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Articles

TDP-43 in nuclear condensates: where, how, and why

Ruaridh Lang, Rachel E. Hodgson, Tatyana A. Shelkovnikova

Biochem Soc Trans (2024) 52 (4): 1809–1825.

https://doi.org/10.1042/BST20231447

Published: 03 July 2024

... 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Sheffield in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. ALS condensate neurodegeneration nuclear body...

View articletitled, TDP-43 in nuclear condensates: where, how, and why

Articles

The role of Matrin-3 in physiology and its dysregulation in disease

Macy L. Sprunger, Meredith E. Jackrel

Biochem Soc Trans (2024) 52 (3): 961–972.

https://doi.org/10.1042/BST20220585

Published: 30 May 2024

... 5 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 amyotrophic lateral sclerosis biomolecular condensates intrinsically disordered proteins Matrin-3 neurodegeneration RNA-binding proteins Matrin-3 (MATR3...

View articletitled, The role of Matrin-3 in physiology and its dysregulation in disease

Articles

Exploring potential developmental origins of common neurodegenerative disorders

James P. Catlin, Christine E. Schaner Tooley

Biochem Soc Trans (2024) 52 (3): 1035–1044.

https://doi.org/10.1042/BST20230422

Published: 25 April 2024

... neurodegeneration remains highly debated. Here, we discuss known links between embryonic neurogenesis and neurodegenerative disorders (including common signaling pathways), potential compensatory mechanisms that could delay presentation of neurodegenerative disorders, and the types of model systems that could...

View articletitled, Exploring potential developmental origins of common neurodegenerative disorders

Articles

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Elizaveta A. Olkhova, Laura A. Smith, Bethany H. Dennis, Yi Shiau Ng, Fiona E. N. LeBeau, Gráinne S. Gorman

Biochem Soc Trans (2024) 52 (2): 553–565.

https://doi.org/10.1042/BST20230191

Published: 02 April 2024

... of the hippocampal formation [ 36 ]. This rapid PV+ cell loss was in contrast with the neurodegeneration of SST+ neurons, which occurred in the dentate gyrus later during the chronic stage of the epilepsy. These data suggest an early, preferential vulnerability of PV+ neurons to degeneration [ 36 ]. These findings...

View articletitled, Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Articles

CRISPRi: a way to integrate iPSC-derived neuronal models

Sarah N.J. Franks, Rachel Heon-Roberts, Brent J. Ryan

Biochem Soc Trans (2024) 52 (2): 539–551.

https://doi.org/10.1042/BST20230190

Published: 25 March 2024

... and the effects of disease-associated variants remains a vital step in the understanding of neurodegeneration and the development of therapeutics. Disease modelling using patient induced pluripotent stem cells (iPSCs) has enabled the generation of key cell-types associated with disease whilst maintaining...

View articletitled, CRISPRi: a way to integrate iPSC-derived neuronal models

Articles

New discoveries in ER–mitochondria communication

Margret Helene Bülow, Julia Sellin

Biochem Soc Trans (2023) 51 (2): 571–577.

https://doi.org/10.1042/BST20221305

Published: 09 March 2023

... neurodegenerative diseases, which implicate either enhanced or reduced ER–mitochondria contacts in neurodegeneration. Taken together, the discussed studies highlight the need for further research into the role of triple organelle contacts, as well as into the exact mechanisms of increased and decreased ER...

View articletitled, New discoveries in ER–mitochondria communication

Articles

Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Safak Er, Mikko Airavaara

Biochem Soc Trans (2023) 51 (1): 245–257.

https://doi.org/10.1042/BST20220770

Published: 16 February 2023

...Safak Er; Mikko Airavaara Synucleinopathies constitute a disease family named after alpha-synuclein protein, which is a significant component of the intracellular inclusions called Lewy bodies. Accompanying the progressive neurodegeneration, Lewy bodies and neurites are the main histopathologies...

