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Keywords: neurodegeneration
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Articles
Biochem Soc Trans (2023) 51 (2): 571–577.
Published: 09 March 2023
... neurodegenerative diseases, which implicate either enhanced or reduced ER–mitochondria contacts in neurodegeneration. Taken together, the discussed studies highlight the need for further research into the role of triple organelle contacts, as well as into the exact mechanisms of increased and decreased ER...
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Biochem Soc Trans (2023) 51 (1): 147–159.
Published: 11 January 2023
... membrane, compromising its integrity, and affecting the function of receptors. These facts indicate that the interaction between Aβ oligomers and cell membranes may be one of the central molecular level factors responsible for the onset of neurodegeneration. The present review provides a structural...
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Biochem Soc Trans (2022) 50 (5): 1457–1469.
Published: 05 October 2022
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy neurodegeneration organelles protein quality control ubiquitin Valosin-containing protein (VCP, also p97, or Cdc48p in yeast...
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Biochem Soc Trans (2022) 50 (5): 1489–1503.
Published: 16 September 2022
... in which neurodegeneration mainly affects upper and/or lower motor neurons (MNs). Although the involvement of specific MNs, symptoms, age of onset, and progression differ in MNDs, the main pathogenic mechanism common to most MNDs is represented by proteostasis alteration and proteotoxicity...
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Biochem Soc Trans (2022) 50 (2): 799–811.
Published: 28 March 2022
...). Published by Portland Press Limited on behalf of the Biochemical Society 2022 inflammation linear ubiquitination LUBAC LUBAC inhibitors neurodegeneration Ubiquitin is a 76-amino acid protein that is expressed in all eukaryotic cells; it modifies substrate proteins to regulate...
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Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
... ( emily.sontag@marquette.edu ) 14 1 2022 28 2 2022 2 3 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 ageing neurodegeneration protein aggregation proteostasis Protein homeostasis (proteostasis) is the process...
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Biochem Soc Trans (2022) 50 (1): 119–134.
Published: 23 December 2021
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 liquid-liquid phase separation neurodegeneration RAN translation repeat expansion diseases The human genome contains many simple sequence repeats composed of a short repeat unit known as a short tandem...
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Biochem Soc Trans (2021) 49 (6): 2777–2786.
Published: 23 November 2021
... in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. alpha-synuclein electron microcopy neurodegeneration tau protein Many neurodegenerative diseases are characterized by the presence in the brain...
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Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
... group member [ 61 ]. Binding of the correct HSP70 chaperone to mutant SOD1 is, therefore, an important indicator of the fate, and therefore the toxicity, of a mutant SOD1 molecule. amyotrophic lateral sclerosis molecular chaperones neurodegeneration Parkinson's disease pharmacological...
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Biochem Soc Trans (2019) 47 (6): 1651–1660.
Published: 17 December 2019
... such as in brain tumors, following injury and in neurodegenerative disorders and is highly associated with glial reactivity as well as scar formation. As a key modulator of the immune response during neurodegeneration in the CNS, tenascin-C is highlighted in this mini-review. extracellular matrix glial scar...
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Biochem Soc Trans (2019) 47 (3): 827–838.
Published: 13 May 2019
... alpha-synuclein LRRK2 neurodegeneration Parkinson's disease tau Parkinson's disease (PD) is a complex neurodegenerative disorder clinically known for typical motor features that include muscular rigidity, resting tremor, bradykinesia, and postural instability. In addition, a variety of non...
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Biochem Soc Trans (2019) 47 (2): 663–670.
Published: 05 March 2019
... in LRRK2 mutation carriers. Correspondence: Andrew B. West ( Andrew.West@Duke.edu ) 17 11 2018 15 1 2019 31 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarker exosome LRRK2 neurodegeneration...
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Biochem Soc Trans (2018) 46 (5): 1063–1072.
Published: 21 September 2018
..., including cancer and neurodegeneration, are associated with the loss of the Golgi ribbon and the appearance of a dispersed fragmented Golgi. Here, we review the emerging theme of the Golgi as a cell sensor and highlight the relationship between the morphological status of the Golgi in vertebrate cells...
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Biochem Soc Trans (2018) 46 (4): 829–842.
Published: 09 July 2018
... in disease. Recent advances in understanding mitochondrially controlled cell death pathways and elucidating the mitochondrial permeability pore bioarchitecture are beginning to present new avenues to target neurodegeneration. Novel mitochondrial roles of deubiquitinating enzymes are coming to light...
