...Jemma L. Trick; Prafulla Aryal; Stephen J. Tucker; Mark S. P. Sansom Gating in channels and nanopores plays a key role in regulating flow of ions across membranes. Molecular simulations provide a ‘computational microscope’ which enables us to examine the physical nature of gating mechanisms...

... in 1976 using the patch-clamp technique [Neher and Sakmann (1976) Nature 260 , 799–802]. Since the 1990s, this work has inspired the use of protein or solid-state nanopores as inexpensive and ultrafast sensors for the detection of biomolecules, including DNA, RNA and proteins, but with particular focus...