View articletitled, Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Articles

The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration

Rima Budvytyte, Gintaras Valincius

Biochem Soc Trans (2023) 51 (1): 147–159.

https://doi.org/10.1042/BST20220434

Published: 11 January 2023

... membrane, compromising its integrity, and affecting the function of receptors. These facts indicate that the interaction between Aβ oligomers and cell membranes may be one of the central molecular level factors responsible for the onset of neurodegeneration. The present review provides a structural...

View articletitled, The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration

Articles

The functional importance of VCP to maintaining cellular protein homeostasis

Brittany A. Ahlstedt, Rakesh Ganji, Malavika Raman

Biochem Soc Trans (2022) 50 (5): 1457–1469.

https://doi.org/10.1042/BST20220648

Published: 05 October 2022

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy neurodegeneration organelles protein quality control ubiquitin Valosin-containing protein (VCP, also p97, or Cdc48p in yeast...

View articletitled, The functional importance of VCP to maintaining cellular protein homeostasis

Articles

The role of autophagy-lysosomal pathway in motor neuron diseases

Barbara Tedesco, Veronica Ferrari, Marta Cozzi, Marta Chierichetti, Elena Casarotto, Paola Pramaggiore, Francesco Mina, Margherita Piccolella, Riccardo Cristofani, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Angelo Poletti

Biochem Soc Trans (2022) 50 (5): 1489–1503.

https://doi.org/10.1042/BST20220778

Published: 16 September 2022

... in which neurodegeneration mainly affects upper and/or lower motor neurons (MNs). Although the involvement of specific MNs, symptoms, age of onset, and progression differ in MNDs, the main pathogenic mechanism common to most MNDs is represented by proteostasis alteration and proteotoxicity...

View articletitled, The role of autophagy-lysosomal pathway in motor neuron diseases

Articles

Linear ubiquitination in immune and neurodegenerative diseases, and beyond

In Collection

Cell death and survival

Fuminori Tokunaga, Fumiyo Ikeda

Biochem Soc Trans (2022) 50 (2): 799–811.

https://doi.org/10.1042/BST20211078

Published: 28 March 2022

... LUBAC inhibitors neurodegeneration Substrates can be modified by different ubiquitin moieties at diverse sites, and the modified substrate is decoded by distinct proteins with ubiquitin recognition domains. At least ∼10 000 ubiquitination sites have been identified in human cells [ 8...

View articletitled, Linear ubiquitination in immune and neurodegenerative diseases, and beyond

Articles

Spatial sequestration of misfolded proteins in neurodegenerative diseases

Sarah Rolli, Emily Mitchell Sontag

Biochem Soc Trans (2022) 50 (2): 759–771.

https://doi.org/10.1042/BST20210862

Published: 21 March 2022

... of disease-associated proteins ( Figure 2 ). ageing neurodegeneration protein aggregation proteostasis Table 1. Disease-associated proteins and their aggregation and sequestration patterns Protein Name Disease Aggregate Structure Aggregate Subcellular Localization PQC...

View articletitled, Spatial sequestration of misfolded proteins in neurodegenerative diseases

Articles

The molecular pathogenesis of repeat expansion diseases

Yuzo Fujino, Yoshitaka Nagai

Biochem Soc Trans (2022) 50 (1): 119–134.

https://doi.org/10.1042/BST20200143

Published: 23 December 2021

...-liquid phase separation state caused by these repeat RNAs and repeat polypeptides, as well as potential therapeutic approaches against repeat expansion diseases. liquid-liquid phase separation neurodegeneration RAN translation repeat expansion diseases The human genome contains many simple...

View articletitled, The molecular pathogenesis of repeat expansion diseases

Articles

Insights into neurodegeneration from electron microscopy studies

R. Anthony Crowther

Biochem Soc Trans (2021) 49 (6): 2777–2786.

https://doi.org/10.1042/BST20210719

Published: 23 November 2021

... and the Biochemical Society under a transformative agreement with JISC. alpha-synuclein electron microcopy neurodegeneration tau protein Many neurodegenerative diseases are characterized by the presence in the brain of abnormal fibrous deposits. Two of the most common conditions are Alzheimer's...