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Biochem Soc Trans (2017) 45 (4): 1025–1033.
Published: 21 July 2017
... aggregation could be related to progressive neuronal death in different forms of neurodegeneration. For long time, the role of misfolded proteins in mitochondrial function was disputable due to lack of evidence of the location of misfolded aggregates in mitochondria. Recent studies demonstrated...
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Biochem Soc Trans (2017) 45 (2): 381–387.
Published: 13 April 2017
.... Correspondence: Shantá D. Hinton ( sdhinton@wm.edu ) 30 11 2016 17 1 2017 20 1 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 MK-STYX neurite outgrowths neurodegeneration phospho-serine–threonine/tyrosine-binding protein...
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Biochem Soc Trans (2017) 45 (1): 163–172.
Published: 15 February 2017
... are known to form aggregates in PD brains harboring LRRK2 mutations, to neurodegeneration in LRRK2 rodent models. We aim to provide a clear and unbiased review of some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. Correspondence: Darren J. Moore ( darren.moore...
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Biochem Soc Trans (2017) 45 (1): 101–112.
Published: 15 February 2017
... protein response (UPR) plays a critical role in neurodegeneration [ 1 – 4 ]. This has focused attention on the UPR signaling pathways that are activated following the accumulation of misfolded proteins in the endoplasmic reticulum (ER) with the notion that pharmacological modulation of these pathways may...
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Biochem Soc Trans (2017) 45 (1): 155–162.
Published: 15 February 2017
...) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy leucine-rich repeat kinase neurodegeneration Parkinson's disease Leucine-rich repeat...
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Biochem Soc Trans (2016) 44 (6): 1625–1634.
Published: 02 December 2016
... for pathogenic RocCOR tandem domain mutations ( Table 1 ). Taken together, these observations are consistent with GTP-bound LRRK2 being pathogenic and raise the possibility of targeting LRRK2 GTP-binding for PD treatment. Intriguingly, a LRRK2 GTP-binding inhibitor has been reported to reduce neurodegeneration...
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Biochem Soc Trans (2016) 44 (2): 659–661.
Published: 11 April 2016
... leads to disease spread between neurons and also that mutations in this one gene can lead to widely different neuronal selectivities and clinical features. ataxia dementia genetics motor neuron disease neurodegeneration parkinsonism Identifying and diagnosing selective vulnerability...
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Biochem Soc Trans (2016) 44 (1): 177–184.
Published: 09 February 2016
... 4 lysosome neurodegeneration PIKfyve Vac14 Fab1–PIKfyve is the sole lipid kinase that synthesizes PI(3,5)P 2 from phosphatidylinositol-3-phosphate (PI(3) P ) [ 6 , 9 , 10 ]. Fab1 was identified in the budding yeast S. cerevisiae [ 11 ] and was shown to function as a vacuolar PI(3) P...
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Biochem Soc Trans (2015) 43 (4): 621–626.
Published: 03 August 2015
.... Imbalance between Nrf2 and NF-κB pathways is associated with a significant number of diseases ranging from neurodegeneration, autoimmune disorders and cancer [ 21 ]. It is well recognized that the Nrf2 and NF-κB pathways must interplay through multiple molecular interactions, the complexity and consequences...
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Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
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Biochem Soc Trans (2015) 43 (4): 559–565.
Published: 03 August 2015
... or therapeutic agents. Recent researches have reported that TSPO ligands might be valuable in the treatment of brain diseases. This review focuses on currently available TSPO ligands, as useful tools for the treatment of neurodegeneration, neuro-inflammation and neurotrauma. 1 To whom correspondence...
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Biochem Soc Trans (2015) 43 (3): 333–337.
Published: 01 June 2015
... extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies...
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Biochem Soc Trans (2015) 43 (2): 292–296.
Published: 07 April 2015
.... Missing pieces in the Parkinson's disease puzzle Nat. Med. 2010 16 653 661 10.1038/nm.2165 20495568 3 Shapira A.H.V. Olanow C.W. Greenamyer J.T. Bezard E. Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives Lancet...
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Biochem Soc Trans (2014) 42 (5): 1291–1301.
Published: 18 September 2014
... the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We consider...
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Biochem Soc Trans (2014) 42 (4): 1075–1079.
Published: 11 August 2014
... NAD neurodegeneration pantothenate kinase (PANK) Figure 2 Schematic representation of diverse roles of CoA in cellular physiology Coenzyme A and Its Derivatives in Cellular Metabolism and Disease: A Biochemical Society Focused Meeting held at Charles Darwin House, London, U.K...
