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Keyword: neurodegeneration
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Articles
Biochem Soc Trans (2019) 47 (3): 827-838.
Published: 13 May 2019
... Biochemical Society 2019 alpha-synuclein LRRK2 neurodegeneration Parkinson's disease tau Parkinson's disease (PD) is a complex neurodegenerative disorder clinically known for typical motor features that include muscular rigidity, resting tremor, bradykinesia, and postural instability. In...
Articles
Biochem Soc Trans (2019) 47 (2): 663-670.
Published: 05 March 2019
... 2019 31 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarker exosome LRRK2 neurodegeneration Parkinson disease Genome-wide association studies have identified variants in or nearby the leucine-rich repeat...
Articles
Biochem Soc Trans (2018) 46 (5): 1063-1072.
Published: 21 September 2018
..., including cancer and neurodegeneration, are associated with the loss of the Golgi ribbon and the appearance of a dispersed fragmented Golgi. Here, we review the emerging theme of the Golgi as a cell sensor and highlight the relationship between the morphological status of the Golgi in vertebrate cells and...
Articles
Biochem Soc Trans (2018) 46 (4): 829-842.
Published: 09 July 2018
... disease. Recent advances in understanding mitochondrially controlled cell death pathways and elucidating the mitochondrial permeability pore bioarchitecture are beginning to present new avenues to target neurodegeneration. Novel mitochondrial roles of deubiquitinating enzymes are coming to light and...
Articles
Biochem Soc Trans (2017) 45 (6): 1295-1303.
Published: 17 November 2017
... Creative Commons Attribution License 4.0 (CC BY) . antioxidants neurodegeneration oxidative stress transcription factors Reactive oxygen species (ROS) are oxygen-containing molecules which are primarily formed as a result of incomplete oxygen reduction [ 1 – 3 ]. These substances can be...
Articles
Biochem Soc Trans (2017) 45 (4): 1025-1033.
Published: 21 July 2017
... Limited on behalf of the Biochemical Society 2017 α-synuclein β-amyloid mitochondria neurodegeneration ROS tau proteins Ageing of the population in the majority of countries leads to increase in the number of people with age-related disorders, including neurodegenerative diseases...
Articles
Biochem Soc Trans (2017) 45 (2): 381-387.
Published: 13 April 2017
... neurodegenerative disorders and diseases. Correspondence: Shantá D. Hinton ( sdhinton@wm.edu ) 30 11 2016 17 1 2017 20 1 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 MK-STYX neurite outgrowths neurodegeneration phospho...
Articles
Biochem Soc Trans (2017) 45 (1): 163-172.
Published: 15 February 2017
...-proteins, which are known to form aggregates in PD brains harboring LRRK2 mutations, to neurodegeneration in LRRK2 rodent models. We aim to provide a clear and unbiased review of some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. Correspondence: Darren J. Moore...
Articles
Biochem Soc Trans (2017) 45 (1): 101-112.
Published: 15 February 2017
... Biochemical Society 2017 neurodegeneration protein phosphatases therapeutics translation factors unfolded protein response With the greater access to healthcare, many countries have seen sharp increases in the lifespan of their populations. This in turn has contributed to a rising global...
Articles
Biochem Soc Trans (2017) 45 (1): 155-162.
Published: 15 February 2017
...) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy leucine-rich repeat kinase neurodegeneration Parkinson's disease Leucine-rich repeat...
Articles
Biochem Soc Trans (2016) 44 (6): 1625-1634.
Published: 02 December 2016
... ) 12 8 2016 15 9 2016 23 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 GTPases leucine-rich repeat kinase neurodegeneration Parkinson's disease Wnt proteins Parkinson's disease (PD) is the second most...
Articles
Biochem Soc Trans (2016) 44 (2): 659-661.
Published: 11 April 2016
... genetics motor neuron disease neurodegeneration parkinsonism Identifying and diagnosing selective vulnerability is the essence of neurological practice: the practice of ascertaining neurological symptoms is largely the elucidation of lesion location. Yet it is largely mysterious why diseases...