View articletitled, Insights into neurodegeneration from electron microscopy studies

Articles

Molecular and pharmacological chaperones for SOD1

Gareth S.A. Wright

Biochem Soc Trans (2020) 48 (4): 1795–1806.

https://doi.org/10.1042/BST20200318

Published: 14 August 2020

... group member [ 61 ]. Binding of the correct HSP70 chaperone to mutant SOD1 is, therefore, an important indicator of the fate, and therefore the toxicity, of a mutant SOD1 molecule. amyotrophic lateral sclerosis molecular chaperones neurodegeneration Parkinson's disease pharmacological...

View articletitled, Molecular and pharmacological chaperones for SOD1

Articles

Immunomodulatory role of the extracellular matrix protein tenascin-C in neuroinflammation

Susanne Wiemann, Jacqueline Reinhard, Andreas Faissner

Biochem Soc Trans (2019) 47 (6): 1651–1660.

https://doi.org/10.1042/BST20190081

Published: 17 December 2019

... such as in brain tumors, following injury and in neurodegenerative disorders and is highly associated with glial reactivity as well as scar formation. As a key modulator of the immune response during neurodegeneration in the CNS, tenascin-C is highlighted in this mini-review. Correspondence: Andreas Faissner...

View articletitled, Immunomodulatory role of the extracellular matrix protein tenascin-C in neuroinflammation

Articles

LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

Tiago Fleming Outeiro, Kirsten Harvey, Antonio Dominguez-Meijide, Ellen Gerhardt

Biochem Soc Trans (2019) 47 (3): 827–838.

https://doi.org/10.1042/BST20180466

Published: 13 May 2019

... alpha-synuclein LRRK2 neurodegeneration Parkinson's disease tau Parkinson's disease (PD) is a complex neurodegenerative disorder clinically known for typical motor features that include muscular rigidity, resting tremor, bradykinesia, and postural instability. In addition, a variety of non...

View articletitled, LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

Articles

Caught in the act: LRRK2 in exosomes

Shijie Wang, Andrew B. West

Biochem Soc Trans (2019) 47 (2): 663–670.

https://doi.org/10.1042/BST20180467

Published: 05 March 2019

... LRRK2-associated phosphorylation events predict disease risk. biomarker exosome LRRK2 neurodegeneration Parkinson disease Genome-wide association studies have identified variants in or nearby the leucine-rich repeat kinase 2 (LRRK2) gene in Parkinson's disease (PD) [ 1 ]. In unbiased...

View articletitled, Caught in the act: LRRK2 in exosomes

Articles

The Golgi architecture and cell sensing

Christian Makhoul, Prajakta Gosavi, Paul A. Gleeson

Biochem Soc Trans (2018) 46 (5): 1063–1072.

https://doi.org/10.1042/BST20180323

Published: 21 September 2018

..., including cancer and neurodegeneration, are associated with the loss of the Golgi ribbon and the appearance of a dispersed fragmented Golgi. Here, we review the emerging theme of the Golgi as a cell sensor and highlight the relationship between the morphological status of the Golgi in vertebrate cells...

View articletitled, The Golgi architecture and cell sensing

Articles

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

Thomas Briston, Amy R. Hicks

Biochem Soc Trans (2018) 46 (4): 829–842.

https://doi.org/10.1042/BST20180025

Published: 09 July 2018

... in disease. Recent advances in understanding mitochondrially controlled cell death pathways and elucidating the mitochondrial permeability pore bioarchitecture are beginning to present new avenues to target neurodegeneration. Novel mitochondrial roles of deubiquitinating enzymes are coming to light...

View articletitled, Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

Articles

Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

Scott W. Burnside, Giles E. Hardingham

Biochem Soc Trans (2017) 45 (6): 1295–1303.

https://doi.org/10.1042/BST20170013

Published: 17 November 2017

... the Creative Commons Attribution License 4.0 (CC BY) . antioxidants neurodegeneration oxidative stress transcription factors Reactive oxygen species (ROS) are oxygen-containing molecules which are primarily formed as a result of incomplete oxygen reduction [ 1 – 3 ]. These substances can...