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Biochem Soc Trans (2014) 42 (4): 1025–1032.
Published: 11 August 2014
... Biochemical Society 2014 anti-metabolite coenzyme A (CoA) neurodegeneration pantothenate protein acetylation vanin Anyone who took a first year undergraduate biochemistry course will (hopefully!) recall that coenzyme A (CoA) is a ubiquitous coenzyme which functions as an acyl group carrier...
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Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... that this approach has in providing novel treatments that have protective and even restorative properties that no current drug treatment can offer. 1 email c.holscher@lancaster.ac.uk 8 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 memory neurodegeneration...
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Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
... • ), alkoxyl radicals (RO • ), peroxyradicals (ROO • ), hypochlorous acid (HOCl), nitric oxide (NO • ), peroxynitrite (ONOO − ), nitrogen dioxide ( • NO 2 ) and dinitrogen trioxide (N 2 O 3 ). antioxidant defence astrocyte neurodegeneration neuron neuroprotection oxidative stress ROS...
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Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
...Jaime L. Schneider; Ana Maria Cuervo The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms...
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Biochem Soc Trans (2013) 41 (1): 241–244.
Published: 29 January 2013
... disease Front. Physiol. 2012 3 229 exosome microvesicle neurodegeneration neuron synaptic plasticity The function of the brain relies on the capacity of billions of synapses to transmit patterns of electrical information through neuronal circuits. Reinforcement of circuits...
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Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
...) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with brain aging and the early stages of neurodegenerative disorders, such as Alzheimer's disease [ 1 ]. Neurons...
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Biochem Soc Trans (2012) 40 (5): 1123–1128.
Published: 19 September 2012
... of dopaminergic neurons, and also suggest the intriguing possibility that the requirement of canonical Wnt signalling could be partly due to β-catenin-dependent co-activation of Nurr1-mediated gene expression. genetics of Parkinson's disease leucine-rich repeat kinase 2 (LRRK2) neurodegeneration...
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Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
... will require the identification of common mechanisms of tau neurotoxicity, and pathways that can be modulated to protect against neurodegeneration. Model organisms, such as Caenorhabditis elegans , provide methods for identifying novel genes and pathways that are involved in tau pathology and may be exploited...
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Biochem Soc Trans (2012) 40 (4): 739–745.
Published: 20 July 2012
... [ 7 ]. Drosophila genetic modifier genetic screening Huntington's disease neurodegeneration HD (Huntington's disease) is a fatal neurodegenerative disorder predominantly characterized by the selective loss of medium spiny neurons in the striatum of patients, leading...
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Biochem Soc Trans (2012) 40 (4): 687–692.
Published: 20 July 2012
...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...
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Biochem Soc Trans (2011) 39 (4): 924–932.
Published: 20 July 2011
... detrimental effects. 1 email yhuang@gladstone.ucsf.edu 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration ApoE, a 299-amino-acid...
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Biochem Soc Trans (2011) 39 (3): 819–822.
Published: 20 May 2011
... aging Alzheimer's disease cholesterol lipid raft neurodegeneration plasma membrane Ca 2+ -ATPase (PMCA) AD (Alzheimer's disease) is one of the most common dementias worldwide associated with aging. It is characterized by a progressive loss of cognitive abilities and severe neurodegeneration...
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Biochem Soc Trans (2010) 38 (5): 1179–1188.
Published: 24 September 2010
... -acetylglucosamine) modification is one such glycosylation with considerable medical interest, reflecting its implication in diseases such as Type 2 diabetes and neurodegeneration. In the present paper, we review recent structural and mechanistic studies into the enzymes responsible for this modification...
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Biochem Soc Trans (2010) 38 (4): 973–976.
Published: 26 July 2010
...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer We previously developed a transgenic Caenorhabditis elegans model of human tauopathy disorders by expressing human tau in nematode worm neurons to explore genetic pathways contributing to tau-induced neurodegeneration. This animal model...
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Biochem Soc Trans (2010) 38 (4): 977–980.
Published: 26 July 2010
... of the dentate gyrus. Once neuronal degeneration takes place, intracellular tau is secreted to the extracellular space. The present review discusses the toxicity of this extracellular tau for surrounding neurons. dentate gyrus glycogen synthase kinase 3 (GSK3) microtubule neurodegeneration phosphorylation...