Articles
Biochem Soc Trans (2016) 44 (1): 177-184.
Published: 09 February 2016
... Fig 4 lysosome neurodegeneration PIKfyve Vac14 Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. They regulate multiple pathways, including organization of the cytoskeleton, cellular motility, endocytosis and provide spatial and...
Articles
Biochem Soc Trans (2015) 43 (4): 559-565.
Published: 03 August 2015
... or therapeutic agents. Recent researches have reported that TSPO ligands might be valuable in the treatment of brain diseases. This review focuses on currently available TSPO ligands, as useful tools for the treatment of neurodegeneration, neuro-inflammation and neurotrauma. 1 To whom...
Articles
Biochem Soc Trans (2015) 43 (4): 621-626.
Published: 03 August 2015
... kinase beta (IKKβ) Kelch-like ECH-associated protein 1 (Keap1) nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear factor-κB (NF-κB) neurodegeneration Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor controlling many aspects of cell homoeostasis in...
Articles
Biochem Soc Trans (2015) 43 (4): 627-631.
Published: 03 August 2015
... tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Biochem Soc Trans (2015) 43 (3): 333-337.
Published: 01 June 2015
... extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies the...
Articles
Biochem Soc Trans (2015) 43 (2): 292-296.
Published: 07 April 2015
... microtubule-dependent functions neurodegeneration parkin Parkinson's disease The molecular pathways implicated in neurodegenerative disorders are gradually being elucidated and several contributing factors have been identified. To date, aetiopathogenic mechanisms in Parkinson's disease (PD...
Articles
Biochem Soc Trans (2014) 42 (5): 1291-1301.
Published: 18 September 2014
... paper, we review the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We...
Articles
Biochem Soc Trans (2014) 42 (4): 1069-1074.
Published: 11 August 2014
...Paola Venco; Sabrina Dusi; Lorella Valletta; Valeria Tiranti NBIA (neurodegeneration with brain iron accumulation) comprises a heterogeneous group of neurodegenerative diseases having as a common denominator, iron overload in specific brain areas, mainly basal ganglia and globus pallidus. In the...
Articles
Biochem Soc Trans (2014) 42 (4): 1075-1079.
Published: 11 August 2014
... be addressed (email o.c.m.sibon@umcg.nl ). 1 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 coenzyme A (CoA) metabolic cofactor NAD neurodegeneration pantothenate kinase (PANK) CoA (coenzyme A) was first described in 1947, as a coenzyme...
Articles
Biochem Soc Trans (2014) 42 (4): 1025-1032.
Published: 11 August 2014
... compilation © 2014 Biochemical Society 2014 anti-metabolite coenzyme A (CoA) neurodegeneration pantothenate protein acetylation vanin Anyone who took a first year undergraduate biochemistry course will (hopefully!) recall that coenzyme A (CoA) is a ubiquitous coenzyme which functions as an...
Articles
Biochem Soc Trans (2014) 42 (2): 593-599.
Published: 20 March 2014
... neurodegeneration oxidative stress synaptic plasticity The majority of AD (Alzheimer's disease) and PD (Parkinson's disease) cases are ‘sporadic’, which means that there is no clear genetic pathway that causes the onset of the disease. This makes it more difficult to identify which factors trigger the...
Articles
Biochem Soc Trans (2013) 41 (6): 1483-1488.
Published: 20 November 2013
...Jaime L. Schneider; Ana Maria Cuervo The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms, are...
Articles
Biochem Soc Trans (2013) 41 (6): 1577-1582.
Published: 20 November 2013
... Authors Journal compilation © 2013 Biochemical Society 2013 brain cannabinoid system interleukin-1β neural stem cell fate neurodegeneration neurogenesis neuroprotection Although much has been learnt in recent years about the causes of degeneration within the brain, in terms of...
Articles
Biochem Soc Trans (2013) 41 (6): 1541-1545.