View articletitled, Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

Articles

Interaction of misfolded proteins and mitochondria in neurodegenerative disorders

Andrey Y. Abramov, Alexey V. Berezhnov, Evgeniya I. Fedotova, Valery P. Zinchenko, Ludmila P. Dolgacheva

Biochem Soc Trans (2017) 45 (4): 1025–1033.

https://doi.org/10.1042/BST20170024

Published: 21 July 2017

... by which misfolded proteins affect mitochondrial function and ROS production and how mitochondrial dysfunction and protein aggregation could be related to progressive neuronal death in different forms of neurodegeneration. For long time, the role of misfolded proteins in mitochondrial function...

View articletitled, Interaction of misfolded proteins and mitochondria in neurodegenerative disorders

Articles

Antagonistic roles for STYX pseudophosphatases in neurite outgrowth

Arya Dahal, Shantá D. Hinton

Biochem Soc Trans (2017) 45 (2): 381–387.

https://doi.org/10.1042/BST20160273

Published: 13 April 2017

... secretory trafficking and cell migration via interaction with p115 . Mol. Biol. Cell 26 , 2263 – 2278 doi: 10.1091/mbc.E15-03-0178 26 Alvarez-Miranda , E.A. , Sinnl , M. and Farhan , H. ( 2015 ) Alteration of Golgi structure by stress: a link to neurodegeneration? Front...

View articletitled, Antagonistic roles for STYX pseudophosphatases in neurite outgrowth

Articles

Translating protein phosphatase research into treatments for neurodegenerative diseases

Jeyapriya R. Sundaram, Irene C.J. Lee, Shirish Shenolikar

Biochem Soc Trans (2017) 45 (1): 101–112.

https://doi.org/10.1042/BST20160157

Published: 15 February 2017

... contributes to aging. Conversely, studies using genetically tractable model organisms argue that adaptation to environmental stress or resistance to proteotoxicity can extend lifespan [ 7 ]. neurodegeneration protein phosphatases therapeutics translation factors unfolded protein response ©...

View articletitled, Translating protein phosphatase research into treatments for neurodegenerative diseases

Articles

The LRRK2–macroautophagy axis and its relevance to Parkinson's disease

Claudia Manzoni

Biochem Soc Trans (2017) 45 (1): 155–162.

https://doi.org/10.1042/BST20160265

Published: 15 February 2017

...) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy leucine-rich repeat kinase neurodegeneration Parkinson's disease Leucine-rich repeat...

View articletitled, The LRRK2–macroautophagy axis and its relevance to Parkinson's disease

Articles

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation

Md. Shariful Islam, Darren J. Moore

Biochem Soc Trans (2017) 45 (1): 163–172.

https://doi.org/10.1042/BST20160264

Published: 15 February 2017

... are known to form aggregates in PD brains harboring LRRK2 mutations, to neurodegeneration in LRRK2 rodent models. We aim to provide a clear and unbiased review of some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. Correspondence: Darren J. Moore ( darren.moore...

View articletitled, Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation

Articles

L'RRK de Triomphe: a solution for LRRK2 GTPase activity?

Jonathon Nixon-Abell, Daniel C. Berwick, Kirsten Harvey

Biochem Soc Trans (2016) 44 (6): 1625–1634.

https://doi.org/10.1042/BST20160240

Published: 02 December 2016

... tandem domain mutations ( Table 1 ). Taken together, these observations are consistent with GTP-bound LRRK2 being pathogenic and raise the possibility of targeting LRRK2 GTP-binding for PD treatment. Intriguingly, a LRRK2 GTP-binding inhibitor has been reported to reduce neurodegeneration in mouse models...

View articletitled, L'RRK de Triomphe: a solution for LRRK2 GTPase activity?

