Shahid-Fuente; Christopher P. Toseland The importance of myosin motor protein is well-characterised within the cytoplasm and cytoskeleton. However, mounting evidence on four nuclear myosins highlights the central role these proteins have in maintaining genomic stability and gene...

...Michelle Peckham The human genome contains 39 genes that encode myosin heavy chains, classified on the basis of their sequence similarity into 12 classes. Most cells express at least 12 different genes, from at least 8 different classes, which are typically composed of several class 1 genes...

...James A. Spudich No matter how many times one explores the structure of the myosin molecule, there is always something new to discover. Here, I describe the myosin mesa, a structural feature of the motor domain that has the characteristics of a binding domain for another protein, possibly myosin...

...Matthew Batchelor; Marcin Wolny; Lorna Dougan; Emanuele Paci; Peter J. Knight; Michelle Peckham The human genome contains 39 myosin genes, divided up into 12 different classes. The structure, cellular function and biochemical properties of many of these isoforms remain poorly characterized...

...) the ‘docking’ of these vesicles/granules at the membrane itself, (iii) the ‘priming’ of the secretory vesicles/granules for the fusion process, and, finally, (iv) the ‘fusion’ of vesicular/granular membranes with the PM to permit content release from the cell. Recent work indicates that non-muscle myosin II...

[email protected] ). 5 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 bidirectional intracellular transport cargo transport dynein kinesin microtubule cytoskeleton myosin Molecular motors belonging to the kinesin, dynein and myosin families are responsible...

...Martin Bähler; Kerstin Elfrink; Peter J. Hanley; Sabine Thelen; Yan Xu Mammals contain two class IX myosins, Myo9a and Myo9b. They are actin-based motorized signalling molecules that negatively regulate RhoA signalling. Myo9a has been implicated in the regulation of epithelial cell morphology...

...Aibing Wang; Xuefei Ma; Mary Anne Conti; Robert S. Adelstein We propose that the in vivo functions of NM II (non-muscle myosin II) can be divided between those that depend on the N-terminal globular motor domain and those less dependent on motor activity but more dependent on the C-terminal domain...

...Verl B. Siththanandan; James R. Sellers The myosin superfamily is diverse in its structure, kinetic mechanisms and cellular function. The enzymatic activities of most myosins are regulated by some means such as Ca 2+ ion binding, phosphorylation or binding of other proteins. In the present review...

...Michelle Peckham Cytoskeletal motors include myosins, kinesins and dyneins. Myosins move along tracks of actin filaments, whereas kinesins and dyneins move along microtubules. Many of these motors are involved in trafficking cargo in cells. However, myosins are mostly monomeric, whereas kinesins...

... Society 2010 myosin β-oxidation peroxin photorespiration protein import receptor The development of in vivo imaging techniques has led to a growing appreciation that organelles are extremely dynamic, often pleomorphic, and motile structures (see Supplementary Movie S1 at http...

...Imogen A. Sparkes Organelle movement in plants cells is extremely dynamic. Movement is driven by the acto-myosin system. Higher plant myosins fall into two classes: classes XI and VIII. Localization studies have highlighted that myosins are present throughout the cytosol, label motile puncta...

... with fluorescent proteins to establish the temporal and spatial pathway for the assembly and constriction of the contractile ring. We combined biochemical analysis of purified proteins (myosin-II, profilin, formin Cdc12p and cofilin), observations of fluorescent fusion proteins in live cells and mathematical...

...I. Lister; R. Roberts; S. Schmitz; M. Walker; J. Trinick; C. Veigel; F. Buss; J. Kendrick-Jones Myosin VI moves towards the minus end of actin filaments unlike all the other myosins so far studied, suggesting that it has unique properties and functions. Myosin VI is present in clathrin-coated pits...