Published: 20 November 2013
... © The Authors Journal compilation © 2013 Biochemical Society 2013 antioxidant defence astrocyte neurodegeneration neuron neuroprotection oxidative stress According to the theory of neuronal health, neurons exist in a dynamic spectrum of states, which range from highly resilient and...
Articles
Biochem Soc Trans (2013) 41 (1): 101-105.
Published: 29 January 2013
... Authors Journal compilation © 2013 Biochemical Society 2013 brain aging c-Jun N-terminal kinase (JNK) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with...
Articles
Biochem Soc Trans (2013) 41 (1): 241-244.
Published: 29 January 2013
... (email remy.sadoul@ujf-grenoble.fr ). 18 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 exosome microvesicle neurodegeneration neuron synaptic plasticity The function of the brain relies on the capacity of billions of synapses to transmit...
Articles
Biochem Soc Trans (2012) 40 (5): 1123-1128.
Published: 19 September 2012
... genetics of Parkinson's disease leucine-rich repeat kinase 2 (LRRK2) neurodegeneration Parkinson's disease treatment Wnt signalling PD (Parkinson's disease) is the second most prevalent neurodegenerative disease worldwide. Individuals with PD present with typical motor symptoms, such as...
Articles
Biochem Soc Trans (2012) 40 (4): 656-660.
Published: 20 July 2012
... tauopathies will require the identification of common mechanisms of tau neurotoxicity, and pathways that can be modulated to protect against neurodegeneration. Model organisms, such as Caenorhabditis elegans , provide methods for identifying novel genes and pathways that are involved in tau pathology and may...
Articles
Biochem Soc Trans (2012) 40 (4): 739-745.
Published: 20 July 2012
...@le.ac.uk ). 9 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 Drosophila genetic modifier genetic screening Huntington's disease neurodegeneration HD (Huntington's disease) is a fatal neurodegenerative disorder predominantly characterized by the...
Articles
Biochem Soc Trans (2012) 40 (4): 687-692.
Published: 20 July 2012
...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...
Articles
Biochem Soc Trans (2012) 40 (1): 85-89.
Published: 19 January 2012
... kinase (JNK) mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase kinase 4 (MKK4) mitogen-activated protein kinase kinase 7 (MKK7) neurodegeneration Cells have the ability to communicate with each other and modify their behaviour according to changes in their environment...
Articles
Biochem Soc Trans (2011) 39 (4): 862-867.
Published: 20 July 2011
... chromosome transgenics (BAC transgenics) leucine-rich repeat kinase 2 (LRRK2) microtubule-associated protein tau neurodegeneration Parkinson's disease Traditionally, transgenic mice are generated by the injection of a transgene expression cassette containing the gene of interest, driven by a...
Articles
Biochem Soc Trans (2011) 39 (4): 924-932.
Published: 20 July 2011
... detrimental effects. 1 email yhuang@gladstone.ucsf.edu 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration AD (Alzheimer's disease) causes...
Articles
Biochem Soc Trans (2011) 39 (3): 819-822.
Published: 20 May 2011
... aging Alzheimer's disease cholesterol lipid raft neurodegeneration plasma membrane Ca 2+ -ATPase (PMCA) AD (Alzheimer's disease) is one of the most common dementias worldwide associated with aging. It is characterized by a progressive loss of cognitive abilities and severe neurodegeneration...
Articles
Biochem Soc Trans (2010) 38 (5): 1179-1188.
Published: 24 September 2010
... -acetylglucosamine) modification is one such glycosylation with considerable medical interest, reflecting its implication in diseases such as Type 2 diabetes and neurodegeneration. In the present paper, we review recent structural and mechanistic studies into the enzymes responsible for this modification...
Articles
Biochem Soc Trans (2010) 38 (4): 973-976.
Published: 26 July 2010
...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer We previously developed a transgenic Caenorhabditis elegans model of human tauopathy disorders by expressing human tau in nematode worm neurons to explore genetic pathways contributing to tau-induced neurodegeneration. This animal model...
Articles
Biochem Soc Trans (2010) 38 (4): 977-980.