Articles

Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases

John Hardy

Biochem Soc Trans (2016) 44 (2): 659–661.

https://doi.org/10.1042/BST20150287

Published: 11 April 2016

....2014.08.020 25203713 6 Schapira A.H. Complex I: inhibitors, inhibition and neurodegeneration Exp. Neurol. 2010 224 331 335 10.1016/j.expneurol.2010.03.028 20362572 7 Cannon J.R. Tapias V. Na H.M. Honick A.S. Drolet R.E. Greenamyre J.T. A highly...

View articletitled, Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases

Articles

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

Natsuko Jin, Michael J. Lang, Lois S. Weisman

Biochem Soc Trans (2016) 44 (1): 177–184.

https://doi.org/10.1042/BST20150174

Published: 09 February 2016

... affinity [ 31 ]. WIPI-2 has not been tested thus far due to instability. Despite the similarities between Atg18 and WIPI-1,2,3 and 4, it is not clear whether WIPI proteins regulate PI(3,5) P 2 levels in mammalian cells. Fab1 Fig 4 lysosome neurodegeneration PIKfyve Vac14 Phosphorylated...

View articletitled, Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

Articles

Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection

Eleonora Da Pozzo, Chiara Giacomelli, Elisabetta Barresi, Barbara Costa, Sabrina Taliani, Federico Da Settimo Passetti, Claudia Martini

Biochem Soc Trans (2015) 43 (4): 559–565.

https://doi.org/10.1042/BST20150028

Published: 03 August 2015

... or therapeutic agents. Recent researches have reported that TSPO ligands might be valuable in the treatment of brain diseases. This review focuses on currently available TSPO ligands, as useful tools for the treatment of neurodegeneration, neuro-inflammation and neurotrauma. 1 To whom correspondence...

View articletitled, Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection

Articles

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

Joanna D. Wardyn, Amy H. Ponsford, Christopher M. Sanderson

Biochem Soc Trans (2015) 43 (4): 621–626.

https://doi.org/10.1042/BST20150014

Published: 03 August 2015

... kinase beta (IKKβ) Kelch-like ECH-associated protein 1 (Keap1) nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear factor-κB (NF-κB) neurodegeneration Figure 2 Common interactions between p65 and Nrf2 Data obtained from BioGRID were filtered to remove those identified only by co...

View articletitled, Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

Articles

Redox-based regulation of neural stem cell function and Nrf2

Lalitha Madhavan

Biochem Soc Trans (2015) 43 (4): 627–631.

https://doi.org/10.1042/BST20150016

Published: 03 August 2015

... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...

View articletitled, Redox-based regulation of neural stem cell function and Nrf2

Articles

Control of translation in the cold: implications for therapeutic hypothermia

John R.P. Knight, Anne E. Willis

Biochem Soc Trans (2015) 43 (3): 333–337.

https://doi.org/10.1042/BST20150052

Published: 01 June 2015

... extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies...

View articletitled, Control of translation in the cold: implications for therapeutic hypothermia

Articles

Linking microtubules to Parkinson's disease: the case of parkin

Graziella Cappelletti, Francesca Casagrande, Alessandra Calogero, Carmelita De Gregorio, Gianni Pezzoli, Daniele Cartelli

Biochem Soc Trans (2015) 43 (2): 292–296.

https://doi.org/10.1042/BST20150007

Published: 07 April 2015

... neurodegeneration in PD or not. Here, we bear in mind such a key question and move from a brief insight into the basis of MT functions in neurons to the evidence that MT dysfunction occurs in experimental parkinsonism and, finally, to the critical discussion on the interplay between parkin and MT system in cellular...

View articletitled, Linking microtubules to Parkinson's disease: the case of parkin

Articles

Glia in the pathogenesis of neurodegenerative diseases

Alexei Verkhratsky, Vladimir Parpura, Marcela Pekna, Milos Pekny, Michael Sofroniew

Biochem Soc Trans (2014) 42 (5): 1291–1301.

https://doi.org/10.1042/BST20140107

Published: 18 September 2014

... the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We consider...

View articletitled, Glia in the pathogenesis of neurodegenerative diseases

Articles

Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes

Paola Venco, Sabrina Dusi, Lorella Valletta, Valeria Tiranti

Biochem Soc Trans (2014) 42 (4): 1069–1074.

https://doi.org/10.1042/BST20140106

Published: 11 August 2014

...Paola Venco; Sabrina Dusi; Lorella Valletta; Valeria Tiranti NBIA (neurodegeneration with brain iron accumulation) comprises a heterogeneous group of neurodegenerative diseases having as a common denominator, iron overload in specific brain areas, mainly basal ganglia and globus pallidus...

View articletitled, Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes

Articles

Coenzyme A, more than ‘just’ a metabolic cofactor

Balaji Srinivasan, Ody C.M. Sibon

Biochem Soc Trans (2014) 42 (4): 1075–1079.

https://doi.org/10.1042/BST20140125

Published: 11 August 2014

...-review summarized the diverse functionality of CoA, apart from its most classically known metabolic role. It is now necessary for the future to understand the complex consequences of impaired CoA de novo biosynthesis in diseases including neurodegeneration. Resolving such a challenge can be aided both...

View articletitled, Coenzyme A, more than ‘just’ a metabolic cofactor

Articles

Coenzyme A and its derivatives: renaissance of a textbook classic

Frederica L. Theodoulou, Ody C.M. Sibon, Suzanne Jackowski, Ivan Gout

Biochem Soc Trans (2014) 42 (4): 1025–1032.

https://doi.org/10.1042/BST20140176

Published: 11 August 2014

[email protected] ). anti-metabolite coenzyme A (CoA) neurodegeneration pantothenate protein acetylation vanin Anyone who took a first year undergraduate biochemistry course will (hopefully!) recall that coenzyme A (CoA) is a ubiquitous coenzyme which functions as an acyl group carrier...

View articletitled, Coenzyme A and its derivatives: renaissance of a textbook classic

Articles

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

Christian Hölscher

Biochem Soc Trans (2014) 42 (2): 593–599.

https://doi.org/10.1042/BST20140016

Published: 20 March 2014

... the Lifespan: Translational Neuroscience from Molecule to Man: An Independent Meeting held at University College Cork, Ireland, 12–13 September 2013. Organized and Edited by Eoin Fleming (University College Cork, Ireland). memory neurodegeneration oxidative stress synaptic plasticity...

View articletitled, Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

Articles

Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling

Daniel García-Ovejero, Ángel Arévalo-Martín, Beatriz Navarro-Galve, Emmanuel Pinteaux, Eduardo Molina-Holgado, Francisco Molina-Holgado

Biochem Soc Trans (2013) 41 (6): 1577–1582.

https://doi.org/10.1042/BST20130198

Published: 20 November 2013

... The Authors Journal compilation © 2013 Biochemical Society 2013 brain cannabinoid system interleukin-1β neural stem cell fate neurodegeneration neurogenesis neuroprotection Although much has been learnt in recent years about the causes of degeneration within the brain, in terms...

View articletitled, Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling

Articles

Insight into a neuron's preferential susceptibility to oxidative stress

Karen F.S. Bell

Biochem Soc Trans (2013) 41 (6): 1541–1545.

https://doi.org/10.1042/BST20130245

Published: 20 November 2013

... astrocytes have on neuronal health under both normal and pathological contexts, and suggest that the classically neurocentric view of neurodegeneration should be expanded to include an assessment of astrocytic health and function, as neuronal demise would undoubtedly be accelerated by astrocytic decline...

View articletitled, Insight into a neuron's preferential susceptibility to oxidative stress

Articles

Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Jaime L. Schneider, Ana Maria Cuervo

Biochem Soc Trans (2013) 41 (6): 1483–1488.

https://doi.org/10.1042/BST20130126

Published: 20 November 2013

...Jaime L. Schneider; Ana Maria Cuervo The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms...