Published: 26 July 2010
...@cbm.uam.es ). 8 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 dentate gyrus glycogen synthase kinase 3 (GSK3) microtubule neurodegeneration phosphorylation tau Neuronal morphology is determined by its cytoskeleton which is composed of three...
Articles
Biochem Soc Trans (2010) 38 (2): 545-551.
Published: 22 March 2010
... neurodegeneration phosphorylation prion tau Active bi-directional transportation of organelles along the axon between the cell body and the synapse is essential for neuronal signalling and survival [ 1 ]. Synaptic components, and their precursors, are transported anterogradely by kinesin motors moving...
Articles
Biochem Soc Trans (2010) 38 (2): 471-475.
Published: 22 March 2010
... and/or compensatory reaction to counteract the synaptic loss. 1 To whom correspondence should be addressed (email z.siskova@soton.ac.uk ). 27 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 hypertrophy ME7 neurodegeneration prion structural...
Articles
Biochem Soc Trans (2010) 38 (2): 476-481.
Published: 22 March 2010
... emerged implicating molecules canonically involved in the immune system and inflammation accompanying neurodegeneration (e.g. classical complement cascade) as important players in the normal elimination of synapses in the developing nervous system. As a result, a question has emerged as to whether...
Articles
Biochem Soc Trans (2010) 38 (2): 559-563.
Published: 22 March 2010
... ). 7 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 Caenorhabditis elegans cysteine string protein (CSP) genetic screen neurodegeneration RNA interference (RNAi) As human life expectancy continues to increase, a major challenge we face is that of...
Articles
Biochem Soc Trans (2010) 38 (2): 443-444.
Published: 22 March 2010
.... Correspondence may be addressed to any author (email brose@em.mpg.de , voconno@soton.ac.uk or paul.skehel@ed.ac.uk ). 1 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 brain disease neurodegeneration synaptic dysfunction synaptopathy The Synaptopathies...
Articles
Biochem Soc Trans (2010) 38 (2): 482-487.
Published: 22 March 2010
.... 1 To whom correspondence should be addressed (email grm7@le.ac.uk ). 30 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 behaviour neurodegeneration neurophysiology prion protein (PrP) synaptic dysfunction Compromised synaptic function is...
Articles
Biochem Soc Trans (2009) 37 (6): 1147-1160.
Published: 19 November 2009
... 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 calcium signalling neurodegeneration neuroprotection N -methyl- D -aspartate receptor (NMDAR) oxidative stress transcription NMDARs [NMDA ( N -methyl- D -aspartate) receptors] are cation-passing channels...
Articles
Biochem Soc Trans (2009) 37 (6): 1293-1297.
Published: 19 November 2009
... addressed (email C.Abbott@ed.ac.uk ). 30 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 eukaryotic elongation factor 1A1 (eEF1A1) eukaryotic elongation factor 1A2 (eEF1A2) motor neuron disease neurodegeneration translation elongation wasted mouse...
Articles
Biochem Soc Trans (2009) 37 (5): 1027-1031.
Published: 21 September 2009
... Biochemical Society 2009 Charcot–Marie–Tooth disease endocytosis neurite outgrowth neurodegeneration Rab7 Rab protein The CMT disease (Charcot–Marie–Tooth disease) is one of the most common groups of inherited neuropathies that affect peripheral nerves [ 1 ]. Peripheral nerves connect the...
Articles
Biochem Soc Trans (2009) 37 (1): 167-172.
Published: 20 January 2009
... © 2009 Biochemical Society 2009 cancer endosomal sorting complex required for transport (ESCRT) endosome multivesicular body (MVB) neurodegeneration pathogenesis The endocytic down-regulation of numerous signalling receptors such as the EGFR (epidermal growth factor receptor) plays an...
Articles
Biochem Soc Trans (2009) 37 (1): 299-302.
Published: 20 January 2009
... event was attended by academics, postdoctoral and postgraduate researchers, scientists from industry and clinicians. The themes of this year's conference, neurodegeneration, neuroregeneration, pain, glial cell biology and psychopharmacology, were chosen for their reflection of areas of strength in...