View articletitled, Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Articles

Exosomes as a novel way of interneuronal communication

Mathilde Chivet, Charlotte Javalet, Fiona Hemming, Karin Pernet-Gallay, Karine Laulagnier, Sandrine Fraboulet, Rémy Sadoul

Biochem Soc Trans (2013) 41 (1): 241–244.

https://doi.org/10.1042/BST20120266

Published: 29 January 2013

... (to R.S.)]. exosome microvesicle neurodegeneration neuron synaptic plasticity The function of the brain relies on the capacity of billions of synapses to transmit patterns of electrical information through neuronal circuits. Reinforcement of circuits underlying associations and memory...

View articletitled, Exosomes as a novel way of interneuronal communication

Articles

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

Fei Yin, Tianyi Jiang, Enrique Cadenas

Biochem Soc Trans (2013) 41 (1): 101–105.

https://doi.org/10.1042/BST20120260

Published: 29 January 2013

... Journal compilation © 2013 Biochemical Society 2013 brain aging c-Jun N-terminal kinase (JNK) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with brain...

View articletitled, Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

Articles

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

Daniel C. Berwick, Kirsten Harvey

Biochem Soc Trans (2012) 40 (5): 1123–1128.

https://doi.org/10.1042/BST20120122

Published: 19 September 2012

... genetics of Parkinson's disease leucine-rich repeat kinase 2 (LRRK2) neurodegeneration Parkinson's disease treatment Wnt signalling PD (Parkinson's disease) is the second most prevalent neurodegenerative disease worldwide. Individuals with PD present with typical motor symptoms...

View articletitled, The importance of Wnt signalling for neurodegeneration in Parkinson's disease

Articles

The role of MAPT sequence variation in mechanisms of disease susceptibility

Tara M. Caffrey, Richard Wade-Martins

Biochem Soc Trans (2012) 40 (4): 687–692.

https://doi.org/10.1042/BST20120063

Published: 20 July 2012

...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...

View articletitled, The role of MAPT sequence variation in mechanisms of disease susceptibility

Articles

Potential neuroprotective strategies against tauopathy

Jeanna M. Wheeler, Chris R. Guthrie, Brian C. Kraemer

Biochem Soc Trans (2012) 40 (4): 656–660.

https://doi.org/10.1042/BST20120017

Published: 20 July 2012

... will require the identification of common mechanisms of tau neurotoxicity, and pathways that can be modulated to protect against neurodegeneration. Model organisms, such as Caenorhabditis elegans , provide methods for identifying novel genes and pathways that are involved in tau pathology and may be exploited...

View articletitled, Potential neuroprotective strategies against tauopathy

Articles

Choosing and using Drosophila models to characterize modifiers of Huntington's disease

Edward W. Green, Flaviano Giorgini

Biochem Soc Trans (2012) 40 (4): 739–745.

https://doi.org/10.1042/BST20120072

Published: 20 July 2012

... and significant time and cost savings between Drosophila and mammalian models makes them an attractive proposition for genetic modifier screening. Drosophila genetic modifier genetic screening Huntington's disease neurodegeneration HD (Huntington's disease) is a fatal neurodegenerative...

View articletitled, Choosing and using Drosophila models to characterize modifiers of Huntington's disease

Articles

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

Clare Davies, Cathy Tournier

Biochem Soc Trans (2012) 40 (1): 85–89.

https://doi.org/10.1042/BST20110641

Published: 19 January 2012

...) mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase kinase 4 (MKK4) mitogen-activated protein kinase kinase 7 (MKK7) neurodegeneration As with other members of the MAPK family, JNK is activated upon dual phosphorylation on a Thr-Pro-Tyr motif located within the activation...

View articletitled, Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

Articles

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

Yadong Huang

Biochem Soc Trans (2011) 39 (4): 924–932.

https://doi.org/10.1042/BST0390924

Published: 20 July 2011

... detrimental effects. 1 email [email protected] 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration ApoE, a 299-amino-acid glycoprotein...

View articletitled, Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

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